Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 53(1), P. 137 - 162

Published: Nov. 29, 2023

Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial that recapitulate the catalytic of can not circumvent enzymatic fragility but also bring versatile functions into practice. Among them, metal-organic frameworks (MOFs) featuring diverse site-isolated metal sites supramolecular have emerged as promising candidates for move toward unparalleled properties behaviour enzymes. In this review, we systematically summarize significant advances in MOF-based metalloenzyme mimics a special emphasis on active pocket engineering at atomic level, including primary secondary coordination spheres. Then, deep understanding mechanisms advanced applications are discussed. Finally, perspective emerging frontier research is provided advance bioinspired catalysis.

Language: Английский

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Recent advances in metal-organic framework-based nanozymes and their enabled optical biosensors for food safety analysis

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 173, P. 117602 - 117602

Published: Feb. 23, 2024

Language: Английский

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Engineering metal-organic frameworks-based nanozymes for enhanced biomimetic catalytic sensing

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 178, P. 117862 - 117862

Published: July 10, 2024

Language: Английский

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

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Environmental applications of metal–organic framework-based three-dimensional macrostructures: a review

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The latest advancements in MOF-based three-dimensional macrostructures, encompassing fascinating characteristics, preparation strategies, characterization methods, and environmental applications, are examined.

Language: Английский

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Recent Development of Nanoparticle Platforms for Organophosphate Nerve Agent Detoxification

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Poisoning by organophosphate (OP) nerve agents remains a pressing global threat due to their extensive use in chemical warfare and pesticides, potentially causing high morbidity mortality worldwide. This urgent need for effective countermeasures has driven considerable interest innovative detoxification approaches. Among these, nanoparticle technology stands out its multifunctional potential wide-ranging applications. review highlights recent advancements platforms developed OP detoxification, focusing on five main types: inorganic nanoparticles, lipid-based polymer-based metal–organic framework cellular nanoparticles. For each platform, we discuss representative examples that illustrate how structural functional properties enhance effectiveness as nanocarriers, nanocatalysts, or nanoscavengers, ultimately enabling safe efficient detoxification. aims stimulate further technological innovation OP-detoxifying nanoparticles encourage broader development of strategies.

Language: Английский

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Room-temperature aqueous synthesis of MOF-808(Zr) for selective adsorption of dye mixtures

Separation and Purification Technology, Journal Year: 2023, Volume and Issue: 333, P. 125957 - 125957

Published: Dec. 6, 2023

Language: Английский

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Scalable multifunctional MOFs-textiles via diazonium chemistry

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 21, 2024

Abstract Cellulose fiber-based textiles are ubiquitous in daily life for their processability, biodegradability, and outstanding flexibility. Integrating cellulose with functional coating materials can unlock potential functionalities to engage diverse applications. Metal-organic frameworks (MOFs) ideal candidate such integration, thanks unique merits, as large specific surface area, tunable pore size, species diversity. However, achieving scalable fabrication of MOFs-textiles high mechanical durability remains challenging. Here, we report a facile strategy direct MOF growth on cotton fibers grafted via the diazonium chemistry. The as-prepared ZIF-67-Cotton textile (ZIF-67-CT) exhibits excellent ultraviolet (UV) resistance organic contamination degradation peroxymonosulfate activation. ZIF-67-CT is also used encapsulate essential oils carvacrol enable antibacterial activity against E. coli S. aureus . Additionally, by directly tethering hydrophobic molecular layer onto MOF-coated surface, superhydrophobic achieved self-cleaning, antifouling, oil-water separation performances. More importantly, reported generic applicable other MOFs materials, various large-scale multi-functional be successfully manufactured, resulting vast applications wastewater purification, fragrance industry, outdoor gears.

Language: Английский

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Metal-organic frameworks and their derivatives for sustainable flame-retardant polymeric materials

Advanced Nanocomposites, Journal Year: 2024, Volume and Issue: 2, P. 1 - 14

Published: Nov. 5, 2024

Language: Английский

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Recent Advances in Metal–Organic Frameworks as Oxidase Mimics: A Comprehensive Review on Rational Design and Modification for Enhanced Sensing Applications

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based systems. This review explores various advantages that MOFs offer terms catalytic activity, low-cost, stability, structural versatility. With a primary focus on their application biochemical sensing, oxidases demonstrated remarkable utility, prompting thorough exploration design modification strategies. Moreover, aims to provide comprehensive analysis strategies employed rational MOF structures optimize key parameters such sensitivity, selectivity, stability context sensors. Through an exhaustive examination recent research developments, this article seeks insights into nuanced interplay between performance, shedding light mechanisms underpin effectiveness mimics. Finally, addresses challenges opportunities associated with aiming drive further advancements structure development highly effective sensors for diverse applications.

Language: Английский

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