Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104496 - 104496
Published: April 20, 2023
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)
Published: July 21, 2023
Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward
Language: Английский
Citations
94
Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(1), P. 108740 - 108740
Published: June 27, 2023
Language: Английский
Citations
28
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)
Published: June 6, 2024
Abstract The recent success of gene therapy during the COVID‐19 pandemic has underscored importance effective and safe delivery systems. Complementing lipid‐based systems, polymers present a promising alternative for delivery. Significant advances have been made in past, with multiple clinical trials progressing beyond phase I several companies actively working on polymeric systems which provides assurance that carriers can soon achieve translation. massive advantage structural tunability vast chemical space is being leveraged to mitigate shortcomings traditional polycationic improve translatability Tailored approaches diverse nucleic acids specific subcellular targets are now designed therapeutic efficacy. This review describes polymer design improved by polyplexes covalent polymer‐nucleic acid conjugates. also offers brief note novel computational techniques design. concludes an overview current state therapies clinic as well future directions their translation clinic.
Language: Английский
Citations
15
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(9), P. 2340 - 2345
Published: Jan. 1, 2023
This highlight discusses a recent study reported by Quan, Jiang and co-workers where new class of macrocyclic arenes with well-defined cavities, namely methylene-bridged naphthotubes, were prepared.
Language: Английский
Citations
16
Exploration, Journal Year: 2023, Volume and Issue: 4(1)
Published: Dec. 22, 2023
Abstract Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum ( F. ), spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with occurrence, progression, chemoresistance and immunosuppressive microenvironment CRC. Furthermore, can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it crucial develop efficacious non‐antibiotic approaches eradicate for treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, vaccines, have proposed combat biofilms. review summarizes latest advancements in anti‐ research, elucidates mechanisms employed these systems, discusses benefits drawbacks each technology. Additionally, this also provides an outlook specificity, potential clinical implications, challenges, future improvements strategies treatment
Language: Английский
Citations
13
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4077 - 4077
Published: April 6, 2024
Stimuli-responsive supramolecular polymers are ordered nanosized materials that held together by non-covalent interactions (hydrogen-bonding, metal-ligand coordination, π-stacking and, host–guest interactions) and can reversibly undergo self-assembly. Their nature endows with the ability to respond external stimuli (temperature, light, ultrasound, electric/magnetic field) or environmental changes pH, redox potential, enzyme activity), making them attractive candidates for a variety of biomedical applications. To date, research has largely evolved in development smart water-soluble self-assemblies aim mimicking biological function natural systems. Indeed, there is wide synthetic biomaterials formulated responsiveness control trigger, not aqueous The design responsive ranges from use hydrophobic cores (i.e., benzene-1,3,5-tricarboxamide) introduction macrocyclic hosts cyclodextrins). In this review, we summarize most relevant advances achieved stimuli-responsive systems used transport release both diagnosis agents therapeutic drugs order prevent, diagnose, treat human diseases.
Language: Английский
Citations
5
Cancer Drug Resistance, Journal Year: 2023, Volume and Issue: 6(4), P. 805 - 27
Published: Nov. 22, 2023
Cancer drug resistance has become one of the main challenges for failure chemotherapy, greatly limiting selection and use anticancer drugs dashing hopes cancer patients. The emergence supramolecular host-guest nanosystems brought field chemistry into nanoworld, providing a potential solution to this challenge. Compared with conventional chemotherapeutic platforms, can reverse by increasing uptake, reducing efflux, activating drugs, inhibiting DNA repair. Herein, we summarize research progress overcoming discuss future direction in field. It is hoped that review will provide more positive references promoting development nanosystems.
Language: Английский
Citations
12
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 9, 2024
Abstract Different from most of the conventional platforms with dissatisfactory theranostic capabilities, supramolecular nanotheranostic systems have unparalleled advantages via artful combination chemistry and nanotechnology. Benefiting tunable stimuli-responsiveness compatible hierarchical organization, host–guest interactions developed into popular mainstay for constructing nanoplatforms. Characterized by strong diverse complexation property, cucurbit[8]uril (CB[8]) shows great potential as important building blocks systems. In this review, we summarize recent progress CB[8]-based theranostics regarding design, manufacture mechanism. Meanwhile, current limitations corresponding reasonable solutions well future development are also discussed. Graphical
Language: Английский
Citations
4
Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Here we summarize the progress of developing crystalline porous framework materials with supramolecular macrocycles for their applications in solid state, guiding readers through future chemistry, and commercialization.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141373 - 141373
Published: Feb. 21, 2025
Language: Английский
Citations
0