Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor DOI Creative Commons

Linlin Huo,

Shiqi Zhu,

Muyao Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Pyroptosis inducer, a powerful anti‐tumor agent that causes obvious programmed cell death and immune stimulation, has been challenged to trigger specific pyroptotic tumor while keeping pyroptosis silence in normal cells. Here, an intelligent inducer is reported acts as reactive oxygen species (ROS) scavenger cells keep silence, serving ROS generator induce dependent on high hydrogen peroxide levels near‐infrared laser irradiation. This switchable activity ensures this precisely kill the with augmented immunogenicity causing minimal damage Moreover, catalase‐like endows overcome limitation of hypoxia generation show significant activation, further initiating response inhibit metastases vivo. study provides valuable insights into design new controllable specifically for precise therapy side effects.

Language: Английский

Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chenliang Zhang, Tingting Huang, Liping Li

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 16, 2024

Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and loss iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress triggering death. Recently, has garnered significant interest tumor research due to its potential as crucial therapeutic strategy against cancer. In this review, we summarized cellular molecular mechanisms relationship other types Additionally, reviewed current drugs or strategies available induce cells, including Cu ionophores, small compounds, nanomedicine. Furthermore, targeted metabolism specific regulatory genes cancer therapy enhance sensitivity cuproptosis. Finally, discussed feasibility targeting overcome chemotherapy immunotherapy resistance suggested future directions. This study that could open new avenues for developing therapy.

Language: Английский

Citations

18
Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition DOI Open Access

Ju‐E Cun,

Ziyun He,

Fan Xi

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Language: Английский

Citations

2
Self‐Sustained Biophotocatalytic Nano‐Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis DOI Creative Commons

Wenshuai Han,

Jiang‐Qiao Ding,

Bo Qiao

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application tumors. To overcome these limitations, a self‐sustained organelle‐mimicking nanoreactor is developed here with programmable DNA switches that enables bio‐chem‐photocatalytic cascade‐driven starvation‐photodynamic synergistic against tumor metastasis. Emulating compartmentalization positional assembly strategies found living cells, this nano‐organelle reactor allows quantitative co‐compartmentalization multiple functional modules designed self‐illuminating chemiexcited PDT system. Within space‐confined nanoreactor, biofuel glucose converted hydrogen peroxide (H 2 O ) which enhances luminol‐based chemiluminescence (CL), consequently driving generation photochemical singlet ( 1 via resonance energy transfer. Meanwhile, hemoglobin functions as synchronized supplier both oxidation PDT, while also exhibiting peroxidase‐like activity produce hydroxyl radicals (·OH). Crucially, keeps switching off normal tissues, on‐demand activation tumors through toehold‐mediated strand displacement. These findings demonstrate self‐sufficient precise striking tumors, promising paradigm managing highly metastatic cancers.

Language: Английский

Citations

2
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

Citations

2
Biodegradable pyroptosis inducer with multienzyme-mimic activity kicks up reactive oxygen species storm for sensitizing immunotherapy DOI
Junrong Wang,

Luying Qiao,

Guo‐Qing Zhu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 438 - 452

Published: May 6, 2024

Language: Английский

Citations

10
Periodic Table of Immunomodulatory Elements and Derived Two‐Dimensional Biomaterials DOI Creative Commons
Alireza Rafieerad, Leena Regi Saleth,

Soofia Khanahmadi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Periodic table of chemical elements serves as the foundation material chemistry, impacting human health in many different ways. It contributes to creation, growth, and manipulation functional metallic, ceramic, metalloid, polymeric, carbon‐based materials on near an atomic scale. Recent nanotechnology advancements have revolutionized field biomedical engineering tackle longstanding clinical challenges. The use nano‐biomaterials has gained traction medicine, specifically areas nano‐immunoengineering treat inflammatory infectious diseases. Two‐dimensional (2D) nanomaterials been found possess high bioactive surface area compatibility with mammalian cells at controlled doses. Furthermore, these biomaterials intrinsic immunomodulatory properties, which is crucial for their application immuno‐nanomedicine. While significant progress made understanding bioactivity biocompatibility, exact responses mechanisms are still being explored. Current work outlines innovative “immunomodulatory periodic elements” beyond life, microbial genomics comprehensively reviews role each element designing immunoengineered 2D a group‐wise manner. recapitulates most recent advances nanomaterials, paving way development new mono, hybrid, composite, hetero‐structured biomaterials.

Language: Английский

Citations

1
Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective DOI
Zifan Pei,

Longxiao Li,

Nailin Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969

Published: June 10, 2024

Language: Английский

Citations

7
Cuproptosis in cancer: biological implications and therapeutic opportunities DOI Creative Commons
Liping Li,

Houfeng Zhou,

Chenliang Zhang

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: June 25, 2024

Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.

Language: Английский

Citations

7
Plasma Membrane Targeted Photodynamic Nanoagonist to Potentiate Immune Checkpoint Blockade Therapy by Initiating Tumor Cell Pyroptosis and Depleting Infiltrating B Cells DOI
Yingtao Zhong,

Ziwen Qiu,

Keyan Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable benefits in the treatment of malignant tumors, but clinical response rates are unsatisfied due to low tumor immunogenicity and abundant immunosuppressive cells. Herein, a plasma membrane targeted photodynamic nanoagonist (designated as PMTPN) is developed potentiate ICB by initiating cell pyroptosis depleting infiltrating B PMTPN composed rationally designed chimeric peptide sequence loaded with Bruton's tyrosine kinase inhibitor (Ibrutinib). Notably, capable sequentially targeting trigger immunogenic cause overwhelming release cytokines, promoting dendritic cells maturation, cytotoxic T lymphocytes (CTLs) activation. Meanwhile, can also deplete reduce secretion interleukin‐10 decrease regulatory enhance CTLs infiltration. Beneficially, synergistic immune modulating characteristics simultaneously eliminate primary distant tumors. This study offers promising strategy elevate immunotherapeutic rate consideration complex factors.

Language: Английский

Citations

0
In Situ Design of Metal‐Phenolic Networks Coated Layered Double Hydroxides S‐Scheme Photothermal Nanoreactor for Highly Efficient CO2 Reduction DOI Open Access

Cui He,

Shun‐Li Li,

Rui Zhou

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Light‐driven conversion of CO 2 to fuel is the most attractive approach achieve global carbon neutrality. However, severe recombination photogenerated carriers and narrow range solar spectrum utilization make its application still challenging. Here, a metal‐phenolic networks (MPNs) coated layered double hydroxide S‐scheme photothermal nanoreactor (CoAl‐LDH @ TA‐Cu‐6 nm) designed. It can efficiently capture infrared light surprising 23‐fold performance improvement over CoAl‐LDH under simulated sunlight illumination. A variety in situ characterizations (in XPS DRIFTS) DFT calculations explore that fascinating comes from efficient charge separation migration catalysts, properties endowed by creatively introduced MPNs nanoscale pseudo‐greenhouse effect brought about ingenious coating structure. This work provides new insights into integration micromorphology electronic state modification (defect heterojunction engineering) broad spectrally responsive photocatalytic design reveals mechanism for synergistically enhancing activity at nano‐, atomic‐, subatomic‐scales, giving golden key address energy crisis environmental challenges.

Language: Английский

Citations

0