Small,
Journal Year:
2023,
Volume and Issue:
19(44)
Published: July 1, 2023
Abstract
Wound
healing,
known
as
a
fundamental
healthcare
issue
worldwide,
has
been
attracting
great
attention
from
researchers.
Here,
novel
bioactive
gellan
gum
microfibers
loaded
with
antibacterial
peptides
(ABPs)
and
vascular
endothelial
growth
factor
(VEGF)
are
proposed
for
wound
healing
by
using
microfluidic
spinning.
Benefitting
the
high
controllability
of
microfluidics,
uniform
morphologies
obtained.
The
ABPs
demonstrated
to
effectively
act
on
bacteria
at
site,
reducing
risk
bacterial
infection.
Besides,
sustained
release
VEGF
helps
accelerate
angiogenesis
further
promote
healing.
practical
value
woven
is
via
animal
experiments,
where
process
greatly
facilitated
because
excellent
circulation
air
nutritious
substances.
Featured
above
properties,
it
believed
that
would
have
remarkable
effect
in
field
biomedical
application,
especially
promoting
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(19)
Published: Feb. 22, 2023
Diabetic
wound
(DW)
therapy
is
currently
a
big
challenge
in
medicine
and
strategies
to
enhance
neurogenesis
angiogenesis
have
appeared
be
promising
direction.
However,
the
current
treatments
failed
coordinate
simultaneously,
leading
an
increased
disability
rate
caused
by
DWs.
Herein,
whole-course-repair
system
introduced
hydrogel
concurrently
achieve
mutually
supportive
cycle
of
neurogenesis-angiogenesis
under
favorable
immune-microenvironment.
This
can
first
one-step
packaged
syringe
for
later
situ
local
injections
cover
wounds
long-termly
accelerated
healing
via
synergistic
effect
magnesium
ions
(Mg2+
)
engineered
small
extracellular
vesicles
(sEVs).
The
self-healing
bio-adhesive
properties
make
it
ideal
physical
barrier
At
inflammation
stage,
formulation
recruit
bone
marrow-derived
mesenchymal
stem
cells
sites
stimulate
them
toward
neurogenic
differentiation,
while
providing
immune
microenvironment
macrophage
reprogramming.
proliferation
stage
repair,
robust
occurs
newly
differentiated
neural
released
Mg2+
,
allowing
regenerative
take
place
at
site.
provides
novel
platform
combined
DW
therapy.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 20, 2024
Abstract
Robust
hydrogels
offer
a
candidate
for
artificial
skin
of
bionic
robots,
yet
few
have
comprehensive
performance
comparable
to
real
human
skin.
Here,
we
present
general
method
convert
traditional
elastomers
into
tough
via
unique
radiation-induced
penetrating
polymerization
method.
The
hydrogel
is
composed
the
original
hydrophobic
crosslinking
network
from
and
grafted
hydrophilic
chains,
which
act
as
elastic
collagen
fibers
water-rich
substances.
Therefore,
it
successfully
combines
advantages
both
provides
similar
Young’s
modulus
friction
coefficients
skin,
well
better
compression
puncture
load
capacities
than
double
polyampholyte
hydrogels.
Additionally,
responsive
abilities
can
be
introduced
during
preparation
process,
granting
hybrid
shape
adaptability.
With
these
properties,
fluid
flow
controller,
wound
dressing
layer
many
other
application
scenarios.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 11, 2024
Abstract
The
continuously
growing
utilization
of
wound
healing
materials
and
skin
bioelectronics
urges
the
development
flexible
hydrogels
for
personal
therapy
health
management.
Versatile
conductive
prepared
from
natural
biomass
are
ideal
candidates
as
one
promising
solutions
chronic
Here,
study
proposes
a
kind
robust
(strain:
1560.8%),
adhesive,
self‐healing,
injectable,
antibacterial
(sterilization
rate:
99%),
near‐infrared
(NIR)
photothermal
responsive,
biocompatible,
hydrogel
(CPPFe@TA)
composed
carboxymethyl
cellulose
tannic
acid/iron
ion
complex
(TA@Fe
3+
),
featuring
rapid
self‐assembly
tunable
crosslinking
time.
