Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug DOI Open Access
Wei Gao, Yan Wang, Yuanyi Zheng

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(6), P. 687 - 698

Published: April 5, 2024

ConspectusNanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine on drug carriers: how to improve efficacy reduce side effects. In order further the synergistic detoxifying effects nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components ignores between components. lack in-depth research bioactivities nanocarriers hinders development clinical translation nanomedicine.In past decade, gradually discovered nanomaterials show excellent bioactivities, becoming enormous treasure trove for disease prevention treatment. Among numerous bioactive Prussian blue (PB) antidote approved by US Food Drug Administration, showing biosafety. clinically PB owns many drawbacks, it difficult satisfy requirements When size reduces nanoscale, nano shows both unique properties enhancement its performance bioactivities. Due easy-to-regulate structure rich iron suspended bonds, may be potential delivery system. Electron transition in Fe-CN-Fe endows with strong absorbance near-infrared region, photothermal conversion agent. Furthermore, due redox catalytic activities, great translational clinic prospect.In this Account, we describe our exploration as agent, system treatment over decade. We first summarize application agent cancer, then recent progress diseases (such tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative gastrointestinal skin lesions). Finally, look forward open challenges future developments rapidly developing field. hope Account will help readers understand not only carrier but also drug, thus realizing These studies provide paradigm nanomaterials. As other teams continue explore promising material, characteristics represented bring exciting

Language: Английский

Nanozymes for nanohealthcare DOI
Yihong Zhang, Gen Wei, W. Liu

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: May 30, 2024

Language: Английский

Citations

81
Spatial Position Regulation of Cu Single Atom Site Realizes Efficient Nanozyme Photocatalytic Bactericidal Activity DOI Open Access
Honghui Ou, Yuping Qian, Lintian Yuan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(46)

Published: July 27, 2023

Recently, single-atom nanozymes have made significant progress in the fields of sterilization and treatment, but their catalytic performance as substitutes for natural enzymes drugs is far from satisfactory. Here, a method reported to improve enzyme activity by adjusting spatial position site on nanoplatforms. Two types Cu are synthesized interlayer (CuL /PHI) in-plane (CuP poly (heptazine imide) (PHI) through different synthesis pathways. Experimental theoretical analysis indicates that PHI can effectively adjust coordination number, bond length, electronic structure single atoms compared position, thereby promoting photoinduced electron migration O2 activation, enabling effective generate reactive oxygen species (ROS). Under visible light irradiation, photocatalytic bactericidal CuL /PHI against aureus ≈100%, achieving same antibacterial effect antibiotics, after 10 min low-dose exposure 2 h incubation.

Language: Английский

Citations

74
Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes DOI Creative Commons
Lu Yang, Shuming Dong, Shili Gai

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

Citations

74
A Cardiac‐Targeted Nanozyme Interrupts the Inflammation‐Free Radical Cycle in Myocardial Infarction DOI
Xueliang Liu, Binghua Chen, Jingqi Chen

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 21, 2023

Abstract Severe systemic inflammation following myocardial infarction (MI) is a major cause of patient mortality. MI‐induced can trigger the production free radicals, which in turn ultimately leads to increased cardiac lesions (i.e., inflammation‐free radicals cycle), resulting heart failure and death. However, currently available anti‐inflammatory drugs have limited efficacy due their weak effect poor accumulation at site. Herein, novel Fe‐Cur@TA nanozyme developed for targeted therapy MI, generated by coordinating Fe 3+ drug curcumin (Cur) with further modification tannic acid (TA). Such exhibits excellent scavenging properties reducing immune cell infiltration, promoting macrophage polarization toward M2‐like phenotype, suppressing inflammatory cytokine secretion, blocking cycle. Furthermore, high affinity TA tissue, shows an almost tenfold greater retention uptake than Fe‐Cur. In mouse preclinical beagle dog MI models, preserves function reduces scar size, suggesting promising potential clinical translation cardiovascular disease.

