Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(30)

Published: Aug. 26, 2023

Nitric oxide (NO) is a gaseous molecule that has central role in signaling pathways involved numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its form, NO short half-life, physiology concentration dependent, often restricting function target site. Providing from an external source beneficial promoting cellular functions treatment of different pathological conditions. Hence, the multifaceted pathology garnered massive interest developing strategies deliver exogenous for various regenerative biomedical complexities. NO-releasing platforms or donors capable delivering controlled sustained manner tissues organs have advanced past few decades. This review article discusses detail generation via enzymatic synthase as well multiple biological modulates. The methods incorporating into diverse biomaterials including physical, chemical, supramolecular techniques are summarized. Then, these highlighted terms advancing medical problems.

Language: Английский

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Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform

Bioelectronic Medicine, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 2, 2023

The fourth industrial revolution has led to the development and application of health monitoring sensors that are characterized by digitalization intelligence. These have extensive applications in medical care, personal management, elderly sports, other fields, providing people with more convenient real-time services. However, these face limitations such as noise drift, difficulty extracting useful information from large amounts data, lack feedback or control signals. artificial intelligence provided powerful tools algorithms for data processing analysis, enabling intelligent monitoring, achieving high-precision predictions decisions. By integrating Internet Things, intelligence, sensors, it becomes possible realize a closed-loop system functions collection, online diagnosis, treatment recommendations. This review focuses on healthcare enhanced technologies aspects materials, device structure, integration, scenarios. Specifically, this first introduces great advances wearable respiration rate, heart pulse, sweat, tears; implantable cardiovascular nerve signal acquisition, neurotransmitter monitoring; soft electronics precise therapy. Then, recent volatile organic compound detection highlighted. Next, current developments human-machine interfaces, AI-enhanced multimode self-sustainable systems reviewed. Last, perspective future directions further research is also provided. In summary, fusion will provide intelligent, convenient, secure services next-generation biomedical applications.

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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Enhanced Sonodynamic Cancer Therapy through Iron‐Doping and Oxygen‐Vacancy Engineering of Piezoelectric Bismuth Tungstate Nanosheets

Small, Journal Year: 2023, Volume and Issue: 19(24)

Published: March 15, 2023

Sonodynamic therapy (SDT) is regarded as a new-rising strategy for cancer treatment with low invasiveness and high tissue penetration, but the scarcity of high-efficiency sonosensitizers has seriously hindered its application. Herein, iron-doped oxygen-deficient bismuth tungstate nanosheets (BWO-Fe NSs) piezotronic effect are synthesized enhanced SDT. Due to existence oxygen defects introduced through Fe doping, bandgap BWO-Fe significantly narrowed so that can be more easily activated by exogenous ultrasound (US). The acting electron traps inhibit recombination US-induced electrons holes. More importantly, dynamically renewed piezoelectric potential facilitates migration holes opposite side causes energy band bending, which further promotes production reactive species. Furthermore, doping endows Fenton reactivity, converts hydrogen peroxide (H2 O2 ) in tumor microenvironment into hydroxyl radicals (•OH), thereby amplifying cellular oxidative damage enhancing Both vitro vivo experiments illustrate their cytotoxicity suppression rate against refractory breast mice. This work may provide an alternative develop SDT via metal ions.

Language: Английский

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Enhancing Deep‐Seated Melanoma Therapy through Wearable Self‐Powered Microneedle Patch

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(11)

Published: Dec. 20, 2023

Abstract Effective treatment of deep‐seated tumors relies on enhanced drug penetration in transdermal delivery systems. While microneedles (MNs) and iontophoresis techniques have shown improved efficiency, challenges such as skin elasticity, high electrical resistance the stratum corneum, external power supply requirements hinder their efficacy treating tumors. In this study, a wearable, self‐powered MN patch that integrates flexible triboelectric nanogenerator (F‐TENG) is presented, aimed at advancing tumor therapy. MNs are composed water‐soluble materials mixed with negatively charged pH‐responsive nanoparticles (NPs) loaded therapeutic drugs. The F‐TENG harnesses personal mechanical movements generate energy. Leveraging advantages both F‐TENG, NPs can penetrate deep locations upon insertion, releasing drugs rapidly acidic tissues. Owing to these features, single administration integrated MN‐patch mouse model melanoma exhibits superior inhibiting deep‐located compared using alone, indicating promising potential for sites.

