Periodic Table of Immunomodulatory Elements and Derived Two‐Dimensional Biomaterials DOI Creative Commons
Alireza Rafieerad, Leena Regi Saleth,

Soofia Khanahmadi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Periodic table of chemical elements serves as the foundation material chemistry, impacting human health in many different ways. It contributes to creation, growth, and manipulation functional metallic, ceramic, metalloid, polymeric, carbon‐based materials on near an atomic scale. Recent nanotechnology advancements have revolutionized field biomedical engineering tackle longstanding clinical challenges. The use nano‐biomaterials has gained traction medicine, specifically areas nano‐immunoengineering treat inflammatory infectious diseases. Two‐dimensional (2D) nanomaterials been found possess high bioactive surface area compatibility with mammalian cells at controlled doses. Furthermore, these biomaterials intrinsic immunomodulatory properties, which is crucial for their application immuno‐nanomedicine. While significant progress made understanding bioactivity biocompatibility, exact responses mechanisms are still being explored. Current work outlines innovative “immunomodulatory periodic elements” beyond life, microbial genomics comprehensively reviews role each element designing immunoengineered 2D a group‐wise manner. recapitulates most recent advances nanomaterials, paving way development new mono, hybrid, composite, hetero‐structured biomaterials.

Language: Английский

A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction DOI Creative Commons
Yixin Bian,

Kexin Zhao,

Tingting Hu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 3, 2024

Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe-LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) further modification on bioactive glass scaffold (BGS) obtain versatile platform (BGS@LDH/Se) for comprehensive osteosarcoma management. The uniform dispersion negatively charged SeNPs LDH surface restrains toxicity-inducing aggregation inactivation, thus enhancing superoxide dismutase (SOD) activation anion radical (·O

Language: Английский

Citations

12
PAD4 Inhibitor‐Functionalized Layered Double Hydroxide Nanosheets for Synergistic Sonodynamic Therapy/Immunotherapy Of Tumor Metastasis DOI Creative Commons
Di Zhu, Yu Lu,

Shuqing Yang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 6, 2024

Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356) for synergistic SDT/immunotherapy. Specifically, a‐CoW‐LDH act as sonosensitizer generate abundant reactive oxygen species (ROS) under US irradiation. After loading a‐LDH@356 plus irradiation not only effectively induces ROS generation immunogenic death, but also inhibits elevation citrullinated histone H3 (H3cit) release NETs, enabling enhancement anti‐tumor metastasis effect. Using 4T1 model, it that combining YW3‐56 stimulates an by upregulating proportion immune‐activated cells inducing polarization M1 macrophages, escape downregulating expression PD‐1 on irradiation, which arrests primary progression inhibition rate 69.5% prevents least number lung nodules.

Language: Английский

Citations

10
Copper-based nanomaterials for biomedical applications DOI Creative Commons
Qichen Wei, Yue Pan, Zheng Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149040 - 149040

Published: Jan. 23, 2024

Among metal-based nanomaterials, Copper-based nanomaterials (Cu-BNMs) have become a research hotspot in the biomedical field due to their good biocompatibility and unique properties. However, there are fewer systematic summaries of copper-based especially synthesis Cu-BNMs. As for applications, Cu-BNMs been widely used fields antimicrobial, imaging, therapeutics, showing excellent promising Herein, this review firstly introduces classification various methods synthesizing through both top-down bottom-up types. Then, applications within three tumor therapy classified summarized. Finally, challenges faced application future development c discussed provide basic information illustrations

Language: Английский

Citations

9
PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy DOI Creative Commons
Liang Yin,

Shufang Ning,

Mekhrdod S. Kurboniyon

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.

Language: Английский

Citations

1
Periodic Table of Immunomodulatory Elements and Derived Two‐Dimensional Biomaterials DOI Creative Commons
Alireza Rafieerad, Leena Regi Saleth,

Soofia Khanahmadi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Periodic table of chemical elements serves as the foundation material chemistry, impacting human health in many different ways. It contributes to creation, growth, and manipulation functional metallic, ceramic, metalloid, polymeric, carbon‐based materials on near an atomic scale. Recent nanotechnology advancements have revolutionized field biomedical engineering tackle longstanding clinical challenges. The use nano‐biomaterials has gained traction medicine, specifically areas nano‐immunoengineering treat inflammatory infectious diseases. Two‐dimensional (2D) nanomaterials been found possess high bioactive surface area compatibility with mammalian cells at controlled doses. Furthermore, these biomaterials intrinsic immunomodulatory properties, which is crucial for their application immuno‐nanomedicine. While significant progress made understanding bioactivity biocompatibility, exact responses mechanisms are still being explored. Current work outlines innovative “immunomodulatory periodic elements” beyond life, microbial genomics comprehensively reviews role each element designing immunoengineered 2D a group‐wise manner. recapitulates most recent advances nanomaterials, paving way development new mono, hybrid, composite, hetero‐structured biomaterials.

Language: Английский

Citations

1