Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(31)
Published: April 14, 2023
Abstract
Hollow
structured
materials
with
easily
modifiable
surfaces
and
enclosed
interior
spaces
have
emerged
as
the
most
promising
candidates
in
drug
delivery
systems
(DDS).
With
various
functional
components
inspiring
cavities
for
creative
reinvention,
response
regulation
of
external
internal
microenvironment
hollow
structures
enable
their
ideal
capabilities
by
improving
aggregation
targeted
sites
maintaining
plasma
concentrations
at
optimal
therapeutic
ranges.
This
review
begins
an
in‐depth
explanation
interactions
release
mechanisms
structure‐based
DDS,
including
diffusion,
assembly,
solvent
activation,
chemical
control,
all
which
are
great
significance
design
smart
carriers.
Next,
recent
advances
microenvironment‐responsive
introduced,
based
on
signals
field
assists.
Focusing
unique
view
intra‐carrier
variability,
strategies
regulating
environment
then
highlighted,
pH
regulation,
temperature
mechanical
force
regulation.
Finally,
this
discusses
possible
challenges
prospects
structure‐based,
particularly
multishelled
intelligence‐responsive
platforms,
providing
valuable
development
next
generation
responsive
DDS.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Cancer
is
one
of
the
leading
causes
death
worldwide,
posing
a
significant
threat
to
human
health.
Although
immunotherapy
has
shown
promise
in
cancer
treatment,
its
efficacy
often
compromised
by
tumor
immune
evasion,
which
hinders
treatment
outcomes.
Therefore,
combining
with
other
therapeutic
approaches
enhance
effectiveness
become
an
increasingly
accepted
strategy
clinical
practice.
In
response
this
need,
nanotechnology‐based
platform,
NanoTrackThera
(NTT),
enables
both
combination
therapy
and
real‐time
diagnosis,
developed.
Using
nonsmall
cell
lung
(NSCLC)
as
model,
NTT
platform
integrates
photothermal
(PTT)
activity
natural
killer
(NK)
cells,
employ
checkpoint
inhibitors,
leverage
heat
generation
from
self‐assembled
nanoparticles
under
near‐infrared
(NIR)
irradiation
directly
kill
cells.
Simultaneously,
nanoplatform
incorporates
dual
detection
capabilities
through
fluorescence
imaging
photoacoustic
imaging.
With
these
multimodal
techniques,
can
achieve
real‐time,
situ,
tracking
biomarker
changes
during
providing
precise
feedback
on
combined
therapy.
The
significantly
enhances
while
enabling
monitoring
dynamic
key
biomarkers,
solution
for
personalized
adaptive
precision
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Photodynamic
therapy
(PDT)
holds
promise
as
a
cancer
treatment
modality
due
to
its
potential
for
enhanced
precision
and
safety.
To
enhance
deep
tissue
penetration
minimize
adsorption
phototoxicity,
developing
photosensitizers
activated
by
second
near-infrared
window
(NIR-II)
light
shows
significant
potential.
However,
the
efficacy
of
PDT
is
often
impeded
tumor
microenvironment
hypoxia,
primarily
caused
irregular
vasculature.
Fortunately,
stimulator
interferon
genes
(STING)
pathway,
known
immune
activation,
has
been
linked
vasculature
normalization.
In
this
study,
we
developed
nanoplatform
(Fe-THBQ/SR)
loading
STING
agonist
(SR-717)
into
an
iron-tetrahydroxy-1,4-benzoquinone
(Fe-THBQ)
metal–organic
framework.
Fe-THBQ
was
proven
be
effective
NIR-II
photosensitizer,
generating
numerous
reactive
oxygen
species
(ROS)
under
1064
nm
laser
irradiation.
These
ROS
downregulated
heat
shock
protein
expression,
consequently
promoting
mild-photothermal
(mild-PTT),
facilitated
ferroptosis
depleting
glutathione
(GSH)/glutathione
peroxidase
4.
Moreover,
Fe-THBQ/SR
released
SR-717
upon
GSH
stimulation,
synergizing
with
ROS-mediated
double-stranded
DNA
leakage
activation.
This
process
contributed
normalization
hypoxia
alleviation,
thereby
enhancing
efficacy.
Overall,
presented
versatile
single-laser-triggered
mild-PTT
simultaneously
coupled
it
activation
form
reinforcing
cycle.
synergistic
enhancements
increased
immunogenicity
cells,
remodeled
immunosuppressive
microenvironment,
T
lymphocyte
infiltration,
improved
therapeutic
outcomes.
Nanoscale Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Composite
nanozymes
are
composed
of
enzymes
with
similar
or
different
catalytic
capabilities
and
have
higher
activity
than
a
single
enzyme.
In
recent
years,
composite
emerged
as
novel
nanomaterial
platforms
for
multiple
applications
in
various
research
fields,
where
they
used
to
produce
oxygen,
consume
glutathione,
toxic
reactive
oxygen
species
(ROS)
cancer
therapy.
The
therapeutic
approach
using
is
known
chemo-dynamic
therapy
(CDT).
Some
also
show
special
photothermal
conversion
effects,
enabling
them
be
combined
pioneering
treatments,
such
photodynamic
(PDT),
(PTT)
sonodynamic
(SDT),
enhance
the
anti-cancer
effects.
this
study,
classification
performances
reviewed,
along
their
advantages
synthesis
methods.
Furthermore,
treatment
cancers
emphasized,
prospective
challenges
future
discussed.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(31)
Published: April 14, 2023
Abstract
Hollow
structured
materials
with
easily
modifiable
surfaces
and
enclosed
interior
spaces
have
emerged
as
the
most
promising
candidates
in
drug
delivery
systems
(DDS).
With
various
functional
components
inspiring
cavities
for
creative
reinvention,
response
regulation
of
external
internal
microenvironment
hollow
structures
enable
their
ideal
capabilities
by
improving
aggregation
targeted
sites
maintaining
plasma
concentrations
at
optimal
therapeutic
ranges.
This
review
begins
an
in‐depth
explanation
interactions
release
mechanisms
structure‐based
DDS,
including
diffusion,
assembly,
solvent
activation,
chemical
control,
all
which
are
great
significance
design
smart
carriers.
Next,
recent
advances
microenvironment‐responsive
introduced,
based
on
signals
field
assists.
Focusing
unique
view
intra‐carrier
variability,
strategies
regulating
environment
then
highlighted,
pH
regulation,
temperature
mechanical
force
regulation.
Finally,
this
discusses
possible
challenges
prospects
structure‐based,
particularly
multishelled
intelligence‐responsive
platforms,
providing
valuable
development
next
generation
responsive
DDS.
