Bioprinted vascular tissue: Assessing functions from cellular, tissue to organ levels DOI Creative Commons

Haihong Jiang,

Xueyi Li,

Tianhong Chen

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100846 - 100846

Published: Oct. 28, 2023

3D bioprinting technology is widely used to fabricate various tissue structures. However, the absence of vessels hampers ability bioprinted tissues receive oxygen and nutrients as well remove wastes, leading a significant reduction in their survival rate. Despite advancements bioinks technologies, vascular structures continue be unsuitable for transplantation compared natural blood vessels. In addition, complete assessment index system evaluating structure function vitro has not yet been established. Therefore, this review, we firstly highlight significance selecting suitable techniques they two synergize with each other. Subsequently, focusing on both vascular-associated cells tissues, provide relatively thorough functions based physiological that possess. We end review applications models, such vessel-on-a-chip, simulating pathological processes conducting drug screening at organ level. believe development fully functional will soon make great contributions engineering regenerative medicine.

Language: Английский

Light-based vat-polymerization bioprinting DOI
Riccardo Levato, Oksana Y. Dudaryeva, Carlos Ezio Garciamendez‐Mijares

et al.

Nature Reviews Methods Primers, Journal Year: 2023, Volume and Issue: 3(1)

Published: June 22, 2023

Language: Английский

Citations

81
Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds DOI Creative Commons
Xiaoyu Han, Qimanguli Saiding,

Xiaolu Cai

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Oct. 31, 2023

Abstract Blood vessels are essential for nutrient and oxygen delivery waste removal. Scaffold-repairing materials with functional vascular networks widely used in bone tissue engineering. Additive manufacturing is a technology that creates three-dimensional solids by stacking substances layer layer, mainly including but not limited to 3D printing, also 4D 5D printing 6D printing. It can be effectively combined vascularization meet the needs of vascularized scaffolds precisely tuning mechanical structure biological properties smart scaffolds. Herein, development neovascularization engineering systematically discussed terms importance tissue. Additionally, research progress future prospects printed scaffold highlighted presented four categories: scaffolds, cell-based loaded specific carriers bionic Finally, brief review additive manufacturing-tissue related tissues such as engineering, cardiovascular system, skeletal muscle, soft discussion challenges efforts leading significant advances intelligent regeneration presented.

Language: Английский

Citations

56
Multi‐Material Volumetric Additive Manufacturing of Hydrogels using Gelatin as a Sacrificial Network and 3D Suspension Bath DOI Creative Commons
Morgan B. Riffe, Matthew D. Davidson,

Gabriel Seymour

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: Jan. 20, 2024

Abstract Volumetric additive manufacturing (VAM) is an emerging layerless method for the rapid processing of reactive resins into 3D structures, where printing much faster (seconds) than other lithography and direct ink writing methods (minutes to hours). As a vial resin rotates in VAM process, patterned light exposure defines object then that has not undergone gelation can be washed away. Despite promise VAM, there are challenges with soft hydrogel materials from non‐viscous precursors, including multi‐material constructs. To address this, sacrificial gelatin used modulate viscosity support cytocompatible macromers based on poly(ethylene glycol) (PEG), hyaluronic acid (HA), polyacrylamide (PA). After printing, removed by washing at elevated temperature. print constructs, gelatin‐containing as shear‐yielding suspension bath (including HA further properties) extruded define processed defined object. Multi‐material constructs methacrylated (MeHA) methacrylamide (GelMA) printed (as proof‐of‐concept) encapsulated mesenchymal stromal cells (MSCs), local properties guide cell spreading behavior culture.

Language: Английский

Citations

34
Materials and Strategies to Enhance Melt Electrowriting Potential DOI Creative Commons

Paula G. Saiz,

Ander Reizabal, José Luis Vilas‐Vilela

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: March 6, 2024

Melt electrowriting (MEW) is an emerging additive manufacturing (AM) technology that enables the precise deposition of continuous polymeric microfibers, allowing for creation high-resolution constructs. In recent years, MEW has undergone a revolution, with introduction active properties or additional functionalities through novel polymer processing strategies, incorporation functional fillers, postprocessing, combination other techniques. While extensively explored in biomedical applications, MEW's potential fields remains untapped. Thus, this review explores characteristics from materials science perspective, emphasizing diverse range and composites processed by technique their current applications. Additionally, prospects offered postprinting techniques are explored, together synergy achieved combining melt methods. By highlighting untapped potentials MEW, aims to inspire research groups across various leverage innovative endeavors.

