Hollow Cuprous Oxide@Nitrogen‐Doped Carbon Nanocapsules for Cascade Chemodynamic Therapy DOI
Xiangfu Meng, Ke Zhou, Yong Qian

et al.

Small, Journal Year: 2022, Volume and Issue: 18(15)

Published: March 1, 2022

Abstract Cuprous‐based nanozymes have demonstrated great potential for cascade chemodynamic therapy (CDT) due to their higher catalytic efficiency and simple reaction conditions. Here, hollow cuprous oxide@nitrogen‐doped carbon (HCONC) dual‐shell structures are designed as CDT oncotherapy. This HCONC with a size distribution of 130 nm is synthesized by one‐step hydrothermal method using cupric nitrate dimethyl formamide precursors. The thin‐layer (1.88 nm) enhances the water‐stability reduces systemic toxicity oxide nanocrystals. dissolved Cu + in acid solution induces Fenton‐like exhibits fast rate catalyzing H 2 O into highly toxic hydroxyl radicals (·OH). Meanwhile, formed consumes oversaturated glutathione (GSH) avoid its destruction ROS at intracellular level. In general, both cellular animal experiments show that demonstrates excellent antitumor ability without causing significant toxicity, which may present tremendous clinical cancer therapy.

Language: Английский

Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy DOI Creative Commons
Wenyan Wang, Shunyu Yao, Jingjing Luo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 11, 2025

Hypoxic tumors present a significant challenge in cancer therapy due to their ability adaptation low-oxygen environments, which supports tumor survival and resistance treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is crucial mechanism that helps sustain cellular homeostasis hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, co-delivers hydroxychloroquine mitochondria-targeting photosensitizer, designed induce cascaded oxidative stress regulating mitophagy for treatment These nanoparticles are hypoxia-responsive release loaded guest molecules cells. The released disrupts process, thereby increasing further weakening Additionally, upon laser irradiation, photosensitizer generates reactive oxygen species independent oxygen, inducing damage activation. dual action simultaneous spatiotemporal activation flux blockade results enhanced autophagic stress, ultimately driving cell death. Our work highlights effectiveness hydroxychloroquine-mediated combined with mitochondria-targeted cascade-amplified against has been recognized as Here, group fabricates nanoparticle codelivering (HCQ) sulfur-substituted methylated nile blue analog, capable via

Language: Английский

Citations

3
SLC5A3 depletion promotes apoptosis by inducing mitochondrial dysfunction and mitophagy in gemcitabine-resistant pancreatic cancer cells DOI Creative Commons
Minsoo Kim,

Woosol Chris Hong,

Hyeon Woong Kang

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 7, 2025

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis, largely due to the rapid development of chemoresistance in patients. Mitochondrial dynamics play crucial role cell survival. Currently, specific mechanisms underlying gemcitabine resistance PDAC remain unknown. In this study, we identified sodium/myo-inositol co-transporter solute carrier family 5 member 3 (SLC5A3) as key modulator promoting PDAC. SLC5A3 levels were significantly upregulated gemcitabine-resistant cells, enhancing their survival by stabilizing mitochondrial functions and inhibiting apoptosis. analysis showed that inhibition disrupted dynamics, leading increased reactive oxygen species production, fission, impaired oxidative phosphorylation. Moreover, activated PTEN-induced kinase 1/Parkin-mediated mitophagy pathway, resulting excessive removal damaged healthy mitochondria, thereby depleting reserves sensitizing cells vivo studies revealed targeting enhanced efficacy reduced tumor growth. Collectively, these results suggest SLC5A3-mediated regulation promising therapeutic strategy overcome

Language: Английский

Citations

2
A mitochondria-targeted and viscosity-sensitive near-infrared fluorescent probe for visualization of fatty liver, inflammation and photodynamic cancer therapy DOI
Li Fan,

Qi Zan,

Xiaodong Wang

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 449, P. 137762 - 137762

Published: June 23, 2022

Language: Английский

Citations

56
Reversing breast cancer bone metastasis by metal organic framework-capped nanotherapeutics via suppressing osteoclastogenesis DOI
Binhua Zou,

Zushuang Xiong,

Lizhen He

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 285, P. 121549 - 121549

Published: May 3, 2022

Language: Английский

Citations

51
Hollow Cuprous Oxide@Nitrogen‐Doped Carbon Nanocapsules for Cascade Chemodynamic Therapy DOI
Xiangfu Meng, Ke Zhou, Yong Qian

et al.

Small, Journal Year: 2022, Volume and Issue: 18(15)

Published: March 1, 2022

Abstract Cuprous‐based nanozymes have demonstrated great potential for cascade chemodynamic therapy (CDT) due to their higher catalytic efficiency and simple reaction conditions. Here, hollow cuprous oxide@nitrogen‐doped carbon (HCONC) dual‐shell structures are designed as CDT oncotherapy. This HCONC with a size distribution of 130 nm is synthesized by one‐step hydrothermal method using cupric nitrate dimethyl formamide precursors. The thin‐layer (1.88 nm) enhances the water‐stability reduces systemic toxicity oxide nanocrystals. dissolved Cu + in acid solution induces Fenton‐like exhibits fast rate catalyzing H 2 O into highly toxic hydroxyl radicals (·OH). Meanwhile, formed consumes oversaturated glutathione (GSH) avoid its destruction ROS at intracellular level. In general, both cellular animal experiments show that demonstrates excellent antitumor ability without causing significant toxicity, which may present tremendous clinical cancer therapy.

Language: Английский

Citations

50