Accounts of Materials Research,
Journal Year:
2024,
Volume and Issue:
5(6), P. 687 - 698
Published: April 5, 2024
ConspectusNanomedicine
is
an
interdisciplinary
science
that
involves
chemistry,
materials,
physics,
engineering,
biology,
and
medicine.
The
main
focus
of
nanomedicine
on
drug
carriers:
how
to
improve
efficacy
reduce
side
effects.
In
order
further
the
synergistic
detoxifying
effects
nanomedicines,
scientists
have
adopted
a
multifunctional
integration
strategy.
However,
versatility
brings
complex
components
ignores
between
components.
lack
in-depth
research
bioactivities
nanocarriers
hinders
development
clinical
translation
nanomedicine.In
past
decade,
gradually
discovered
nanomaterials
show
excellent
bioactivities,
becoming
enormous
treasure
trove
for
disease
prevention
treatment.
Among
numerous
bioactive
Prussian
blue
(PB)
antidote
approved
by
US
Food
Drug
Administration,
showing
biosafety.
clinically
PB
owns
many
drawbacks,
it
difficult
satisfy
requirements
When
size
reduces
nanoscale,
nano
shows
both
unique
properties
enhancement
its
performance
bioactivities.
Due
easy-to-regulate
structure
rich
iron
suspended
bonds,
may
be
potential
delivery
system.
Electron
transition
in
Fe-CN-Fe
endows
with
strong
absorbance
near-infrared
region,
photothermal
conversion
agent.
Furthermore,
due
redox
catalytic
activities,
great
translational
clinic
prospect.In
this
Account,
we
describe
our
exploration
as
agent,
system
treatment
over
decade.
We
first
summarize
application
agent
cancer,
then
recent
progress
diseases
(such
tumors,
neurodegeneration,
cerebrovascular
disease,
bone-related
degenerative
gastrointestinal
skin
lesions).
Finally,
look
forward
open
challenges
future
developments
rapidly
developing
field.
hope
Account
will
help
readers
understand
not
only
carrier
but
also
drug,
thus
realizing
These
studies
provide
paradigm
nanomaterials.
As
other
teams
continue
explore
promising
material,
characteristics
represented
bring
exciting
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(46)
Published: July 27, 2023
Recently,
single-atom
nanozymes
have
made
significant
progress
in
the
fields
of
sterilization
and
treatment,
but
their
catalytic
performance
as
substitutes
for
natural
enzymes
drugs
is
far
from
satisfactory.
Here,
a
method
reported
to
improve
enzyme
activity
by
adjusting
spatial
position
site
on
nanoplatforms.
Two
types
Cu
are
synthesized
interlayer
(CuL
/PHI)
in-plane
(CuP
poly
(heptazine
imide)
(PHI)
through
different
synthesis
pathways.
Experimental
theoretical
analysis
indicates
that
PHI
can
effectively
adjust
coordination
number,
bond
length,
electronic
structure
single
atoms
compared
position,
thereby
promoting
photoinduced
electron
migration
O2
activation,
enabling
effective
generate
reactive
oxygen
species
(ROS).
Under
visible
light
irradiation,
photocatalytic
bactericidal
CuL
/PHI
against
aureus
≈100%,
achieving
same
antibacterial
effect
antibiotics,
after
10
min
low-dose
exposure
2
h
incubation.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Nov. 21, 2023
Abstract
Severe
systemic
inflammation
following
myocardial
infarction
(MI)
is
a
major
cause
of
patient
mortality.
MI‐induced
can
trigger
the
production
free
radicals,
which
in
turn
ultimately
leads
to
increased
cardiac
lesions
(i.e.,
inflammation‐free
radicals
cycle),
resulting
heart
failure
and
death.
However,
currently
available
anti‐inflammatory
drugs
have
limited
efficacy
due
their
weak
effect
poor
accumulation
at
site.
