Prepared MW‐Immunosensitizers Precisely Release NO to Downregulate HIF‐1α Expression and Enhance Immunogenic Cell Death DOI Open Access

Wenna Guo,

Zengzhen Chen,

Qiong Wu

et al.

Small, Journal Year: 2023, Volume and Issue: 20(17)

Published: Dec. 1, 2023

Abstract Microwave thermotherapy (MWTT) has limited its application in the clinic due to high rate of metastasis and recurrence after treatment. Nitric oxide (NO) is a gaseous molecule that can address rates MWTT by increasing thermal sensitivity, down‐regulating expression hypoxia‐inducible factor‐1 (HIF‐1), inducing immunogenic cell death (ICD). Therefore, GaMOF‐Arg designed, gallium‐based organic skeleton material derivative loaded with L‐arginine (L‐Arg), coupled mitochondria‐targeting drug triphenylphosphine (TPP) on surface obtain GaMOF‐Arg‐TPP (GAT) MW‐immunosensitizers. When GAT MW‐immunosensitizers are introduced into mice through tail vein, reactive oxygen species (ROS) generated L‐Arg released under MW action. Then, reacts ROS generate NO, which not only downregulates HIF‐1 improve tumor hypoxia exacerbated MW, but also enhances immune responses augment calreticulin (CRT) exposure, mobility group box 1 (HMGB1) release, T‐cell proliferation achieve prevention recurrence. In addition, NO induce mitochondria damage increase their sensitivity MWTT. This study provides unique insight use metal‐organic framework enhance therapy offers new way treat cancer efficiently.

Language: Английский

A Mild Hyperthermia Hollow Carbon Nanozyme as Pyroptosis Inducer for Boosted Antitumor Immunity DOI
Na Tao, Lei Jiao, Huihuang Li

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22844 - 22858

Published: Nov. 9, 2023

The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive microenvironments. Pyroptosis, a form programmed cell death, can release antigens, activate effective immunogenicity, improve efficiency ICB, but efficient pyroptosis treatment currently limited. Herein, we show mild hyperthermia-enhanced pyroptosis-mediated based on hollow carbon nanozyme, which specifically amplify oxidative stress-triggered synchronously magnify anticancer responses microenvironment. sphere modified with iron copper atoms (HCS-FeCu) enzyme-mimicking activities been engineered to induce via radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both vitro vivo antineoplastic results confirm superiority HCS-FeCu nanozyme-induced pyroptosis. Moreover, photothermal-activated combining anti-PD-1 enhance antitumor immunotherapy. Theoretical calculations further indicate that photothermal stimulation generates high-energy electrons enhances interaction between surface adsorbed oxygen, facilitating molecular activation, improves ROS production efficiency. This work presents an approach effectively transforms immunologically "cold" into "hot" ones, significant implications

Language: Английский

Citations

46
Emerging nitric oxide gas‐assisted cancer photothermal treatment DOI Creative Commons
Shuang Liang, Yufei Liu,

Hongquan Zhu

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

Citations

38
Gas Therapy: Generating, Delivery, and Biomedical Applications DOI
Pejman Ghaffari‐Bohlouli, Hafez Jafari, Oseweuba Valentine Okoro

et al.

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

Citations

18
Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer DOI Creative Commons
Le Tang, Xiao Yang, Liwen He

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

Citations

2
Organic coordination nanoparticles for phototheranostics DOI
He Ren, Jiexin Li, Jonathan F. Lovell

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215634 - 215634

Published: Jan. 3, 2024

Language: Английский

Citations

11
Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT DOI

Xinxin Lu,

Chun Xue,

Jianhui Dong

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3209 - 3225

Published: Jan. 1, 2024

This review summarizes the recent advances of nanoplatform-based strategies to efficiently amplify tumoricidal capability PDT.

