Mechanically‐Compliant Bioelectronic Interfaces through Fatigue‐Resistant Conducting Polymer Hydrogel Coating

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: June 29, 2023

Because of their distinct electrochemical and mechanical properties, conducting polymer hydrogels have been widely exploited as soft, wet, coatings for conventional metallic electrodes, providing mechanically compliant interfaces mitigating foreign body responses. However, the long-term viability these hydrogel is hindered by concerns regarding fatigue crack propagation and/or delamination caused repetitive volumetric expansion/shrinkage during electrical interfacing. This study reports a general yet reliable approach to achieving fatigue-resistant coating on bioelectrodes engineering nanocrystalline domains at interface between substrates. It demonstrates efficacy this robust, biocompatible, in cardiac pacing, showcasing its ability effectively reduce pacing threshold voltage enhance reliability electric stimulation. findings highlight potential promising design fabrication strategy next generation seamless bioelectronic interfaces.

Language: Английский

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3D Printed Implantable Hydrogel Bioelectronics for Electrophysiological Monitoring and Electrical Modulation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(21)

Published: Dec. 21, 2023

Abstract Electronic devices based on conducting polymer hydrogels have emerged as one of the most promising implantable bioelectronics for electrophysiological monitoring and diagnosis a wide spectrum diseases, in light their distinct conductivity biocompatibility. However, hydrogels‐based are routinely fabricated through conventional techniques, which challenged by its intrinsic poor processability polymers, well essentially fragile biointerface, thus hampering rapid innovation application advanced bioelectronics. Here, 3D printable poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is reported, featuring superior printability direct ink writing (DIW), tissue‐like mechanical compliance (Young's modulus 650 kPa), instant tough bioadhesion (interfacial toughness 200 J m −2 shear strength 120 highly‐tunable electrical properties, long‐term vitro vivo structural electrochemical robustness. Electro‐physiological studies rat heart models with normal or arrhythmic conditions highlight capabilities establishing conformal biointerface dynamic organs, allowing high‐precision spatiotemporary epicardial monitoring, modulation acute myocardial infarction (MI) model. These advances provide strategy to improve tissue‐electronics interfacing, could serve basis next generation toward healthcare medical therapies.

Language: Английский

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Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning‐Facilitated Human‐Interactive Sensing

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: March 29, 2024

Wearable epidermic electronics assembled from conductive hydrogels are attracting various research attention for their seamless integration with human body conformally real-time health monitoring, clinical diagnostics and medical treatment, human-interactive sensing. Nevertheless, it remains a tremendous challenge to simultaneously achieve bioadhesive remarkable self-adhesiveness, reliable ultraviolet (UV) protection ability, admirable sensing performance high-fidelity epidermal electrophysiological signals along timely photothermal therapeutic performances after diagnostic sensing, as well efficient antibacterial activity hemostatic effect potential therapy. Herein, hydrogel-based sensor, featuring superior self-adhesiveness excellent UV-protection performance, is developed by dexterously assembling conducting MXene nanosheets network biological hydrogel polymer stably attaching onto skin high-quality recording of high signal-to-noise ratios (SNR) low interfacial impedance intelligent diagnosis smart human-machine interface. Moreover, sign language gesture recognition platform based on collected electromyogram (EMG) designed hassle-free communication hearing-impaired people the help advanced machine learning algorithms. Meanwhile, possesses capability, biocompatibility, effective hemostasis properties promising bacterial-infected wound bleeding.

Language: Английский

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Design of Highly Conductive, Intrinsically Stretchable, and 3D Printable PEDOT:PSS Hydrogels via PSS-Chain Engineering for Bioelectronics

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 35(15), P. 5936 - 5944

Published: July 25, 2023

Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)-based hydrogels have emerged as ideal interfacing materials for bioelectronics because of their intriguing electrical, mechanical, and biological properties. However, the development high-performance PEDOT:PSS-based simultaneously achieving high conductivity, robust mechanical properties, accessibility advanced manufacturing technologies remains a critical challenge further advancing such toward practical applications. Herein, we develop highly conductive, intrinsically soft, tough yet stretchable hydrogel via simple PSS-chain engineering strategy introducing thermally cross-linkable N-(hydroxymethyl)acrylamide segments. The resultant PEDOT:PSS exhibits electrical conductivity (1850 S m–1), stretchability (>50%), low Young's modulus (4 MPa), superior toughness (400 kJ m–3), satisfying multiple property requirements bioelectronic Based on this material, novel ink with 3D printability direct writing printing, enabling us to facilely fabricate devices like soft skin electrodes comparable commercial products multi-material printing.

