Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
19(2)
Published: Nov. 22, 2023
Abstract
Enzyme‐powered
micro/nanomotors
that
can
autonomously
move
in
biological
environment
are
attractive
the
fields
of
biology
and
biomedicine.
The
fabrication
enzyme‐powered
normally
focuses
on
constructing
Janus
structures
micro/nanomaterials,
based
intuition
coating
enzymes
generate
driving
force
from
asymmetric
catalytic
reactions.
Here,
catalase‐powered
silica
(C‐MNMs),
an
archetypical
model
micro/nanomotors,
we
find
size
rather
than
catalase
determines
motion
ability
C‐MNMs.
effects
asymmetry
have
been
investigated
by
a
series
C‐MNMs
at
various
sizes
(0.5,
2,
5
10
μm)
levels
(full‐,
half‐
most‐coated
with
catalase).
performance
indicates
500
nm
2
μm
show
obvious
increases
(varying
134%
to
618%)
diffusion
coefficient,
but
bigger
no
self‐propulsion
behaviour
all,
regardless
levels.
In
addition,
although
facilitates
enhanced
C‐MNMs,
only
sensitive
level.
This
work
elucidates
primary
secondary
roles
preparation
paving
way
fabricate
high
future.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
High
transductive
loss
at
tissue
injury
sites
impedes
repair.
The
high
dissipation
characteristics
in
the
electromechanical
conversion
of
piezoelectric
biomaterials
pose
a
challenge.
Therefore,
supramolecular
engineering
and
microfluidic
technology
is
utilized
to
introduce
slide-ring
polyrotaxane
conductive
polypyrrole
construct
stress-electric
coupling
hydrogel
microspheres.
molecular
slippage
mechanism
structure
stores
releases
mechanical
energy,
reducing
loss,
barium
titanate
enables
stress-electricity
conversion,
conjugated
π-electron
movement
network
improves
internal
electron
transfer
efficiency
microspheres,
thereby
for
first
time.
Compared
traditional
low-dissipation
microspheres
increased
by
2.3
times,
energy
decreased
43%.
At
cellular
level,
electrical
signals
generated
triggered
Ca
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Mechanical
force
attracts
booming
attention
with
the
potential
to
tune
tumor
cell
behavior,
especially
in
migration.
However,
current
approach
for
introducing
mechanical
input
is
difficult
apply
vivo.
How
affects
behavior
situ
also
remains
unclear.
In
this
work,
an
intelligent
miniaturized
platform
constructed
magnetic
ZnFe
2
O
4
(ZFO)
micromotors.
The
wireless
ZFO
can
self‐assemble
and
rotate
generate
torque
of
biologically
relevant
piconewton‐scale
at
target
site.
It
observed
unexpectedly
that
enhanced
rotating
from
micromotors
active
fluid
inhibit
migration
highly
invasive
A549
cells.
down‐regulation
Piezo1
channel
suppressed
signaling
ROCK1
mechano‐adaptive
cells
found
be
related
inhibition
effect.
With
effectiveness
confirmed
zebrafish
xenograft
model,
provides
a
valuable
toolkit
mechanobiology
force‐associated
non‐invasive
therapy.
Angewandte Chemie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Developing
micro‐/nanomotors
that
convert
a
chemical
energy
input
into
local
gradient
field
and
motion
is
an
appealing
but
challenging
task
holds
particular
promise
for
the
intersection
of
materials
nanoengineering.
Over
past
two
decades,
remarkable
advancements
have
refined
these
out‐of‐equilibrium
chemically
powered
micro‐/nanomotors,
enabling
them
to
orchestrate
in
situ
transformations
dynamically
change
environments.
The
ionic
products,
radicals,
gases,
electric
fields
from
active
reshape
microenvironment,
paving
way
ecofriendly
disease
interventions.
This
review
discusses
state‐of‐the‐art
reactions
propel
energy‐consuming
elucidates
emerging
implications
their
products
on
biological
systems.
Particular
emphasis
has
been
placed
potential
neural
modulation,
reactive
oxygen
species
(ROS)
regulation,
synergistic
tumor
therapy,
antibacterial
strategies,
tissue
regeneration.
Collectively,
sketches
provide
landscape
therapeutic
modalities,
heralding
new
era
biomedicine.
By
harnessing
product
this
matter,
we
envision
paradigm
shift
toward
therapies
transcend
conventional
approaches,
promising
breakthroughs
diagnosis,
treatment,
prevention.
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Developing
micro‐/nanomotors
that
convert
a
chemical
energy
input
into
local
gradient
field
and
motion
is
an
appealing
but
challenging
task
holds
particular
promise
for
the
intersection
of
materials
nanoengineering.
Over
past
two
decades,
remarkable
advancements
have
refined
these
out‐of‐equilibrium
chemically
powered
micro‐/nanomotors,
enabling
them
to
orchestrate
in
situ
transformations
dynamically
change
environments.
The
ionic
products,
radicals,
gases,
electric
fields
from
active
reshape
microenvironment,
paving
way
ecofriendly
disease
interventions.
This
review
discusses
state‐of‐the‐art
reactions
propel
energy‐consuming
elucidates
emerging
implications
their
products
on
biological
systems.
Particular
emphasis
has
been
placed
potential
neural
modulation,
reactive
oxygen
species
(ROS)
regulation,
synergistic
tumor
therapy,
antibacterial
strategies,
tissue
regeneration.
Collectively,
sketches
provide
landscape
therapeutic
modalities,
heralding
new
era
biomedicine.
By
harnessing
product
this
matter,
we
envision
paradigm
shift
toward
therapies
transcend
conventional
approaches,
promising
breakthroughs
diagnosis,
treatment,
prevention.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 15, 2025
Hepatic
fibrosis
involves
hepatocyte
damage,
causing
blood
ammonia
accumulation,
which
exacerbates
liver
pathology
and
crosses
the
blood-brain
barrier,
inducing
hepatic
encephalopathy.
It
is
meaningful
to
construct
a
therapeutic
platform
for
targeted
clearance.
In
this
work,
biocompatible
water-powered
Zn
micromotor
constructed
as
an
chemotaxis
platform,
can
be
actuated
by
water
splitting
reaction
self-generated
Zn2+
gradient.
propel
towards
NH3·H2O
source
through
formation
of
complex
ions
[Zn(NH3)1](OH)+
[Zn(NH3)2](OH)+,
representing
generalizable
strategy
via
coordination
reaction.
vivo,
biomimetic
collective
behavior
allows
precise
navigation
reduction
intrahepatic
level,
reshaping
pathological
microenvironment.
This
mechanism,
operating
in
green,
zero-waste
manner,
facilitates
integration
these
micromotors
into
domain
biological
regulation.
Such
environment
environment-adaptive
favorable
treatment
encephalopathy
caused
hyperammonemia,
expected
provide
inspiration
future
personalized
precision
medicine.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(47), P. 32517 - 32533
Published: Nov. 11, 2024
Due
to
the
uncertain
differentiation
of
neural
stem
cells
(NSCs),
replenishing
lost
neurons
by
endogenous
repair
spinal
cord
injury
(SCI)
remains
challenging.
The
electrical
stimulation-induced
drug
release
is
a
promising
approach
for
localized
and
controlled
drugs
regulate
NSCs
into
neurons.
Here,
we
developed
Zn-PDA@BT
nanoparticles
acted
as
Trojan
Horse
enter
through
endocytosis
Zn
