Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(13)
Published: Feb. 3, 2023
Bacterial
biofilms
are
linked
to
several
diseases
and
cause
resistant
chronic
infections
in
immune-compromised
patients.
Nanomotors
comprise
a
new
field
of
research
showing
great
promise
within
biomedicine
but
pose
challenges
terms
biocompatibility.
propelled
by
thermophoresis
could
overcome
this
challenge,
as
they
leave
no
waste
product
during
propulsion.
In
study,
mesoporous-silica
nanoparticles
coated
with
thin
layer
gold
make
nanomotors,
which
can
be
driven
near-infrared
(NIR)
light
irradiation.
The
prepared
mesoporous
SiO
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: May 19, 2023
Drug
combination
provides
an
efficient
pathway
to
combat
drug
resistance
in
bacteria
and
bacterial
biofilms.
However,
the
facile
methodology
construct
combinations
their
applications
nanocomposites
is
still
lacking.
Here
two-tailed
antimicrobial
amphiphiles
(T2
A2
)
composed
of
nitric
oxide
(NO)-donor
(diethylenetriamine
NONOate,
DN)
various
natural
aldehydes
are
reported.
T2
self-assemble
into
nanoparticles
due
amphiphilic
nature,
with
remarkably
low
critical
aggregation
concentration.
The
representative
cinnamaldehyde
(Cin)-derived
(Cin-T2
assemblies
demonstrate
excellent
bactericidal
efficacy,
notably
higher
than
free
Cin
DN.
Cin-T2
kill
multidrug-resistant
staphylococci
eradicate
biofilms
via
multiple
mechanisms,
as
proved
by
mechanism
studies,
molecular
dynamics
simulations,
proteomics,
metabolomics.
Furthermore,
rapidly
alleviate
inflammation
subsequent
murine
infection
models.
Together,
may
provide
efficient,
non-antibiotic
alternative
combating
ever-increasing
threat
drug-resistant
Advanced Materials Interfaces,
Journal Year:
2023,
Volume and Issue:
10(24)
Published: July 20, 2023
Abstract
The
recent
COVID‐19
pandemic
and
the
accelerating
rise
of
deaths
associated
with
antibiotic‐resistant
bacterial
strains
have
highlighted
global
health
economic
threats
caused
by
super
spreading
pathogens.
A
major
route
transmission
for
pathogens
is
via
surfaces
contaminated
touch
or
droplets
generated
sneezing
coughing.
Current
surface
disinfection
strategies
are
having
diminishing
efficacy,
due
to
increasing
number
superbugs
short‐lasting
effect
disinfectants
resulting
in
recontamination.
New
inhibiting
surface‐mediated
pathogen
focus
significant
multi‐disciplinary
efforts.
Among
those,
development
superhydrophobic
(SHS)
increasingly
regarded
as
a
powerful
alternative,
additive,
antimicrobial
strategies.
SHS
provide
neutral/inert
interface
that
can
prevent
viral
colonization.
Here,
use
such
water‐repellent
coatings
critically
reviewed
impede
pathogens,
addressing
challenges
future
directions
their
translation
into
real‐world
settings.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(17)
Published: July 20, 2023
Abstract
The
discovery
of
antibiotics
has
saved
millions
lives,
but
the
emergence
antibiotic‐resistant
bacteria
become
another
problem
in
modern
medicine.
To
avoid
or
reduce
overuse
antibacterial
treatments,
stimuli‐responsive
materials,
pathogen‐targeting
nanoparticles,
immunogenic
nano‐toxoids,
and
biomimetic
materials
are
being
developed
to
make
sterilization
better
smarter
than
conventional
therapies.
common
goal
smart
(SAMs)
is
increase
antibiotic
efficacy
function
via
an
mechanism
different
from
that
order
biological
properties
while
reducing
risk
drug
resistance.
research
development
SAMs
increasingly
interdisciplinary
because
new
designs
require
knowledge
fields
input/collaboration
scientists
fields.
A
good
understanding
energy
conversion
physiological
characteristics
cells
bacteria,
bactericidal
structures
components
nature
expected
promote
SAMs.
In
this
review,
importance
multidisciplinary
insights
for
emphasized,
latest
advances
categorized
discussed
according
pertinent
disciplines
including
science,
physiology,
biomimicry.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(15)
Published: Jan. 25, 2023
Abstract
Untethered
mobile
micro‐/nanomotors
(MNMs),
as
newly‐emerging
attractive
and
versatile
nanotechnologies,
are
expected
to
be
the
next‐generation
disease
treatment
tools,
for
breaking
through
limitations
of
conventional
passive
drug
delivery
manner.
However,
advances
in
these
fascinating
platforms
have
been
hampered
by
complexity
biological
environment
particularity
microenvironment.
Consequently,
specific
design
strategies
clinical
imaging
techniques
essential
ensure
high‐efficiency
biomedical
MNMs
on
actuation,
targeting,
localization,
therapy
when
performing
assigned
vivo
tasks.
This
review
thus
comprehensively
addresses
three
aspects
MNMs,
including
design,
imaging,
treatment,
highlighting
intelligent
with
biomimetic
functionality
chemotactic
capability,
emphasizing
applicability
different
techniques,
focusing
various
proof‐of‐concept
studies
based
physiological
characteristics
major
diseases.
In
addition,
key
challenges
current
addressed,
which
may
inspire
future
research
facilitate
translation
toward
treatment.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(13)
Published: Feb. 3, 2023
Bacterial
biofilms
are
linked
to
several
diseases
and
cause
resistant
chronic
infections
in
immune-compromised
patients.
Nanomotors
comprise
a
new
field
of
research
showing
great
promise
within
biomedicine
but
pose
challenges
terms
biocompatibility.
propelled
by
thermophoresis
could
overcome
this
challenge,
as
they
leave
no
waste
product
during
propulsion.
In
study,
mesoporous-silica
nanoparticles
coated
with
thin
layer
gold
make
nanomotors,
which
can
be
driven
near-infrared
(NIR)
light
irradiation.
The
prepared
mesoporous
SiO