Language: Английский

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Self‐Powered and Self‐Healable Extraocular‐Muscle‐Like Actuator Based on Dielectric Elastomer Actuator and Triboelectric Nanogenerator

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 26, 2023

Abstract Although dielectric elastomer actuators (DEAs) are promising artificial muscles for use as visual prostheses in patients with oculomotor nerve palsy (ONP), high driving voltage coupled vulnerable compliant electrodes limits their safe long‐term service. Herein, a self‐healable polydimethylsiloxane electrode based on reversible imine bonds and hydrogen is prepared coated an acrylic ester film to develop DEA (SDEA), followed by actuation high‐output triboelectric nanogenerator (TENG) construct self‐powered (TENG‐SDEA). Under 135.9 kV mm −1 , the SDEA exhibits elevated actuated strain of 50.6%, comparable under DC power. Moreover, mechanically damaged TENG‐SDEA displays self‐healing efficiency over 90% 10 cycles. The TENG ensures using TENG‐SDEAs extraocular‐muscle‐like actuator oriented motion ability integrated several constructed. Additionally, directly used flexible capacitive sensor real‐time monitoring patient's muscle movement. Accordingly, medical aid system conjunction manufactured help suffering from ONP physical rehabilitation treatment.

Language: Английский

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Implantable, Biodegradable, and Wireless Triboelectric Devices for Cancer Therapy through Disrupting Microtubule and Actins Dynamics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: July 1, 2023

Electric-field-based stimulation is emerging as a new cancer therapeutic modality through interfering with cell mitosis. To address its limitations of complicated wire connections, bulky devices, and coarse spatial resolution, an improved alternative method proposed for wirelessly delivering electrical into tumor tissues designing implantable, biodegradable, controlled triboelectric nanogenerator (ET-TENG). With the excitation ultrasound (US) to ET-TENG, implanted ET-TENG can generate alternating current voltage concurrently release loaded anti-mitotic drugs tissues, which synergistically disrupts assembly microtubules filament actins, induces cycle arrest, finally enhances death. assistance US, device be completely degraded after therapy, getting free secondary surgical extraction. The not only work around those unresectable tumors, but also provides application wireless electric field in therapy.

Language: Английский

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A New Single‐Electrode Generator for Water Droplet Energy Harvesting with A 3 mA Current Output

Advanced Energy Materials, Journal Year: 2023, Volume and Issue: 14(5)

Published: Dec. 10, 2023

Abstract Triboelectric nanogenerators (TENGs) based on water droplets can harvest kinetic energy using triboelectrification and electrostatic induction mechanisms. However, the development of traditional liquid–solid TENGs (L–S TENGs) is severely limited due to their low‐performance output high device encapsulation requirements for preparation technology. In this work, a single‐electrode mode droplet‐based TENG (D‐TENG) devised effectively by optimizing interface contact behavior droplets, increasing short‐circuit current ( I SC ) one drop from microamperes milliamperes levels. D‐TENG configuration, electrode positioned above dielectric rather than at bottom, allowing efficient utilization generated friction charges reducing dissipation these charges, thereby enhancing performance TENG. The influencing factors operational mechanisms are studied obtain optimized working conditions improve its performance. Under optimal conditions, saturate charge PTFE surface with only 8 achieving an up 3.51 mA voltage V O 298.27 V. This work provides convenient method efficiently harvesting interfacial control.

Language: Английский

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4D printed shape memory metamaterials with sensing capability derived from the origami concept

Nano Energy, Journal Year: 2023, Volume and Issue: 115, P. 108697 - 108697

Published: July 13, 2023

Language: Английский

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Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(3), P. 365 - 383

Published: Jan. 1, 2024

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding supporting future drug delivery system development.

Language: Английский

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