Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215654 - 215654

Published: Jan. 20, 2024

Language: Английский

---

Tumor Microenvironment—A Short Review of Cellular and Interaction Diversity

Biology, Journal Year: 2022, Volume and Issue: 11(6), P. 929 - 929

Published: June 18, 2022

The tumor microenvironment is a complex network of various interactions between immune cells and non-cellular components such as the extracellular matrix, exosomes interleukins. Moreover, heterogeneity its constant modification may alter immunophenotype become responsible for resistance regarding therapies applied However, it should be remembered that in strongly immunosuppressive neoplastic microenvironment, system undergo reprogramming most often cease to fulfill their original function. Therefore, understanding what happens within which mechanisms are development progression let us know how cancer could protect itself against system. presented review summarizes latest information on cellular components, well impact development, exhaustion.

Language: Английский

---

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(23), P. 9759 - 9830

Published: Jan. 1, 2022

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.

Language: Английский

---

A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 348, P. 660 - 671

Published: June 20, 2022

Language: Английский

---

Rigid Shell Decorated Nanodevice with Fe/H₂O₂ Supply and Glutathione Depletion Capabilities for Potentiated Ferroptosis and Synergized Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(27)

Published: April 2, 2023

Abstract The overexpressed glutathione peroxidase4 (GPX4) and insufficient H 2 O in tumor cells weaken ferroptosis therapy the elicited anticancer immune response. Herein, a rigid metal‐polyphenol shell decorated nanodevice ssPPE Lap @Fe‐TA is constructed to successfully overcome drawbacks of therapy. consists Fe‐TA network‐based disulfide‐containing polyphosphoester (ssPPE) core with β‐lapachone loading. enables its efficient internalization by cell then disintegrates acidic endosome/lysosome initiate Fe 3+ /Fe 2+ conversion‐driven ferroptosis. will deplete (GSH) via disulfide‐thiol exchange reaction inactivate GPX4, also trigger release significantly increase intracellular promote ‐mediated Fenton reaction, eventually achieving strong inhibition progression. Moreover, elicites robust systemic antitumor response promoting dendritic (DCs) maturation T infiltration, synergizes anti‐PD‐L1 antibody (a‐PD‐L1) strikingly suppress 4T1 growth lung metastasis.

Language: Английский

---

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1944 - 1944

Published: July 14, 2023

Herbal chemicals with a long history in medicine have attracted lot of attention. Flavonolignans and flavonoids are considered as two classes the above-mentioned compounds different functional groups which exhibit several therapeutic capabilities such antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anticancer activities. Based on studies, high hydrophobic properties aforementioned limit their bioavailability inside human body restrict wide application. Nanoscale formulations solid lipid nanoparticles, liposomes, other types lipid-based delivery systems been introduced to overcome challenges. This approach allows be encapsulated between structures, resulting improving bioavailability. The enhanced system improves targeted sites reduces daily required dosage. Lowering dose performance drug by diminishing its side effects non-targeted tissues. present study aims highlight recent improvements implementing nanocarriers deliver flavonolignans flavonoids.

Language: Английский

---

Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

Nano Today, Journal Year: 2023, Volume and Issue: 51, P. 101931 - 101931

Published: July 11, 2023

Language: Английский

---

Protoporphyrin-sensitized degradable bismuth nanoformulations for enhanced sonodynamic oncotherapy

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 158, P. 637 - 648

Published: Jan. 5, 2023

Language: Английский

---

Pillararene-Based Supramolecular Polymers for Cancer Therapy

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1470 - 1470

Published: Feb. 3, 2023

Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular with tunable physicochemical properties, self-healing, externally stimulated responses. Among them, pillararene-based show great potential for biomedical applications fascinating host–guest easy modification. Herein, we summarize the state art cancer therapy illustrate its developmental trend future perspective.

Language: Английский

---

Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215570 - 215570

Published: Nov. 24, 2023

Language: Английский

---