Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Language: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

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Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12261 - 12275

Published: April 29, 2024

Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed remodeling The Fe-TCPP-MOFs were utilized not only as core catalysis component against destruction but also biocompatible delivery vector of an immunologic agonist, improving long circulation and enrichment. Concurrently, it catalyzes decomposition H2O2 within tumor, yielding oxygen to augment photodynamic therapy. induced ferroptosis, in synergy with therapy, prompts liberation tumor-associated antigens from cells inducing immunogenic cell death. Phototriggered on-demand release R848 agonists stimulated maturation dendritic reverted tumor-promoting M2 phenotypes into adoptive M1 macrophages, which further reshaped Notably, effectively restrains well-established tumors, such B16F10 melanoma. Moreover, demonstrates distal tumor-inhibiting effect upon situ light treatment. What is more, lung metastasis model, elicits robust immune memory, conferring enduring protection rechallenge. Our study presents straightforward broadly applicable strategy crafting nanozymes potential thwart cancer recurrence metastasis.

Language: Английский

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Light‐Triggered Nitric Oxide Nanogenerator with Highl‐Arginine Loading for Synergistic Photodynamic/Gas/Photothermal Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(20)

Published: March 17, 2023

The development of nanomedicines that combine photothermal therapy (PTT) with photodynamic (PDT) is considered promising for cancer treatment, but still faces the challenge enhancing tumoricidal efficiency. Fortunately, apart from well-acknowledged effect on direct tumor cell-killing, nitric oxide (NO) also to be effective enhancement both PTT and PDT. However, low loading efficiency NO precursor short half-life time diffusion distance hamper synergistic therapeutic efficacy NO. Taking aforementioned factors into account, a mitochondria-targeted nanogenerator, EArgFe@Ce6, constructed achieve high donor l-Arginine (l-Arg) photodynamic/gas/photothermal upon single 660 nm light irradiation. coordination epigallocatechin gallate (EGCG) ferric ions (Fe3+ ) provides EArgFe@Ce6 supreme capability perform low-temperature (mPTT). EGCG endows mitochondria-targeting meanwhile favors hypoxia alleviation enhanced PDT-produced massive reactive oxygen species (ROS) further catalyzes l-Arg generate considerable amount gas sensitize mPTT In vitro in vivo studies demonstrate triggered by irradiation highly treatments.

Language: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

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