Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 94 - 114

Published: Aug. 7, 2023

Immunogenic cell death (ICD) is a unique mode of death, which can release immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens to trigger long-term protective antitumor immune responses. Thus, amplifying "eat me signal" during tumor ICD cascade critical for cancer immunotherapy. Some therapies (radiotherapy, photodynamic therapy (PDT), photothermal (PTT), etc.) inducers (chemotherapeutic agents, have enabled initiate and/or facilitate activate Recently, nanostructure-based drug delivery systems been synthesized inducing through combining treatment chemotherapeutic photosensitizers PDT, transformation agents PTT, radiosensitizers radiotherapy, etc., loaded at an appropriate dosage in the designated place time, contributing higher efficiency lower toxicity. Also, immunotherapeutic combination with produce synergetic effects, thus potentiating Overall, our review outlines emerging inducers, nanostructure loading diverse evoke chemoradiotherapy, PTT or agents. Moreover, we discuss prospects challenges harnessing induction-based immunotherapy, highlight significance multidisciplinary interprofessional collaboration promote optimal translation this strategy.

Language: Английский

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Dual-targeting nanozyme combined with aPD-L1-based immunotherapy for combating cancer recurrence and metastasis

Materials Today, Journal Year: 2024, Volume and Issue: 73, P. 79 - 95

Published: Feb. 12, 2024

Language: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444

Published: Jan. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Language: Английский

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Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101512 - 101512

Published: April 18, 2024

Our previous work developed acoustic response bacteria, which enable the precise tuning of transgene expression through ultrasound. However, it is still difficult to visualize these bacteria in order guide sound wave precisely irradiate them. Here, we develop ultrasound-visible engineered and chemically modify them with doxorubicin (DOX) on their surfaces. These (Ec@DIG-GVs) can produce gas vesicles (GVs), providing a real-time imaging for remote hyperthermia high-intensity focused ultrasound (hHIFU) induce interferon (IFN)-γ gene. The production IFN-γ kill tumor cells, macrophage polarization from M2 M1 phenotype, promote maturation dendritic cells. DOX be released acidic microenvironment, resulting immunogenic cell death concurrent effects activate tumor-specific T response, producing synergistic anti-tumor efficacy. study provides promising strategy bacteria-mediated chemo-immunotherapy.

Language: Английский

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Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641

Published: April 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Language: Английский

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Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

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Electrosprayed core–shell microspheres co-deliver fibronectin and resveratrol for combined treatment of acute lung injury

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 686, P. 498 - 508

Published: Jan. 31, 2025

Language: Английский

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Cancer Immunotherapy Based on Cell Membrane‐Coated Nanocomposites Augmenting cGAS/STING Activation by Efferocytosis Blockade

Small, Journal Year: 2023, Volume and Issue: 19(43)

Published: June 28, 2023

Innate immunity triggered by the cGAS/STING pathway has potential to improve cancer immunotherapy. Previously, authors reported that double-stranded DNA (dsDNA) released dying tumor cells can trigger pathway. However, owing efferocytosis, are engulfed and cleared before damaged dsDNA is released; hence, immunologic tolerance immune escape occur. Herein, a cancer-cell-membrane biomimetic nanocomposites exhibit tumor-immunotherapeutic effects synthesized augmenting suppressing efferocytosis. Once internalized cells, combined chemo/chemodynamic therapy would be triggered, which damages their nuclear mitochondrial DNA. Furthermore, releasing Annexin A5 protein could inhibit efferocytosis effect promote immunostimulatory secondary necrosis preventing phosphatidylserine exposure, resulting in burst release of dsDNA. These fragments, as molecular patterns immunogenic damage, from activate pathway, enhance cross-presentation inside dendritic M1-polarization tumor-associated macrophages. In vivo experiments suggest proposed nanocomposite recruit cytotoxic T-cells facilitate long-term immunological memory. Moreover, when with immune-checkpoint blockades, it augment response. Therefore, this novel promising strategy for generating adaptive antitumor responses.

Language: Английский

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Redox‐Responsive Dendrimer Nanogels Enable Ultrasound‐Enhanced Chemoimmunotherapy of Pancreatic Cancer via Endoplasmic Reticulum Stress Amplification and Macrophage Polarization

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 23, 2023

Developing a multifunctional nanoplatform to achieve efficient theranostics of tumors through multi-pronged strategies remains be challenging. Here, the design intelligent redox-responsive generation 3 (G3) poly(amidoamine) dendrimer nanogels (NGs) loaded with gold nanoparticles (Au NPs) and chemotherapeutic drug toyocamycin (Au/Toy@G3 NGs) for ultrasound-enhanced cancer is showcased. The constructed hybrid NGs size 193 nm possess good colloidal stability under physiological conditions, can dissociated release Au NPs Toy in reductive glutathione-rich tumor microenvironment (TME). released promote apoptosis cells endoplasmic reticulum stress amplification cause immunogenic cell death maturate dendritic cells. induce conversion tumor-associated macrophages from M2-type antitumor M1-type remodulate immunosuppressive TME. Combined antibody-mediated immune checkpoint blockade, effective chemoimmunotherapy pancreatic mouse model realized, effect further ultrasound enhanced due sonoporation-improved permeability NGs. developed Au/Toy@G3 also enable Au-mediated computed tomography imaging tumors. responsive dendrimeric tackle strategy targeting both cells, which hold promising potential clinical translations.

Language: Английский

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Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

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