Smart nanoparticles for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 3, 2023

Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.

Language: Английский

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Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 13513 - 13553

Published: Sept. 1, 2022

Prodrugs are chemically modified drug molecules that inactive before administration. After administration, they converted in situ to parent drugs and induce the mechanism of action. The development prodrugs has upgraded conventional treatments terms bioavailability, targeting, reduced side effects. Especially cancer therapy, application achieved substantial therapeutic From serendipitous discovery early stage functional design with pertinence nowadays, importance is self-evident. At present, studying stimuli-responsive activation mechanisms, regulating stimuli intensity vivo, designing nanoscale prodrug formulations major strategies promote prodrugs. In this review, we provide an outlook recent cutting-edge studies on nanosystems from these three aspects. We also discuss prospects challenges future such

Language: Английский

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Stimulus-responsive self-assembled prodrugs in cancer therapy

Chemical Science, Journal Year: 2022, Volume and Issue: 13(15), P. 4239 - 4269

Published: Jan. 1, 2022

Small-molecule prodrugs have become the main toolbox to improve unfavorable physicochemical properties of potential therapeutic compounds in contemporary anti-cancer drug development. Many approved small-molecule prodrugs, however, still face key challenges their pharmacokinetic (PK) and pharmacodynamic (PD) properties, thus severely restricting further clinical applications. Self-assembled emerged as they could take advantage benefits both prodrug design nanomedicine, so maximize loading, reduce premature leakage, PK/PD parameters targeting ability. Notably, temporally spatially controlled release drugs at cancerous sites be achieved by encoding various activable linkers that are sensitive chemical or biological stimuli tumor microenvironment (TME). In this review, we comprehensively summarized recent progress made development single/multiple-stimulus-responsive self-assembled for mono- combinatorial therapy. A special focus was placed on conjugation strategies (polymer-drug conjugates, drug-drug

Language: Английский

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Hyaluronic Acid-Based Nanocarriers for Anticancer Drug Delivery

Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2317 - 2317

Published: May 16, 2023

Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl hydroxyl groups. Moreover, HA serves natural ligand for tumor-targeted drug delivery systems, it contains endocytic receptor, CD44, which overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed improve efficiency distinguish between healthy cancerous tissues, resulting reduced residual toxicity off-target accumulation. This article comprehensively reviews fabrication based on context prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles hydrogels) inorganic composite (gold quantum dots, carbon nanotubes silicon dioxide). Additionally, progress achieved design optimization these their effects therapy are discussed. Finally, review provides summary perspectives, lessons learned so far outlook towards further developments this field.

Language: Английский

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A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(16)

Published: Jan. 25, 2023

Abstract Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint blockade (ICB) therapy is widely developed to improve the efficacy cancer immunotherapy. However, current ICD induced based on apoptosis, i.e., often restricted immunogenicity owing inflammatory quenching that occurs early apoptosis. Recently, pyroptosis demonstrated be a more efficient form, pyroptosis. The contents released during can powerfully activate immunogenicity. Herein, first, it lower doses epigenetic drug decitabine increase GSDME expression prostate (PCa) RM‐1 cells and successfully induce an apoptosis‐pyroptosis transition after photodynamic (PDT). Subsequently, microenvironment dual‐responsive nano‐drug equipped PD‐L1 blocking peptide (TSD@LSN‐D) for self‐synergistic poorly PCa model confirm powerful antitumor response evoked by TSD@LSN‐D not only effectively inhibit primary but also form long‐term memory prevent recurrence metastasis. To best authors’ knowledge, this work presents first concept promotes apoptosis–pyroptosis PDT through modulation. Furthermore, combination ICB opens new platform

Language: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

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Revolutionizing Prostate Cancer Therapy: Artificial intelligence – based Nanocarriers for Precision Diagnosis and Treatment

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653

Published: Feb. 1, 2025

Language: Английский

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Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(18)

Published: July 29, 2021

Abstract This article provides a broad spectrum about the nanoprodrug fabrication advances co‐driven by prodrug and nanotechnology development to potentiate cancer treatment. The inherits features of both concept nanomedicine know‐how, attempts solve underexploited challenge in treatment cooperatively. Prodrugs can release bioactive drugs on‐demand at specific sites reduce systemic toxicity, this is done using special properties tumor microenvironment, such as pH value, glutathione concentration, overexpressed enzymes; or exogenous stimulation, light, heat, ultrasound. nanotechnology, manipulating matter within nanoscale, has high relevance certain biological conditions, been widely utilized therapy. Together, marriage strategy which shield side effects parent drug with pinpoint delivery capability conceived highly camouflaged Trojan horse maneuver cancerous threats.

Language: Английский

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Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(4)

Published: June 4, 2022

Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. However, the nanoparticle formulas usually contain multiple components, especially polymeric materials, which result various issues. Herein, we report an indocyanine green (ICG)-driven assembly of paclitaxel prodrugs integrating near-infrared fluorescence imaging tumor-specific chemotherapy. By feat hydrophilic merit ICG, dimer could form more uniformly monodispersed nanoparticles. This two-in-one strategy reinforces complementary advantages, resulting superior behavior, robust colloidal stability, enhanced accumulation as well desirable vivo feedback The experiments validated activation at sites evidenced by intensity, potent growth suppression, reduced systemic toxicity compared commercial Taxol. universality ICG potentiated toward photosensitizers dyes was confirmed. presentation provides deep insight into feasibility constructing clinical-close alternatives for improving antitumor efficacy.

Language: Английский

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Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(4)

Published: Nov. 9, 2022

Abstract Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy surgery, exhibit suboptimal efficacy for malignant tumors owing serious side effects, drug resistance even relapse. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), emerging localized tumor inhibition, which can produce a large amount reactive oxygen species (ROS) or elevate temperature initiate cell death by non‐invasive irradiation. In consideration poor bioavailability phototherapy agents (PTAs), lots delivery systems have been developed enhance targeted delivery. Nevertheless, carriers inevitably bring biosafety concerns on account their metabolism, degradation, accumulation. Of note, carrier‐free nanomedicine attracts great attention clinical translation with synergistic antitumor effect, is characterized high loading, simplified synthetic method good biocompatibility. this review, latest advances nanomedicines summarized, may provide new paradigm future development precision therapy.

Language: Английский

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