Language: Английский

Citations

20
Holographic tomographic volumetric additive manufacturing DOI Creative Commons
Maria Isabel Álvarez-Castaño, Andreas Erik Gejl Madsen, Jorge Madrid‐Wolff

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 11, 2025

Language: Английский

Citations

3
Integrating Microfluidics, Hydrogels, and 3D Bioprinting for Personalized Vessel-on-a-Chip Platforms DOI
San Seint Seint Aye, Zhi Fang, Mike C. L. Wu

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Advancement of vascular models from simple 2D culture to complex vessel-on-a-chip platforms through integration microfluidics, biomimetic hydrogels, and 3D bioprinting, enabling controlled investigation thrombosis mechanisms.

Language: Английский

Citations

2
Hybrid 3D Bioprinting of Sustainable Biomaterials for Advanced Multiscale Tissue Engineering DOI Open Access
Xuejiao Ma,

Mingqi Xu,

Xiaolin Cui

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract 3D printing has greatly improved the precision of cell and biomaterial placement, enabling accurate reproduction tissue models with sustainable potential. Various techniques, including inkjet printing, extrusion‐based vat photopolymerization, offer unique advantages but often fail to replicate full complexity native tissues because material scalability limitations. Hybrid bioprinting, combining multiple techniques in a single process, shown great potential creating complex multifunctional capabilities, ranging from patient‐specific implant fabrication full‐scale organ development. It capitalizes on strengths integration sustainable, renewable biomaterials at varying resolutions, nano microscale. This approach addresses both biological environmental responsibility by minimizing waste enhancing sustainability engineering processes. Despite progress, substantial gap remains between current technologies bioengineering requirements. A deep understanding hybrid its underlying mechanisms is crucial. Herein, this review summarizes discusses recent advancements systems for fabricating multiscale hierarchical models, focusing challenges field. aims insights identify key requirements advancing technology toward developing functional, biomimetic constructs.

Language: Английский

Citations

2
A review of materials used in tomographic volumetric additive manufacturing DOI Creative Commons
Jorge Madrid‐Wolff, Joseph Toombs, Riccardo Rizzo

et al.

MRS Communications, Journal Year: 2023, Volume and Issue: 13(5), P. 764 - 785

Published: Aug. 29, 2023

Volumetric additive manufacturing is a novel fabrication method allowing rapid, freeform, layer-less 3D printing. Analogous to computer tomography (CT), the projects dynamic light patterns into rotating vat of photosensitive resin. These build up three-dimensional energy dose within resin, solidifying volume desired object seconds. Departing from established sequential methods like stereolithography or digital printing, volumetric offers new opportunities for materials that can be used include viscous acrylates and elastomers, epoxies (and orthogonal epoxy-acrylate formulations with spatially controlled stiffness) formulations, tunable stiffness thiol-enes shape memory foams, polymer derived ceramics, silica-nanocomposite based glass, gelatin-based hydrogels cell-laden biofabrication. Here we review these materials, highlight challenges adapt them manufacturing, discuss perspectives they present.

Language: Английский

Citations

34
3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space DOI Creative Commons
Angelique Van Ombergen, Franziska Chalupa‐Gantner, Parth Chansoria

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: June 23, 2023

Abstract 3D bioprinting has developed tremendously in the last couple of years and enables fabrication simple, as well complex, tissue models. The international space agencies have recognized unique opportunities these technologies for manufacturing cell models basic research space, particular investigating effects microgravity cosmic radiation on different types human tissues. In addition, is capable producing clinically applicable grafts, its implementation therefore can support autonomous medical treatment options astronauts future long term far‐distant missions. article discusses but also challenges operating bioprinters under conditions, mainly microgravity. While some process steps, most which involving handling liquids, are challenging microgravity, this environment help overcome problems such sedimentation low viscous bioinks. Hopefully, publication will motivate more researchers to engage topic, with publicly available becoming at International Space Station (ISS) imminent future.

Language: Английский

Citations

30
Advances in volumetric bioprinting DOI

Sibo Jing,

Liming Lian, Yingying Hou

et al.

Biofabrication, Journal Year: 2023, Volume and Issue: 16(1), P. 012004 - 012004

Published: Nov. 3, 2023

The three-dimensional (3D) bioprinting technologies are suitable for biomedical applications owing to their ability manufacture complex and high-precision tissue constructs. However, the slow printing speed of current layer-by-layer (bio)printing modality is major limitation in biofabrication field. To overcome this issue, volumetric (VBP) developed. VBP changes layer-wise operation conventional devices, permitting creation geometrically complex, centimeter-scale constructs tens seconds. next step onward from sequential methods, opening new avenues fast additive manufacturing fields engineering, regenerative medicine, personalized drug testing, soft robotics, etc. Therefore, review introduces principles hardware designs VBP-based techniques; then focuses on recent advances (bio)inks applications. Lastly, limitations discussed together with future direction research.

Language: Английский

Citations

25