Herein,
novel
Fe‐Cur@TA
nanozyme
developed
for
targeted
therapy
MI,
generated
by
coordinating
Fe
3+
drug
curcumin
(Cur)
with
further
modification
tannic
acid
(TA).
Such
exhibits
excellent
scavenging
properties
reducing
immune
cell
infiltration,
promoting
macrophage
polarization
toward
M2‐like
phenotype,
suppressing
inflammatory
cytokine
secretion,
blocking
cycle.
Furthermore,
high
affinity
TA
tissue,
shows
an
almost
tenfold
greater
retention
uptake
than
Fe‐Cur.
In
mouse
preclinical
beagle
dog
MI
models,
preserves
function
reduces
scar
size,
suggesting
promising
potential
clinical
translation
cardiovascular
disease.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(24)
Published: June 13, 2023
Nanozymes,
featuring
intrinsic
biocatalytic
effects
and
broad-spectrum
antimicrobial
properties,
are
emerging
as
a
novel
antibiotic
class.
However,
prevailing
bactericidal
nanozymes
face
challenging
dilemma
between
biofilm
penetration
bacterial
capture
capacity,
significantly
impeding
their
antibacterial
efficacy.
Here,
this
work
introduces
photomodulable
nanozyme
(ICG@hMnO
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(44), P. 16383 - 16391
Published: Oct. 26, 2023
The
rational
design
of
efficient
nanozymes
and
the
immobilization
enzymes
are
great
significance
for
construction
high-performance
biosensors
based
on
nano-/bioenzyme
catalytic
systems.
Herein,
a
novel
V-TCPP(Fe)
metal-organic
framework
nanozyme
with
two-dimensional
nanosheet
morphology
is
rationally
designed
by
using
V2CTx
MXene
as
metal
source
iron
tetrakis(4-carboxyphenyl)porphine
(FeTCPP)
ligand
an
organic
linker.
It
exhibits
enhanced
peroxidase-
catalase-like
activities
luminol-H2O2
chemiluminescent
(CL)
behavior.
Based
experimental
theoretical
results,
these
excellent
enzyme-like
derived
from
two-site
synergistic
effect
between
V
nodes
FeTCPP
ligands
in
V-TCPP(Fe).
Furthermore,
confined
system
developed
zeolitic
imidazole
(ZIF)
coencapsulation
bioenzyme.
Using
acetylcholinesterase
(AChE)
model,
our
constructed
V-TCPP(Fe)/AChE@ZIF
was
successfully
used
colorimetric/CL
dual-mode
visual
biosensing
organophosphorus
pesticides.
This
work
expected
to
provide
new
insights
into
systems,
encouraging
applications
catalysis
biosensing.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 3814 - 3825
Published: Jan. 17, 2024
Nanomaterials
with
enzyme-mimicking
functions,
termed
nanozymes,
offer
attractive
opportunities
for
biocatalysis
and
biomedicine.
However,
manipulating
nanozyme
selectivity
poses
an
insurmountable
hurdle.
Here,
we
propose
the
concept
of
energy-governed
electron
lock
that
controls
transfer
between
substrates
to
achieve
manipulation
enzyme-like
catalysis.
An
can
be
constructed
opened,
via
modulating
nanozyme's
energy
match
barrier
enzymatic
reactions.
iron-doped
carbon
dot
(FeCD)
easy-to-regulate
is
selected
as
a
proof
concept.
Through
regulating
conduction
band
which
dominates
energy,
activatable
oxidase
selective
peroxidase
(POD)
substrate
affinity
123-fold
higher
than
natural
horseradish
(HRP)
achieved.
Furthermore,
while
maintaining
selectivity,
FeCDs
exhibit
catalytic
kinetics
comparable
HRP
upon
transforming
photons
into
electrons.
Superior
efficient
catalysis,
undetectable
biotoxicity
energize
potent
targeted
drugs
on
antibiotic-resistant
bacterial
abscesses.
provides
robust
strategy
manipulate
toward
advanced
nanozymes.