Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(47)
Published: Oct. 3, 2024
Abstract
Acute
lung
injury
(ALI)
is
a
severe
complication
in
clinical
settings.
Alert
diagnosis
and
severity
assessment
of
ALI
pivotal
to
ensure
curative
treatment
increase
survival
rates.
However,
the
development
precise
diagnostic
strategy
remains
pending
task.
Here,
leveraging
neutrophil's
inflammation‐homing
physiological
barrier‐navigating
capability,
facile
proposed
for
achieving
targeted
19
F‐MRI
detection
based
on
nanoengineered
neutrophil
internalized
with
perfluorocarbon
nanoemulsion
(Neu@PFC).
The
remodeling
process
poses
negligible
impact
inherent
activation
transmigration
functions.
migratory
behavior
Neu@PFC
toward
pneumonia
confirmed
vivo
using
an
LPS‐induced
murine
model.
Direct
intratracheal
(
i.t
.)
administration
contributes
vast
deposition
within
lung,
allowing
real‐time
visualization
potential
predict
progressive
pneumonia.
Furthermore,
intravenous
i.v
enables
quantitative
extent
due
chemokine‐guided
migration.
This
study
not
only
provides
pathway
diagnose
ALI,
but
also
sheds
light
recruitment
cues
different
tissues
inflammatory
conditions,
which
prerequisite
developing
therapeutic
approaches.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 2, 2024
Abstract
Spatial
and
temporal
precisely
control
of
direction
speed
is
crucial
for
nanomotors
to
enable
complex
operations
applications
in
microsurgery,
drug
delivery,
isolation
biological
targets,
so
on.
Judicious
material
design
involving
Janus
nanoparticles
has
been
popular
over
the
past
decades,
however,
precise
customizable
modulation
structure
with
a
specific
asymmetric
ratio
motion
still
challenging.
In
this
study,
universal
“interface
allocation”
strategy
developed
efficient
controllable
preparation
mesoporous
silica‐coated
upconversion
(Janus
UCNP@mSiO
2
)
tuned
achieve
near‐infrared
(NIR)‐controlled
active
mobility
relieving
vessel
plaque.
Mesoporous
silica
thickness
50
nm
coated
onto
nanoparticles’
surface
an
optimal
coverage
50%
encapsulate
gas
propellant.
Upon
exposure
upconverted
blue
light,
release
nitric
oxide,
facilitating
their
pathologically
improving
atherosclerosis
through
endothelium‐dependent
vasodilation.
Experimental
theoretical
simulation
results
demonstrate
advantages
NIR‐controlled
treatment,
including
enhanced
nanoparticle‐transmittance
rate
(34.83%
85.57%)
excellent
vivo
therapeutic
efficacy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 13, 2024
Abstract
Acute
lung
injury
(ALI)
poses
a
significant
and
escalating
medical
challenge,
where
precise
diagnosis
timely
intervention
hold
utmost
importance
in
halting
its
deterioration.
Nevertheless,
persistent
obstacles
arise
from
the
lack
of
agents
proficient
both
real‐time
efficient
mitigation
ALI.
Here,
biocatalytic
second
near‐infrared
(NIR‐II)
fluorescence‐illuminating
nanoplatform
is
designed
to
simultaneously
facilitate
monitoring
robust
inflammation
alleviation
The
study
first
develops
new
aggregation‐induced
emission
luminogen
with
trifluoromethyl
substitutions,
which
increase
NIR‐II
wavelength
fluorescence
brightness.
molecular
probe
further
integrated
into
hollow
ceria
nanostructures,
cloaked
pre‐activated
macrophage
membranes
for
targeted
intervention.
Upon
inhalation
administration
ALI
mice,
theranostic
nanoagents
leverage
bright
active
inflammation‐tropic
properties
vivo
sensitive
imaging
ALI,
also
facilitates
tracking
nanoagents’
distribution
dynamic
fate
within
pneumonia
milieu.
Concurrently,
catalytic
prowess
nanoplatforms
efficaciously
scavenges
excess
reactive
oxygen
species,
dampens
proinflammatory
cytokines,
promotes
repolarization,
substantially
alleviating
acute
damage.
multifaceted
integrates
bioimaging
nanocatalysis‐mediated
immunoregulation,
offering
versatile
promising
approach
addressing
intricate
challenges
posed
by
diseases.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
372, P. 59 - 68
Published: June 14, 2024
Antitumor
agents
often
lack
effective
penetration
and
accumulation
to
achieve
high
therapeutic
efficacy
in
treating
solid
tumors.
Nanomotor-based
nanomaterials
offer
a
potential
solution
address
this
obstacle.
Among
them,
nitric
oxide
(NO)
based
nanomotors
have
garnered
attention
for
their
applications
nanomedicine.
However,
there
widespread
clinical
adoption
has
been
hindered
by
complex
preparation
processes.
To
limitation,
we
developed
NO-driven
nanomotor
utilizing
convenient
scalable
nanogel
procedure.