Language: Английский

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Design of Fatigue‐Resistant Hydrogels

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 4, 2024

Abstract Hydrogels are made tough to resist crack propagation. However, for seamless integration into devices and machines, it necessitates robustness against cyclic loads. Central this objective is enhancing fatigue resistance, an indispensable attribute facilitating the optimal performance of hydrogels within a multitude biological contexts, spanning various plant animal tissues, as well diverse biomedical engineering areas. In review, recent research concerning behavior hydrogels, presenting comprehensive consolidation inherent mechanisms that underpin strategies aimed at fortifying summarized. A critical facet in architectural blueprint fatigue‐resistant emphasized, involving imposition spatial constraints upon main chains tips, thereby effectuating protracted delay their fracture initiation during prolonged loading. The multiscale encompassing networks, interactions, media, structures stands pivotal factor design hydrogels. It hoped review will considerably propel pragmatic deployment across array applications, thus catalyzing advancements multiple fields.

Language: Английский

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Connective tissue inspired elastomer-based hydrogel for artificial skin via radiation-indued penetrating polymerization

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 20, 2024

Abstract Robust hydrogels offer a candidate for artificial skin of bionic robots, yet few have comprehensive performance comparable to real human skin. Here, we present general method convert traditional elastomers into tough via unique radiation-induced penetrating polymerization method. The hydrogel is composed the original hydrophobic crosslinking network from and grafted hydrophilic chains, which act as elastic collagen fibers water-rich substances. Therefore, it successfully combines advantages both provides similar Young’s modulus friction coefficients skin, well better compression puncture load capacities than double polyampholyte hydrogels. Additionally, responsive abilities can be introduced during preparation process, granting hybrid shape adaptability. With these properties, fluid flow controller, wound dressing layer many other application scenarios.

Language: Английский

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Wireless Bioelectronics for In Vivo Pressure Monitoring with Mechanically‐Compliant Hydrogel Biointerfaces

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: Feb. 29, 2024

Abstract Recent electronics‐tissues biointefacing technology has offered unprecedented opportunities for long‐term disease diagnosis and treatment. It remains a grand challenge to robustly anchor the pressure sensing bioelectronics onto specific organs, since periodically‐varying stress generated by normal biological processes may pose high risk of interfacial failures. Here, general yet reliable approach is reported achieve robust hydrogel interface between wireless sensor tissues/organs, featuring highly desirable mechanical compliance swelling resistance, despite direct contact with biofluids dynamic conditions. The operated wirelessly through inductive coupling, characterizing minimal hysteresis, fast response times, excellent stability, robustness, thus allowing easy handling eliminating necessity surgical extraction after functional period. operation been demonstrated custom‐made model in vivo intracranial monitoring rats. This be advantageous real‐time post‐operative various inner pressures reconstructive surgery, guaranteeing timely treatment lethal diseases.

Language: Английский

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Neural interfaces: Bridging the brain to the world beyond healthcare

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 14, 2024

Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.

Language: Английский

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Conducting polymer hydrogels based on supramolecular strategies for wearable sensors

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 14, 2024

Abstract Conductive polymer hydrogels (CPHs) are gaining considerable attention in developing wearable electronics due to their unique combination of high conductivity and softness. However, the absence interactions, incompatibility between hydrophobic conductive polymers (CPs) hydrophilic networks gives rise inadequate bonding CPs hydrogel matrices, thereby significantly impairing mechanical electrical properties CPHs constraining utility electronic sensors. Therefore, endow with good performance, it is necessary ensure a stable robust network CPs. Encouragingly, recent research has demonstrated that incorporating supramolecular interactions into enhances interaction, improving overall CPH performance. comprehensive review focusing on (SCPH) for sensing applications currently lacking. This provides summary typical strategies employed development high‐performance elucidates SCPHs closely associated Moreover, discusses fabrication methods classification SCPH sensors, while also exploring latest application scenarios Finally, challenges sensors offers suggestions future advancements.

Language: Английский

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Multifunctional Conductive Hydrogel Interface for Bioelectronic Recording and Stimulation

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 22, 2024

The past few decades have witnessed the rapid advancement and broad applications of flexible bioelectronics, in wearable implantable electronics, brain-computer interfaces, neural science technology, clinical diagnosis, treatment, etc. It is noteworthy that soft elastic conductive hydrogels, owing to their multiple similarities with biological tissues terms mechanics, water-rich, functions, successfully bridged gap between rigid electronics biology. Multifunctional hydrogel emerging as a new generation promising material candidates, authentically established highly compatible reliable, high-quality bioelectronic particularly recording stimulation. This review summarizes basis design principles involved constructing systematically discusses fundamental mechanism unique advantages bioelectrical interfacing surface. Furthermore, an overview state-of-the-art manufacturing strategies for interfaces enhanced biocompatibility integration system presented. finally exemplifies unprecedented impetus toward stimulation, especially integrated systems, concludes perspective expectation bioelectronics biomedical applications.

Language: Английский

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