Ultrasound-Mediated Piezoelectric Microneedles Regulating Macrophage Polarization and Remodeling Pathological Microenvironment for Lymphedema Improvement DOI
Xueqian Wang,

Chengyao Han,

Jingyi Xia

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 19(1), P. 1447 - 1462

Published: Dec. 30, 2024

Lymphedema, a severe and complex inflammatory disease caused by lymphatic system insufficiency impeded drainage that causes an enormous physical psychological burden on patients may even lead to death, has long been challenging issue in the medical field. Clinically, conventional approaches including surgical treatment conservative have employed for lymphedema therapy, but their curative effect is still unsatisfactory because of high operational difficulty, cost, long-term reliance. In this study, novel kind piezoelectric microneedle driven ultrasound (US) proposed regulate macrophage polarization remodel pathological microenvironment noninvasive manner, thereby promoting regeneration improving lymphedema. US-mediated microneedles can significantly enhance anti-inflammatory M2-type macrophages while suppressing pro-inflammatory M1-type vitro. Enhancements M2 trigger increased secretion factors (e.g., IL-4, IL-10, Arg-1) promote remodeling immune rebalancing. mouse-tail model, higher proportion marker CD206 observed accompanied normal lymphangiogenesis subsiding following with US stimulation treatment. Additionally, based RNA sequencing mechanistic investigation, it was revealed activate signaling pathways related responses improve function, consequently alleviating Collectively, study provides new strategy therapy drug-free manner as well potent tool manipulate other immunological diseases.

Language: Английский

Zwitterionic Poly(ethylene glycol) Nanoparticles Minimize Protein Adsorption and Immunogenicity for Improved Biological Fate DOI
Yuan Tian,

Huiyuan Lv,

Yi Ju

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.

Language: Английский

Citations

2
Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development DOI
Yanlin Jiang, Yu Cao, Yiqun Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

Citations

1
Nano-strategies for Targeting Tumor-Associated Macrophages in Cancer immunotherapy DOI Creative Commons
Qian Li, Jingwei Xu, Rong Hua

et al.

Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(7), P. 2261 - 2274

Published: March 31, 2025

Tumor-associated macrophages (TAMs) are one type of the most abundant immune cells within tumor, resulting in immunosuppresive tumor microenvironment and resistance to immunotherapy. Thus, targeting TAMs is a promising therapeutic strategy for boosting cancer This study provides an overview current strategies TAMs, which focus on blocking recruitment by tumors, regulating polarization directly eliminating using various nanodrugs, especially with new categorization based specific signaling pathways, such as NF-κB, HIF-1α, ROS, STAT, JNK, PI3K, Notch involved their regulatory mechanism. The latest developments nanodrugs modulating these pathways discussed determining role microenvironment. Despite challenges clinical translation complexity nanodrug synthesis, potential enhancing effectiveness immunotherapy worthy expecting.

Language: Английский

Citations

0
Intracellular and extracellular stiffness regulation in osteosarcoma: Overcoming mechano-immune checkpoints to enhance anti-osteosarcoma immunity DOI

Linbang Wang,

Ziyu Wang, Xuan Fu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162930 - 162930

Published: April 1, 2025

Citations

0
Advances in Biomaterial Mechanical Properties to Regulate Macrophage Polarization DOI Open Access

恒基 贾

Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 792 - 799

Published: Jan. 1, 2025

Language: Английский

Citations

0
Progress in the mechanical properties of nanoparticles for tumor-targeting delivery DOI
Zheng Li, Chen Xiao, Xiangliang Yang

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Three distinct themes on the advancements in mechanical properties of cancer nanomedicine.

Language: Английский

Citations

0
Ultrasound-Mediated Piezoelectric Microneedles Regulating Macrophage Polarization and Remodeling Pathological Microenvironment for Lymphedema Improvement DOI
Xueqian Wang,

Chengyao Han,

Jingyi Xia

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 19(1), P. 1447 - 1462

Published: Dec. 30, 2024

Lymphedema, a severe and complex inflammatory disease caused by lymphatic system insufficiency impeded drainage that causes an enormous physical psychological burden on patients may even lead to death, has long been challenging issue in the medical field. Clinically, conventional approaches including surgical treatment conservative have employed for lymphedema therapy, but their curative effect is still unsatisfactory because of high operational difficulty, cost, long-term reliance. In this study, novel kind piezoelectric microneedle driven ultrasound (US) proposed regulate macrophage polarization remodel pathological microenvironment noninvasive manner, thereby promoting regeneration improving lymphedema. US-mediated microneedles can significantly enhance anti-inflammatory M2-type macrophages while suppressing pro-inflammatory M1-type vitro. Enhancements M2 trigger increased secretion factors (e.g., IL-4, IL-10, Arg-1) promote remodeling immune rebalancing. mouse-tail model, higher proportion marker CD206 observed accompanied normal lymphangiogenesis subsiding following with US stimulation treatment. Additionally, based RNA sequencing mechanistic investigation, it was revealed activate signaling pathways related responses improve function, consequently alleviating Collectively, study provides new strategy therapy drug-free manner as well potent tool manipulate other immunological diseases.

Language: Английский

Citations

2