Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: June 20, 2022

Abstract In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not ICIs, partly caused absence of tumor-infiltrating lymphocytes (TILs), significantly limits application ICIs. Converting these “cold” into “hot” may ICIs is an unsolved question immunotherapy. Since it a general characteristic cancers resist apoptosis, induction non-apoptotic regulated cell death (RCD) emerging as new treatment strategy. Recently, several studies have revealed interaction between RCD and antitumor immunity. Specifically, autophagy, ferroptosis, pyroptosis, necroptosis exhibit synergistic responses while possibly exerting inhibitory effects on responses. Thus, targeted therapies (inducers inhibitors) against combination with exert potent activity, resistant This review summarizes multilevel relationship immunity RCD, including necroptosis, potential targeting improve efficacy malignancy.

Language: Английский

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Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 8, 2022

Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.

Language: Английский

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Covalent organic frameworks for photocatalysis: Synthesis, structural features, fundamentals and performance

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214889 - 214889

Published: Oct. 15, 2022

Language: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 273 - 285

Published: March 12, 2022

Language: Английский

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Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 15, 2023

Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting effect cancer immunotherapy. Pyroptosis, lytic programmed cell-death pathway unlike apoptosis, considered type immunogenic cell death (ICD) that can intensify ICD process cells, releasing dramatically increased tumor-associated antigens damage-associated molecular patterns promote Herein, membrane-targeted aggregation-induced emission photosensitive dimer found be able achieve highly efficient under synergistic photodynamic photothermal therapy. The efficiently produce type-I reactive oxygen species (ROS) by therapy hypoxic tissue, leading pyroptosis direct membrane damage, which further reinforced its effect. Furthermore, enhanced based on completely eliminate primary seventh day treatment also boost systemic antitumor immunity generating immune memory, demonstrated superior therapeutic effects both solid tumors metastatic when healing 4T1 mouse models with poor immunogenicity.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Ultrasound‐Amplified Enzyodynamic Tumor Therapy by Perovskite Nanoenzyme‐Enabled Cell Pyroptosis and Cascade Catalysis

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(7)

Published: Nov. 22, 2022

Overcoming apoptosis resistance to achieve efficient breast cancer treatment remains a challenge. The precise induction of another form programmed cell death, pyroptosis, is an excellent alternative for treating cancer. Ultrasound (US)-enhanced enzyme dynamic (enzyodynamic) therapy developed by employing LaFeO3 (LFO) perovskite nanocrystals as substrate increase the rate deleterious reactive oxygen species (ROS) generation intensive pyroptosis. LFO possess quadruple enzyme-mimicking activities, including oxidase-, peroxidase-, glutathione and catalase-mimicking which undertake dominant therapeutic task through cascade catalytic reactions, reversal hypoxic microenvironment, depletion endogenous glutathione, continuous output ROS. US exogenous stimulation increases transition intermediate complex Fe (II) favors incremental ROS production, burst-induced pyroptosis process accomplished ROS-TXNIP-NLRP3-GSDMD pathway. Both in vitro vivo antineoplastic outcomes affirm ascendancy nanozyme-induced This work highlights critical role coupled with nanocatalytic reactors pyroptosis-dominant circumvention feature.

Language: Английский

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Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 2, 2023

Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable triggering both ferroptosis remains limited. Here we show construction a covalent organic framework (COF-919) from planar twisted AIEgen-based motifs dual-inducer for efficient Mechanistic studies reveal that COF-919 displays stronger near-infrared light absorption, lower band energy, longer lifetime to favor generation reactive oxygen species (ROS) photothermal conversion, pyroptosis. Because its good ROS production capability, it upregulates intracellular lipid peroxidation, leading glutathione depletion, low expression peroxidase 4, induction ferroptosis. Additionally, by effectively inhibits tumor metastasis recurrence, resulting in over 90% growth inhibition cure rates exceeding 80%.

Language: Английский

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