Research progress on double-network hydrogels

Materials Today Communications, Journal Year: 2021, Volume and Issue: 29, P. 102757 - 102757

Published: Sept. 4, 2021

Language: Английский

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Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Polymers, Journal Year: 2021, Volume and Issue: 13(21), P. 3782 - 3782

Published: Oct. 31, 2021

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of gave rise ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms durability stability due its capacity reform shape, injectability, stretchability thereby regaining back the original property. review focuses on various mechanisms (covalent non-covalent interactions) these hydrogels, methods used evaluate their properties, applications wound healing, drug delivery, cell encapsulation, tissue engineering systems. Furthermore, composite enhance hydrogel’s properties. Hence, findings research with briefly discussed order emphasize healing such hydrogels. Additionally, properties recent advancements towards 3D bioprinting also reviewed. The concluded by proposing several pertinent challenges encountered at present as well some prominent future perspectives.

Language: Английский

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Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(2), P. 351 - 351

Published: Jan. 17, 2022

The search for higher-quality nanomaterials medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled to make significant progress in medical applications. However, limited tissue scaffolding When nanoparticles nanofibers combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery biosensing. To prepare nanofiber nanoparticle hybrids (NNHs), there two primary ways. electrospinning technology was used produce NNHs a single step. An alternate way is use self-assembly technique create fibers. paper describes creation of from routinely biocompatible polymer composites. Single-step procedures methodologies discuss preparation NNHs. It combines recent research discoveries focus on application release, engineering last years.

Language: Английский

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Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 10, 2023

While hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing their inefficient resistance. Herein, acrylated β-cyclodextrin with bile acid is self-assembled into polymerizable pseudorotaxane via precise host-guest recognition, which photopolymerized acrylamide obtain conductive rotaxane (PR-Gel). The topological networks PR-Gel all desirable properties this system due the large conformational freedom mobile junctions, including excellent stretchability along superior based strain sensor can sensitively detect distinguish body motions subtle muscle movements. three-dimensional printing fabricated exhibit high resolution altitude complexity, real-time human electrocardiogram signals detected repeating stability. self-heal air, has highly repeatable adhesion skin, demonstrating its great potential sensors.

Language: Английский

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Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Materials Today Bio, Journal Year: 2022, Volume and Issue: 16, P. 100412 - 100412

Published: Aug. 29, 2022

Due to microbial infections dramatically affect cell survival and increase the risk of implant failure, scaffolds produced with antimicrobial materials are now much more likely be successful. Multidrug-resistant without suitable prevention strategies increasing at an alarming rate. The ability cells organize, develop, differentiate, produce a functioning extracellular matrix (ECM) create new functional tissue can all controlled by careful control microenvironment. This review covers present state advanced develop properties for bone, oral tissue, skin, muscle, nerve, trachea, cardiac other engineering applications. focuses on development against bacteria fungi using wide range materials, including polymers, biopolymers, glass, ceramics antimicrobials agents such as antibiotics, antiseptics, peptides, metals, carbon nanomaterials, combinatorial strategies, includes discussions mechanisms involved in these approaches. toxicological aspects also analyzed ensure future technological transfer clinics. main methods characterizing scaffolds' antibiofilm described. production porous supports, electrospinning, phase separation, gas foaming, porogen method, polymerization solution, fiber mesh coating, self-assembly, membrane lamination, freeze drying, 3D printing bioprinting, among others, included this article. These important advances materials-based regenerative medicine offer many promising avenues material design tissue-engineering communities.

Language: Английский

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Biomimetic peptide dynamic hydrogel inspired by humanized defensin nanonets as the wound-healing gel coating

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 144266 - 144266

Published: June 20, 2023

Clinical treatment of chronic wounds, particularly those prone to relapse, has been hampered by the regeneration, infection complications, and malignant transformation disordered tissue adhesions. At surface intestinal endothelial, human defensins self-assemble into higher-order nanonets that defend host cells, fight inflammation promote wound healing. Inspired this antimicrobial nanostructured network, we herein attempted construct an nanonet with hemostatic function integrated as dressing. Aiding molecular docking dynamics analysis, designed a nanogel called ACFP, which was constructed spontaneously assembling two RADA16-based hydrogelators one θ-defensin-derived peptide motif. As expected, ACFP possesses properties derived from structure defensin, well ability prevent bleeding effectively injectable biocompatible hydrogel, successfully treated epidermal wounds associated multiple bacterial infections, promoted healing complicated intraperitoneal involving cecum adjacent abdominal walls while preventing adhesion. In addition providing comprehensive therapeutic approach tremendous clinical potential for therapy, may encourage development biomimetic hydrogels functions against wide range diseases.

Language: Английский

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A Highly Stretchable, Conductive, and Transparent Bioadhesive Hydrogel as a Flexible Sensor for Enhanced Real‐Time Human Health Monitoring

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 21, 2024

Real-time continuous monitoring of non-cognitive markers is crucial for the early detection and management chronic conditions. Current diagnostic methods are often invasive not suitable at-home monitoring. An elastic, adhesive, biodegradable hydrogel-based wearable sensor with superior accuracy durability real-time human health developed. Employing a supramolecular engineering strategy, pseudo-slide-ring hydrogel synthesized by combining polyacrylamide (pAAm), β-cyclodextrin (β-CD), poly 2-(acryloyloxy)ethyltrimethylammonium chloride (AETAc) bio ionic liquid (Bio-IL). This novel approach decouples conflicting mechano-chemical effects arising from different molecular building blocks provides balance mechanical toughness (1.1 × 10

Language: Английский

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Nano-crosslinked dynamic hydrogels for biomedical applications

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100640 - 100640

Published: April 23, 2023

Hydrogels resemble natural extracellular matrices and have been widely studied for biomedical applications. Nano-crosslinked dynamic hydrogels combine the injectability self-healing property of with versatility nanomaterials exhibit unique advantages. The incorporation as crosslinkers can improve mechanical properties (strength, injectability, shear-thinning properties) by reinforcing skeleton endowing them multifunctionality. functional that respond to external stimuli (such pH, heat, light, electromagnetic stimuli) photothermal properties, antimicrobial stone regeneration abilities, or tissue repair abilities constructed through reversible covalent crosslinking strategies physical strategies. possible cytotoxicity incorporated be reduced. Nanomaterial show excellent biocompatibility facilitate cell proliferation differentiation This review introduces different nano-crosslinked in medical field, from fabrication application. In this review, hydrogel fabrication, such metals metallic oxides, nanoclays, carbon-based nanomaterials, black phosphorus (BP), polymers, liposomes, are discussed. We also introduce method commonly used nanodynamic hydrogels. Finally, applications presented. hope summary will help researchers related research fields quickly understand develop more preparation promote their development

Language: Английский

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Synergistic strengthening of PVA ionic conductive hydrogels using aramid nanofibers and tannic acid for mechanically robust, antifreezing, water-retaining and antibacterial flexible sensors

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 1260 - 1271

Published: Oct. 26, 2023

Language: Английский

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Self-healing hydrogels as injectable implants: Advances in translational wound healing

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790

Published: March 20, 2024

Language: Английский

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