Language: Английский

Citations

62
A Photomodulable Bacteriophage‐Spike Nanozyme Enables Dually Enhanced Biofilm Penetration and Bacterial Capture for Photothermal‐Boosted Catalytic Therapy of MRSA Infections DOI Creative Commons
Haibin Wu, Min Wei, Shen Hu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 13, 2023

Nanozymes, featuring intrinsic biocatalytic effects and broad-spectrum antimicrobial properties, are emerging as a novel antibiotic class. However, prevailing bactericidal nanozymes face challenging dilemma between biofilm penetration bacterial capture capacity, significantly impeding their antibacterial efficacy. Here, this work introduces photomodulable nanozyme (ICG@hMnO

Language: Английский

Citations

55
Bioinspired construction of histidine-doped porphyrin covalent organic framework nanozyme with enhanced peroxidase-like activity for sensitive uric acid detection DOI
Chao Zhong,

Cong Hu,

Dan Ouyang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 146979 - 146979

Published: Oct. 28, 2023

Language: Английский

Citations

48
Recent Development of Copper‐Based Nanozymes for Biomedical Applications DOI
Xin Yu, Yawen Wang, Jian Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

Citations

46
Two-Site Enhanced Porphyrinic Metal–Organic Framework Nanozymes and Nano-/Bioenzyme Confined Catalysis for Colorimetric/Chemiluminescent Dual-Mode Visual Biosensing DOI
Huining Chai, Yujie Li, Kun Yu

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(44), P. 16383 - 16391

Published: Oct. 26, 2023

The rational design of efficient nanozymes and the immobilization enzymes are great significance for construction high-performance biosensors based on nano-/bioenzyme catalytic systems. Herein, a novel V-TCPP(Fe) metal-organic framework nanozyme with two-dimensional nanosheet morphology is rationally designed by using V2CTx MXene as metal source iron tetrakis(4-carboxyphenyl)porphine (FeTCPP) ligand an organic linker. It exhibits enhanced peroxidase- catalase-like activities luminol-H2O2 chemiluminescent (CL) behavior. Based experimental theoretical results, these excellent enzyme-like derived from two-site synergistic effect between V nodes FeTCPP ligands in V-TCPP(Fe). Furthermore, confined system developed zeolitic imidazole (ZIF) coencapsulation bioenzyme. Using acetylcholinesterase (AChE) model, our constructed V-TCPP(Fe)/AChE@ZIF was successfully used colorimetric/CL dual-mode visual biosensing organophosphorus pesticides. This work expected to provide new insights into systems, encouraging applications catalysis biosensing.

Language: Английский

Citations

46
Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration DOI Creative Commons
Amal George Kurian, Rajendra K. Singh,

Varsha Sagar

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

Citations

41
Electron Lock Manipulates the Catalytic Selectivity of Nanozyme DOI
Guopeng Xu, Kehan Liu,

Bingqing Jia

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3814 - 3825

Published: Jan. 17, 2024

Nanomaterials with enzyme-mimicking functions, termed nanozymes, offer attractive opportunities for biocatalysis and biomedicine. However, manipulating nanozyme selectivity poses an insurmountable hurdle. Here, we propose the concept of energy-governed electron lock that controls transfer between substrates to achieve manipulation enzyme-like catalysis. An can be constructed opened, via modulating nanozyme's energy match barrier enzymatic reactions. iron-doped carbon dot (FeCD) easy-to-regulate is selected as a proof concept. Through regulating conduction band which dominates energy, activatable oxidase selective peroxidase (POD) substrate affinity 123-fold higher than natural horseradish (HRP) achieved. Furthermore, while maintaining selectivity, FeCDs exhibit catalytic kinetics comparable HRP upon transforming photons into electrons. Superior efficient catalysis, undetectable biotoxicity energize potent targeted drugs on antibiotic-resistant bacterial abscesses. provides robust strategy manipulate toward advanced nanozymes.

Language: Английский

Citations

33