Language: Английский

Citations

10
Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect DOI
Huijuan Zheng, Huimin Lin, Hao Tian

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

Citations

9
Tumor-Specific Liquid Metal Nitric Oxide Nanogenerator for Enhanced Breast Cancer Therapy DOI Creative Commons
Su Chen, Jianhan Lin, Cong Li

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 101018 - 101018

Published: Jan. 10, 2025

Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment integrated platforms combination or synergistic therapies. Although a nanoengineering strategy been proposed to overcome deficiencies NO gas small donor molecules, such as short half-life, lipophilicity, non-selectivity, poor stability, it remains challenging prepare nanomedicines with simple composition, multiple functions enhanced therapeutic efficacy. Herein, we build liquid metal nanodroplet (LMND)-based nanogenerator (LMND@HSG) that is stabilized by bioreducible guanylated hyperbranched poly(amido amine) (HSG) ligand. Mechanically, tumor microenvironment specifically triggers cascade process glutathione elimination, reactive oxygen species (ROS) generation, release. According actual demand, ROS concentrations could be readily controlled tuning LMND HSG feed amounts. Along intrinsic anticancer property (ROS-mediated apoptosis anti-angiogenesis), LMND@HSG administration further enhance growth suppression compared alone. From this study, leveraging therapy provides more possibilities prospect LMND-based nanomedicines.

Language: Английский

Citations

1
Multi-Enzyme Cascade-Triggered Nitric Oxide Release Nanoplatform Combined with Chemo Starvation-like Therapy for Multidrug-Resistant Cancers DOI
Ge Li, Xinyue Lu,

Shixin Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(26), P. 31285 - 31299

Published: June 22, 2023

Tumor drug resistance has long been a major challenge in medical oncology. Ferroptosis is form of regulated cell death with promising clinical applications. However, the efficacy ferroptosis-inducing agents often limited by endogenous factors when used alone, and thus, synergistic therapy offers strategy to address this issue. In study, we developed an iron-doped metal-organic framework (MOF), Fe/ZIF-8, loaded glucose oxidase (Gox), l-arginine (l-arg), adriamycin hydrochloride (Dox). The folic acid (FA)-targeted ZIF-8 (GLDFe/Z-FA) prepared was shown be multifunctional nanoparticle based on hydrogen peroxide (H2O2) glucose, which trigger adaptive cellular responses cancer cells. intracellular level adenosine-triphosphate (ATP) content decreased, indicating that GLDFe/Z-FA reduced metabolic rate induced tumor starvation. And generated •OH H2O2 reactive oxygen species (ROS) overload implement chemodynamic (CDT). ROS catalyzed l-arg released from release nitric oxide (NO), inhibited P-glycoprotein expression, prevented Dox efflux, accumulated enhance cytotoxicity. also glutathione degradation, further disrupted redox homeostasis, enhanced CDT, death. It follow ferroptosis pathway strongly proliferation both vitro vivo. These findings demonstrate effectively inhibits proliferation, highlighting its potential as viable therapeutic approach suppress progression.

Language: Английский

Citations

20
FeP‐Based Nanotheranostic Platform for Enhanced Phototherapy/Ferroptosis/Chemodynamic Therapy DOI
Na An,

Shuanglong Tang,

Yuwei Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(32)

Published: March 27, 2024

Ferroptosis is an iron-dependent and lipid peroxides (LPO)-overloaded programmed damage cell death, induced by glutathione (GSH) depletion peroxide 4 (GPX4) inactivation. However, the inadequacy of endogenous iron reactive oxygen species (ROS) restricts efficacy ferroptosis. To overcome this obstacle, a near-infrared photo-responsive FeP@PEG NPs fabricated. Exogenous pool can enhance effect ferroptosis via GSH further regulate GPX4 Generation ·OH derived from Fenton reaction proved increased accumulation peroxides. The heat generated photothermal therapy ROS photodynamic apoptosis under (NIR-808 nm) irradiation, as evidenced mitochondrial dysfunction content. significantly inhibit growth several types cancer cells in vitro vivo, which validated theoretical experimental results. Meanwhile, show excellent T2-weighted magnetic resonance imaging (MRI) property. In summary, FeP-based nanotheranostic platform for enhanced phototherapy/ferroptosis/chemodynamic provides reliable opportunity clinical theranostics.

Language: Английский

Citations

7