TA@Fe
facilitated
self‐catalysis
polymerization
reaction,
time
could
be
controlled
by
adjusting
Fe
concentration.
Under
NIR
irradiation,
exhibited
remarkable
performance.
In
full‐thickness
defect
repair
experiment
on
mice,
dressing
significantly
enhanced
healing.
After
14
days,
rate
(95.49%)
CPPFe@TA3
+
treatment
greatly
exceeded
that
commercial
dressings.
Meanwhile,
has
good
electrical
conductivity
thermo‐responsiveness,
making
them
in
physiological
signal
monitoring
rehabilitation
exercise
This
work
therefore
offers
strategy
developing
versatile
biomass‐based
hydrogels,
which
is
expected
to
applicable
integrated
regenerative
bioelectronics.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(43)
Published: June 25, 2023
Abstract
In
diabetic
wound
healing,
M1
macrophage
accumulation
and
elevated
inflammation
are
prevalent
issues.
Intelligent
delivery
systems
that
can
sustainably
release
antioxidizing
anti‐inflammatory
ingredients
expected
for
effective
healing.
Herein,
a
novel
glycyrrhetinic
acid
(GA)
liposomes
encapsulated
microcapsules
system
has
desired
features
inflammatory
repair
is
presented.
As
the
bacteria
could
break
down
alginate
shells,
GA
be
controllably
released
from
microcapsules,
which
promotes
M2
polarization
regulate
their
responses
in
microenvironment.
Based
on
these,
it
demonstrated
exhibits
an
immunomodulatory
effect
healing
full‐thickness
defect
model
rats.
These
results
indicate
capabilities
of
unitized
efficient
repair,
such
valuable
clinical
applications.
Biomedical
materials
are
of
great
significance
for
preventing
and
treating
major
diseases
protecting
human
health.
At
present,
more
stringent
requirements
have
been
put
forward
the
preparation
methods
dimension
control
biomedical
based
on
urgent
demand
high-performance
materials,
especially
existence
various
physiological
size
thresholds
in
vitro/in
vivo.
Microfluidic
platforms
break
limitations
traditional
micro-/nanomaterial
synthesis,
which
provide
a
miniaturized
highly
controlled
environment
size-dependent
biomaterials.
In
this
review,
basic
conceptions
technical
characteristics
microfluidics
first
described.
Then
syntheses
with
different
dimensions
(0D,
1D,
2D,
3D)
driven
by
systematically
summarized.
Meanwhile,
applications
microfluidics-driven
including
diagnosis,
anti-inflammatory,
drug
delivery,
antibacterial,
disease
therapy,
discussed.
Furthermore,
challenges
developments
research
field
further
proposed.
This
work
is
expected
to
facilitate
convergence
between
bioscience
engineering
communities
continue
contribute
emerging
field.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 6, 2024
Abstract
Hydrogels
are
widely
used
in
tissue
engineering,
soft
robotics
and
wearable
electronics.
However,
it
is
difficult
to
achieve
both
the
required
toughness
stiffness,
which
severely
hampers
their
application
as
load‐bearing
materials.
This
study
presents
a
strategy
develop
hard
tough
composite
hydrogel.
Herein,
flexible
SiO
2
nanofibers
(SNF)
dispersed
homogeneously
polyvinyl
alcohol
(PVA)
matrix
using
synergistic
effect
of
freeze‐drying
annealing
through
phase
separation,
modulation
macromolecular
chain
movement
promotion
crystallization.
When
stress
applied,
strong
molecular
interaction
between
PVA
SNF
effectively
disperses
load
damage
substrate.
Freeze‐dried
annealed‐flexible
nanofibers/polyvinyl
(FDA‐SNF/PVA)
reaches
preferred
balance
enhanced
stiffness
(13.71
±
0.28
MPa)
(9.9
0.4
MJ
m
−3
).
Besides,
FDA‐SNF/PVA
hydrogel
has
high
tensile
strength
7.84
0.10
MPa,
super
elasticity
(no
plastic
deformation
under
100
cycles
stretching),
fast
recovery
ability
excellent
mechanical
properties
that
superior
other
hydrogels,
providing
an
effective
way
optimize
hydrogels
for
potential
applications
artificial
tendons
ligaments.
