International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126535 - 126535
Published: Aug. 26, 2023
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126535 - 126535
Published: Aug. 26, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
120Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)
Published: Nov. 22, 2023
Abstract Hydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue‐like mechanical properties, superior bio‐compatibility, the ability conduct both electrons and ions, multiple stimuli‐responsiveness. However, hydrogels are vulnerable damage, which limits usage in developing durable hydrogel‐based bioelectronics. Self‐healing aim endow with property repairing specific functions after failure, thus improving durability, reliability, longevity. This review discusses recent advances self‐healing hydrogels, from mechanisms, material chemistry, strategies for properties improvement hydrogel materials, design, fabrication, applications bioelectronics, including wearable physical biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable etc. Furthermore, persisting challenges hampering development prospects proposed. is expected expedite research
Language: Английский
Citations
111Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)
Published: April 13, 2023
Abstract Today, self-healing graphene- and MXene-based composites have attracted researchers due to the increase in durability as well cost reduction long-time applications. Different studies focused on designing novel with enhanced sensitivity, stretchability, flexibility improved electrical conductivity, healing efficacy, mechanical properties, energy conversion efficacy. These properties can be employed field of wearable sensors, supercapacitors, anticorrosive coatings, electromagnetic interference shielding, electronic-skin, soft robotics, etc. However, it appears that more explorations are still needed achieve excellent arbitrary shape adaptability, suitable adhesiveness, ideal durability, high immediate responsibility, outstanding features. Besides, optimizing reaction/synthesis conditions finding strategies for functionalization/modification crucial aspects should comprehensively investigated. MXenes graphene exhibited superior electrochemical abundant surface terminations great area, which important evolve biomedical sensing stretchability criteria need their future Herein, most recent advancements pertaining applications deliberated, focusing challenges perspectives.
Language: Английский
Citations
93Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209
Published: Nov. 15, 2023
Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse
Language: Английский
Citations
74Polymers, Journal Year: 2023, Volume and Issue: 15(9), P. 2000 - 2000
Published: April 23, 2023
One of the most advanced, promising, and commercially viable research issues in world hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition merits ordinary dressings, functional dressings can adjust their chemical/physical properties satisfy different types, carry out corresponding reactions actively create a healing environment conducive repair, also control drug release provide long-lasting benefit. Although lot in-depth has been conducted over last few decades, very studies have properly summarized. order give researchers basic blueprint for designing motivate them develop ever-more we summarized development recent years, as well current situation future trends, light preparation mechanisms effects.
Language: Английский
Citations
45Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: March 8, 2024
Abstract Sustainable agriculture plays a crucial role in meeting the growing global demand for food while minimizing adverse environmental impacts from overuse of synthetic pesticides and conventional fertilizers. In this context, renewable biopolymers being more sustainable offer viable solution to improve agricultural sustainability production. Nano/micro-structural supramolecular are among these innovative that much sought after their unique features. These biomaterials have complex hierarchical structures, great stability, adjustable mechanical strength, stimuli-responsiveness, self-healing attributes. Functional molecules may be added flexible structure, enabling novel uses. This overview scrutinizes how nano/micro-structural radically alter farming practices solve lingering problems sector namely production, soil health, resource efficiency. Controlled bioactive ingredient released allows tailored administration agrochemicals, agents, biostimulators as they enhance nutrient absorption, moisture retention, root growth. protect crops by appending antimicrobials biosensing entities eco-friendliness supports agriculture. Despite potential, further studies warranted understand optimize usage domain. effort seeks bridge knowledge gap investigating applications, challenges, future prospects sector. Through experimental investigations theoretical modeling, aims provide valuable insights into practical implementation optimization agriculture, ultimately contributing development eco-friendly solutions productivity impact.
Language: Английский
Citations
28International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3849 - 3849
Published: March 29, 2024
This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients
Language: Английский
Citations
26Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121973 - 121973
Published: Feb. 22, 2024
Language: Английский
Citations
23Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 342, P. 122389 - 122389
Published: June 13, 2024
The paper reports new hydrogels based on quaternary ammonium salts of chitosan designed as biocidal products. derivative was crosslinked with salicylaldehyde via reversible imine bonds and supramolecular self-assemble to give dynamic which respond environmental stimuli. crosslinking mechanism demonstrated by 1H NMR FTIR spectroscopy, X-ray diffraction polarized light microscopy. hydrogel nature, self-healing thixotropy were proved rheological investigation visual observation, their morphology assessed scanning electron relevant properties for application products, such swelling, dissolution, bioadhesiveness, antimicrobial activity ex-vivo hemocompatibility in vivo local toxicity biocompatibility experimental mice measured analyzed relationship the imination degree influence each component. It found that are superabsorbent, have good adhesivity skin various surfaces against gram-positive gram-negative bacteria, while being hemocompatible biocompatible. Besides, easily biodegraded soil. All these recommend studied ecofriendly agents living tissues surfaces, but also open perspectives use platform applications tissue engineering, wound healing, or drug delivery systems.
Language: Английский
Citations
21International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6610 - 6610
Published: June 15, 2024
Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives
Language: Английский
Citations
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