These
nanomotors,
loaded
with
the
fluorescent
probe
/
sonosensitizer
chlorin
e6
(Ce6),
were
specifically
engineered
sonodynamic
therapy.
Through
comprehensive
vitro
investigations
using
both
2D
3D
cell
models,
as
well
vivo
analysis
of
Ce6
signal
distribution
tumor
observed
that
self-propulsion
these
significantly
enhances
cellular
uptake
penetration,
particularly
This
phenomenon
enables
efficient
access
challenging
regions
and,
some
cases,
results
complete
coverage.
Notably,
our
demonstrated
long-term
biosafety.
study
presents
an
approach
enhancing
drug
improving
treatment,
relevance
future
applications.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(32), P. 21221 - 21235
Published: July 30, 2024
The
mechanical
properties
of
nanoparticles
play
a
crucial
role
in
regulating
nanobiointeractions,
influencing
processes
such
as
blood
circulation,
tumor
accumulation/penetration,
and
internalization
into
cancer
cells.
Consequently,
they
have
significant
impact
on
drug
delivery
therapeutic
efficacy.
However,
it
remains
unclear
whether
how
macrophages
alter
their
biological
function
response
to
nanoparticle
elasticity.
Here,
we
report
the
nano-mechanical
effects
resulting
from
interactions
between
elastic
silica
(SNs)
macrophages.
SNs
with
variational
elasticity
Young's
moduli
ranging
81
837
MPa
were
synthesized,
was
demonstrated
that
M2
[tumor-associated
(TAMs)]
could
be
repolarized
M1
by
soft
SNs.
Additionally,
our
findings
revealed
cell
endocytosis,
membrane
tension,
curvature
protein
Baiap2,
cytoskeleton
all
influenced
Moreover,
mechanically
sensitive
Piezo1
activated,
leading
calcium
ion
influx,
activation
NF-κB
pathway,
initiation
an
inflammatory
response.
In
vivo
experiments
softest
enhanced
penetration
accumulation
TAMs
intratumoral
hypoxic
regions,
ultimately
inhibition
growth.
Taken
together,
this
study
has
established
cellular
feedback
mechanism
elasticity,
which
induces
plasma
deformation
subsequent
mechanosensitive
signals.
This
provides
distinctive
"nano-mechanical
immunoengineering"
strategy
for
reprogramming
enhance
immunotherapy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Excessive
intracellular
iron
accumulation
can
induce
mitochondrial
dysfunction,
leading
to
chondrocyte
ferroptosis,
a
key
contributor
cartilage
damage
in
osteoarthritis
(OA).
Here,
micelle-microfluidic
hydrogel
microspheres,
featuring
keto-enol-thiol
bridged
nano-sized
secondary
structures
that
disintegrate
within
the
peroxidative
environment
reveal
β-diketone
groups
with
metal
chelation
capabilities,
are
utilized
for
situ
removal
of
reactive
iron,
thereby
facilitating
repair
through
restoration
homeostasis.
The
relevant
experiments
demonstrate
microspheres
reduce
influx
by
downregulating
transferrin
receptor
(TfR1)
expression
and
decrease
uptake
upregulating
outer
membrane
iron-sulfur
cluster
protein
(CISD1),
thus
restoring
Furthermore,
antioxidant
properties
ketone-thioether
segments
synergistically
mitigate
phospholipid
peroxidation
via
Nrf2/SLC7A11/GPX4
axis,
inhibiting
ferroptosis
slowing
OA
progression.
In
summary,
this
system
sustainably
chelates
coordination
exhibits
great
potential
minimally
invasive
treatment
other
ferroptosis-mediated
diseases.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 22, 2025
Microcapsules
composed
of
synthetic
polymeric
matrices
have
attracted
considerable
attention
in
delivering
oral
probiotics.
However,
existing
microcapsules
demonstrate
inadequate
acid
resistance
and
adaptability,
as
well
deficiency
the
inflamed
colon-specificity
uncontrolled
release
probiotics
therein.
Herein,
a
DNA
microcapsule
is
prepared
probiotic-transporting
micromotor
through
photo-crosslinking
hyaluronic
methacrylate
acrydite-modified
A-/C-rich
oligomers
within
microfludically
generated
droplets
presence
nitric
oxide-cleavable
crosslinker
gas
donor
manganese
carbonyl
(MnCO).
As
traverse
stomach,
duodenum,
ultimately
colon,
formation
dissociation
A-motif
i-motif
structures
instigate
reversible
shrinking-swelling
transition
to
preserve
probiotic
viability.
Subsequently,
exhibit
chemotaxis
towards
colon
site,
driven
by
gas-generating
reaction
between
MnCO
elevated
reactive
oxygen
species.
Following
disintegration
microcapsules,
triggered
endogenous
oxide,
are
released
reshape
dysbiosis
intestinal
microflora.
This
advanced
delivery
system
offers
significant
promise
for
effective
clinical
management
inflammatory
bowel
disease.
