Metal–Organic Frameworks for Drug Delivery: A Design Perspective

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(6), P. 7004 - 7020

Published: Feb. 7, 2021

The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to precision tunability, high surface areas, and loading capacities MOFs. Specifically, MOFs are being explored for a wide variety drug delivery applications. Initially, were used small-molecule pharmaceuticals; however, more recent work focused on macromolecular cargos, such as proteins nucleic acids. Here, we review historical application delivery, with specific focus available options designing These include choices MOF structure, synthetic method, loading. Further considerations tuning, modifications, biocompatibility, cellular targeting, uptake. Altogether, this Review aims guide design novel

Language: Английский

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Activity Trends and Mechanisms in Peroxymonosulfate‐Assisted Catalytic Production of Singlet Oxygen over Atomic Metal‐N‐C Catalysts

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(41), P. 22513 - 22521

Published: Aug. 13, 2021

Abstract We synthesized a series of carbon‐supported atomic metal‐N‐C catalysts (M‐SACs: M=Mn, Fe, Co, Ni, Cu) with similar structural and physicochemical properties to uncover their catalytic activity trends mechanisms. The peroxymonosulfate (PMS) are Fe‐SAC>Co‐SAC>Mn‐SAC>Ni‐SAC>Cu‐SAC, Fe‐SAC displays the best single‐site kinetic value (1.65×10 5 min −1 mol ) compared other species. First‐principles calculations indicate that most reasonable reaction pathway for 1 O 2 production is PMS→OH*→O*→ ; M‐SACs exhibit moderate near‐average Gibbs free energies in each step have better activity, which key outstanding performance Fe‐SACs. This study gives atomic‐scale understanding fundamental mechanisms PMS‐assisted reactive oxygen species via M‐SACs, thus providing guidance developing organic pollutant degradation.

Language: Английский

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Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

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Advances in metal–organic framework-based nanozymes and their applications

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 449, P. 214216 - 214216

Published: Sept. 15, 2021

Language: Английский

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Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(9), P. 2676 - 2687

Published: Feb. 15, 2021

Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive with multiple functions remains a challenge. In this study, mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) TA. The TA-Ag exhibited high catalytic induce hydrogel self-setting without external aid. retained abundant phenolic hydroxyl groups and maintained dynamic redox balance phenol-quinone, providing long-term repeatable adhesiveness, similar adhesion mussels. also afforded uniform distribution network, thereby improving its mechanical properties conductivity. Furthermore, endowed antibacterial through synergistic effects reactive oxygen species generated via POD-like reactions intrinsic bactericidal Ag. Owing these advantages, nanozyme-catalyzed could be effectively used as an adhesive, antibacterial, implantable bioelectrode detect bio-signals, wound dressing accelerate regeneration while preventing infection. Therefore, study provides promising approach for fabrication bioelectronics catalysis.

Language: Английский

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Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6824 - 6863

Published: Jan. 1, 2022

This review comprehensively presents the cutting-edge advances of enzyme confinement using different porous organic frameworks.

Language: Английский

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Ultrasensitive Detection of Bacteria Using a 2D MOF Nanozyme-Amplified Electrochemical Detector

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(24), P. 8544 - 8552

Published: June 7, 2021

Bacterial infection is one of the major causes human death worldwide. To prevent bacterial infectious diseases from spreading, it critical importance to develop convenient, ultrasensitive, and cost-efficient methods for bacteria detection. Here, an electrochemical detector a functional two-dimensional (2D) metal–organic framework (MOF) nanozyme was developed sensitive detection pathogenic Staphylococcus aureus. A dual recognition strategy consisting vancomycin anti-S. aureus antibody proposed specifically anchor S. The 2D MOFs with excellent peroxidase-like activity can efficiently catalyze o-phenylenediamine 2,2-diaminoazobenzene, which ideal signal readout monitoring concentration. Under optimal conditions, present bioassay provides wide range 10–7.5 × 107 colony-forming units CFU/mL limit 6 CFU/mL, better than most previous reports. In addition, established sensor selectively accurately identify in presence other bacteria. work new pathway selective presents promising potential realm clinical diagnosis.

Language: Английский

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Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(33)

Published: July 3, 2021

Clinical treatment of pathogenic infection has emerged as a growing challenge in global public health. Such is currently limited to antibiotics, but abuse antibiotics have induced multidrug resistance and high fatality rates anti-infection therapies. Thus, it vital develop alternative bactericidal agents open novel disinfection pathways. Drawing inspiration from elements the human immune system that show great potential for controlling pathogens or regulating cell apoptosis, design biocatalytic nanomaterials (BCNs) provided unrivaled opportunities future antibacterial More significantly, BCNs exhibit various superior properties cells natural enzymes, such higher performance, extraordinary stability against harsh conditions, scalable production. In this review, most recent efforts toward developing BCN-based biomedical applications combating bacterial infections are focused upon. BCNs' mechanisms, classification BCNs, activities can be triggered augmented by energy conversion, eradication biofilms with systematically introduced discussed. The current challenges prospects also summarized. It anticipated review will provide new therapeutic insights into bacteria offer significant designing nanomaterials.

Language: Английский

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Copper-based metal–organic frameworks for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102686 - 102686

Published: April 29, 2022

Language: Английский

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Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(31)

Published: May 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Language: Английский

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