Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 17, 2023

Abstract Having a hypoxic microenvironment is common and salient feature of most solid tumors. Hypoxia has profound effect on the biological behavior malignant phenotype cancer cells, mediates effects chemotherapy, radiotherapy, immunotherapy through complex mechanisms, closely associated with poor prognosis in various patients. Accumulating studies have demonstrated that normalization tumor vasculature, nanoparticle carriers biocarriers can effectively increase oxygen concentration microenvironment, improve drug delivery efficacy radiotherapy. They also infiltration innate adaptive anti-tumor immune cells to enhance immunotherapy. Furthermore, drugs targeting key genes hypoxia, including hypoxia tracers, hypoxia-activated prodrugs, hypoxia-inducible factors downstream targets, be used for visualization quantitative analysis antitumor activity. However, relationship between an area research requires further exploration. Here, we investigated potential development cancer, changes signaling pathways occur adapt environments, mechanisms hypoxia-induced tolerance, chemotherapeutic enhanced radiation as well insights applications therapy.

Language: Английский

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Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 23, 2023

Abstract Hypoxia is a persistent physiological feature of many different solid tumors and key driver malignancy, in recent years, it has been recognized as an important target for cancer therapy. occurs the majority due to poor vascular oxygen supply that not sufficient meet needs rapidly proliferating cells. A hypoxic tumor microenvironment (TME) can reduce effectiveness other therapies, such radiotherapy, chemotherapy, immunotherapy. In this review, we discuss critical role hypoxia development, including metabolism, immunity, angiogenesis. The treatment methods TME are summarized, hypoxia‐targeted therapy improving oxygenation by alleviating itself. Hyperoxia be used improve tissue partial pressure relieve hypoxia. We focus on underlying mechanisms hyperoxia their impact current therapies prospects treatment.

Language: Английский

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Ligand engineering of Au₄₄nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy

Chemical Science, Journal Year: 2023, Volume and Issue: 14(16), P. 4308 - 4318

Published: Jan. 1, 2023

Developing a high-performance noninvasive probe for precise cancer theranostics is very challenging but urgently required. Herein, novel Au nanoclusters (NCs)-based was designed via ligand engineering by conjugating photoluminescent (PL) Au44 NCs in the second near-infrared window (NIR-II, 1000-1700 nm) with aromatic photoacoustic (PA)/photothermal molecules through click chemistry. This design bypasses incompatibility dilemma between photoluminescence attributes and PA/photothermal properties because rigidity of can lead to aggregation-induced emission (AIE) Au(i)-ligand shell constraining their nonradiative relaxation. Benefiting from strong NIR-II PL emissions at 1080 1240 nm, high photothermal conversion efficiency (65.12%), low cytotoxicity, appropriate renal clearance, enhanced permeability retention (EPR) effect, as-designed NC-based theranostic achieves ultradeep PL/PA imaging-guided therapy (PTT). Remarkably, 16 days after treatment guided imaging, mice were all healed without tumor recurrence, while average life span control groups only 17-21 days. study interesting it provides paradigm designing metal probe, may add fundamentally methodologically disease therapy.

Language: Английский

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Oxygen‐driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 4, 2024

Abstract The immunological implications of cuproptosis, a form cell death highly sensitive to oxygen presence, remain largely unexplored in the context tumor immunotherapy. Herein, we initially investigate positive correlation between cuproptosis and immunotherapy through bioinformatics analysis. Subsequently, an generator loaded with copper ions ( Cu/AP H‐M) has been constructed, which serves as effective carrier crucially enhances oxygenation microenvironment. Importantly, H‐M‐mediated dual strengthening radiotherapy could not only trigger powerful antitumor immunity related immunogenic by RNA‐sequencing analysis, but also effectively inhibit growth both distal situ low rectal tumors after combined immunotherapy, creating robust immune memory effect. Our work reveals beneficial effects enhanced radio‐immunotherapy elucidates its underlying mechanisms, provides novel approach for synergistic integration radiotherapy, broadening scope cuproptosis‐mediated therapy.

Language: Английский

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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

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Application of nanomedicine in radiotherapy sensitization

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 15, 2023

Radiation therapy is an important component of cancer treatment. As research in radiotherapy techniques advances, new methods to enhance tumor response radiation need be on the agenda enable enhanced at low doses. With rapid development nanotechnology and nanomedicine, use nanomaterials as radiosensitizers overcome resistance has attracted great interest. The application emerging biomedical field offers good opportunities improve efficacy radiotherapy, which helps promote will applied clinical practice near future. In this paper, we discuss main types nano-radiosensitizers explore their sensitization mechanisms tissue level, cellular level even molecular biology genetic analyze current status promising provide outlook future applications.

Language: Английский

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Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 25, 2024

Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high mechanical strength to penetrate skin. release was realized degradation HA, self‐monitor released actives based dynamic bright orange fluorescence emitted under ultraviolet radiation. As could destroy bacteria membranes, excellent vitro antibiosis ability. Based features, have demonstrated inhibition, residual self‐monitoring, healing promotion abilities Escherichia coli‐ or Staphylococcus aureus ‐infected These results indicated potential such applications.

Language: Английский

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Enzyme-mimic catalytic activities and biomedical applications of noble metal nanoclusters

Nanoscale, Journal Year: 2024, Volume and Issue: 16(17), P. 8196 - 8215

Published: Jan. 1, 2024

This review delves into enzyme-mimic catalysis of metal nanoclusters based on a hierarchical structure scheme reminiscent proteins. Biomedical applications established by the clusters have also been outlined.

Language: Английский

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In Situ Formed Microalgae-Integrated Living Hydrogel for Enhanced Tumor Starvation Therapy and Immunotherapy through Photosynthetic Oxygenation

Nano Letters, Journal Year: 2024, Volume and Issue: 24(12), P. 3801 - 3810

Published: March 13, 2024

The effectiveness of various cancer therapies for solid tumors is substantially limited by the highly hypoxic tumor microenvironment (TME). Here, a microalgae-integrated living hydrogel (ACG gel) developed to concurrently enhance hypoxia-constrained starvation therapy and immunotherapy. ACG gel formed in situ following intratumoral injection biohybrid fluid composed alginate, Chlorella sorokiniana, glucose oxidase, facilitated crossing-linking between divalent ions within alginate. microalgae sorokiniana embedded generate abundant oxygen through photosynthesis, enhancing oxidase-catalyzed consumption shifting TME from immunosuppressive immunopermissive status, thus reducing cell energy supply boosting antitumor immunity. In murine 4T1 models, significantly suppresses growth effectively prevents postoperative recurrence. This study, leveraging as natural oxygenerators, provides versatile universal strategy development oxygen-dependent therapies.

Language: Английский

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Recent advances of bimetallic nanoclusters with atomic precision for catalytic applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215692 - 215692

Published: Feb. 14, 2024

Language: Английский

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