RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14131 - 14138
Published: Jan. 1, 2023
A new nano-contrast agent had been designed to respond the pH of microenvironment breast cancer, enabling CEST MRI imaging identify aggressiveness different subtypes cancer.
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)
Published: Oct. 11, 2023
Abstract Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed induce harmonious balanced pyroptosis cuproptosis using “Tai Chi mindset” awaken response for suppressing recurrent tumors. This cleverly material can disrupt antioxidant defense mechanism of tumor cells by inhibiting nuclear factor‐erythroid 2‐related factor 2 (NRF2)‐quinone oxidoreductase 1 (NQO1) signaling pathway. Furthermore, combined with its excellent multienzyme activity, it activates NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis. Meanwhile, be triggered copper ions released from disintegration NPs sensitivity cancer enhanced through depletion endogenous chelators via Michael addition reaction between glutathione (GSH) quinone ligand, oxygen production catalase‐like reaction, starvation‐induced glucose deficiency. More importantly, NPs‐induced promote immunosuppressive microenvironment (TME) remodeling, enhance infiltration into tumor, activate robust systemic immunity. Collectively, this study provides new strategy resist dormancy, recurrence, improve clinical prognosis
Language: Английский
Citations
83
Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)
Published: Feb. 11, 2024
Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified metal‐organic frameworks (MOF). After cellular, dissociates CaO Cu 2+ tumor microenvironment. The exposed further yields hydrogen (H O Ca weakly acidic environment to strengthen ‐based Fenton‐like reaction. Furthermore, combination chemodynamic therapy overload exacerbates ROS storms mitochondrial damage, resulting downregulation intracellular adenosine triphosphate (ATP) levels blocking Cu‐ATPase sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic death suppresses metastasis simultaneously. study presents multivariate model for revolutionizing mitochondria relying continuous retention ions boost cuproptosis/immunotherapy cancer.
Language: Английский
Citations
33
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)
Published: Feb. 23, 2024
Abstract Autophagy, a lysosome‐involved degradation pathway, as self‐protective cellular process, always weakens the efficiency of tumor therapies. Herein, for first time, biodegradable copper (Cu) ions doped layered double hydroxide (Cu‐LDH) nanoparticles are reported cancer immunotherapy via lysosomal rupture‐mediated “Broken Window Effect”. Only injection Cu‐LDH single therapeutic agent achieves various organelles destruction after rupture, well abnormal aggregation Cu in cells cuproptosis and pyroptosis. More importantly, autophagy inhibition caused by rupture improves overload‐mediated pyroptosis blocking lysosome‐mediated bulk leading to good anti‐tumor immune responses ultimately high‐efficiency growth inhibition. This Effect” provides new paradigm enhanced therapy.
Language: Английский
Citations
23
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 212, P. 115411 - 115411
Published: July 19, 2024
Language: Английский
Citations
9
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2447 - 2474
Published: March 18, 2024
The clinical efficacy of current cancer therapies falls short, and there is a pressing demand to integrate new targets with conventional therapies. Autophagy, highly conserved self-degradation process, has received considerable attention as an emerging therapeutic target for cancer. With the rapid development nanomedicine, nanomaterials have been widely utilized in therapy due their unrivaled delivery performance. Hence, considering potential benefits integrating autophagy nanotechnology therapy, we outline latest advances autophagy-based nanotherapeutics. Based on brief background related nanotherapeutics impact tumor progression, feasibility treatment demonstrated. Further, developed modulate are reviewed from perspective cell signaling pathways, including modulation mammalian rapamycin (mTOR) pathway, autophagy-related (ATG) its complex expression, reactive oxygen species (ROS) mitophagy, interference autophagosome-lysosome fusion, inhibition hypoxia-mediated autophagy. In addition, combination which nano-autophagy combined chemotherapy, phototherapy, immunotherapy also described. Finally, prospects challenges efficient envisioned.
Language: Английский
Citations
7
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)
Published: May 25, 2024
Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.
Language: Английский
Citations
7
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969
Published: June 10, 2024
Language: Английский
Citations
7
Nano Today, Journal Year: 2023, Volume and Issue: 52, P. 101981 - 101981
Published: Sept. 6, 2023
Language: Английский
Citations
13
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 26590 - 26603
Published: May 14, 2024
Photodynamic therapy (PDT) based on upconversion nanoparticles (UCNPs) has been widely used in the treatment of a variety tumors. Compared with other therapeutic methods, this advantages high efficiency, strong penetration, and controllable range. PDT kills tumors by generating large amount reactive oxygen species (ROS), which causes oxidative stress tumor. However, killing effect is significantly inhibited tumor's own resistance to ROS. This because can either deplete ROS concentration glutathione (GSH) or stimulate autophagy eliminate ROS-generated damage. Furthermore, tumor also consume through lactic acid metabolic pathway, ultimately hindering progress. To address conundrum, we developed UCNP-based nanocomposite for enhanced reducing resistance. First, Ce6-doped SiO2 encapsulated UCNPs ensure efficient energy transfer between Ce6. Then, biodegradable tetrasulfide bond-bridged mesoporous organosilicon (MON) was coated outer layer load chloroquine (CQ) α-cyano4-hydroxycinnamic (CHCA). Finally, hyaluronic utilized modify nanomaterials realize an active-targeting ability. The obtained final product abbreviated as UCNPs@MON@CQ/CHCA@HA. Under 980 nm laser irradiation, upconverted red light from excited Ce6 produce singlet (1O2), thus achieving PDT. loaded CQ CHCA MON achieved multichannel enhancement Specifically, blocked process cells, uptake cells. In addition, consumed level intracellular GSH. way, these three functions complemented each other, just "three musketeers" punctured multiple angles, both vitro vivo experiments had demonstrated elevated efficacy nanomaterials.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154499 - 154499
Published: Aug. 3, 2024
Language: Английский
Citations
4