Recent Advancements of Nanomedicine in Breast Cancer Surgery DOI Creative Commons

Xiangyue Meng,

Xin Wang, Zhihao Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14143 - 14169

Published: Dec. 1, 2024

Breast cancer surgery plays a pivotal role in the multidisciplinary approaches. Surgical techniques and objectives are gradually shifting from tumor complete resection towards prolonging survival, improving cosmetic outcomes, restoring social psychological well-being of patients. However, surgical treatment still faces challenges such as inadequate sensitivity sentinel lymph node localization, need to improve intraoperative boundary localization imaging, postoperative scar healing, risk recurrence, necessitating other adjunct measures for improvement. To address these challenges, specificity-optimized nanomedicines have been introduced into therapeutic landscape breast cancer. In particular, this review involves starting with an overview structure composition microenvironment then introducing guiding principle foundation design nanomedicine. Moreover, we will take order process diagnosis point, adaptively propose roles advantages nanomedicine addressing corresponding issues. Furthermore, also involved prospects utilizing advanced technological Overall, seeks uncover sophisticated strategies clinical standpoint, faced treatment, provide insights subject matter.

Language: Английский

Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing DOI Creative Commons
Lisha Yu, Z. G. Liu, Yong Zheng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

Uncontrolled haemorrhage is a leading cause of trauma-related fatalities, highlighting the critical need for rapid and effective haemostasis. Current haemostatic materials encounter limitations such as slow clotting weak mechanical strength, while most bioadhesives compromise their adhesion performance to wet tissues biocompatibility degradability. In this study, molecular self-assembly strategy proposed, developing biocompatible biodegradable protein-based patch with excellent performance. This utilizes fibrinogen modified hydrophobic groups induce into hydrogel, which converted dry patch. The protein enhances on tissue through cross-linking method robust intra/inter-molecular interactions. demonstrates efficacy in both porcine oozing wound severe acute haemorrhage. It maintains biological functionality, ensures sustained sealing gradually degrading vivo, making it promising candidate clinical applications.

Language: Английский

Citations

3
Advances of biological macromolecules hemostatic materials: A review DOI
Mengyang Zhang,

Feng Han,

Xunxin Duan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131772 - 131772

Published: April 24, 2024

Language: Английский

Citations

10
Bio‐Inspired Self‐Healing Hydrogel for Fast Hemostasis and Accelerated Wound Healing of Gastric Ulcers DOI
Na Wen, Shuangshuang Li,

Hongzhi Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

Abstract Gastric ulcers accompanied by acute or chronic bleeding represent a significant risk of fatality. However, the development effective strategies for achieving rapid hemostasis and wound healing in gastric ulcer represents formidable challenge. To address this challenge, thrombin‐derived C‐terminal peptide (TCP‐25) is employed as targeted agent, it incorporated into two novel injectable biocompatible carboxymethyl chitosan (CMCs) hydrogels via Schiff's base reaction. The TCP‐25 display optimal adaptability within distinctive gastrointestinal microenvironment, demonstrating balance acid resistance degradation, along with controlled release bioactivity, good bio‐adhesive properties. Both vitro vivo reveal that hydrogel achieves hemostasis. In an ethanol‐induced model rats, demonstrates effectively inhibits 92% 24‐h, exhibiting efficacy surpasses omeprazole medicine, commonly used clinical treatment. This enhanced performance attributed to synergistic effects CMCs hemostasis, inhibiting bacterial growth, promoting ulcers. Consequently, present work offers promising applications

Language: Английский

Citations

10
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence DOI
Zhili Li, Rui Guo, Zhiyong Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 131 - 139

Published: Feb. 21, 2024

Language: Английский

Citations

9
One Hydrophobic Coating Enables Macro- and Micro-Scale Blood Contact Activation DOI
Xiaoli Liu, Long Li,

Limin Meng

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123155 - 123155

Published: Jan. 28, 2025

Language: Английский

Citations

1
Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones DOI Creative Commons
Wang Yong-qi,

Junyi Yang,

Yirixiatijiang Amier

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1401 - 1423

Published: Feb. 1, 2025

Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial

Language: Английский

Citations

1
Biomaterials for neuroengineering: Applications and challenges DOI Creative Commons

Huanghui Wu,

E.J. Feng,

Huazong Yin

et al.

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Language: Английский

Citations

1
An In Vivo Self‐Assembled Bispecific Nanoblocker for Enhancing Tumor Immunotherapy DOI
Xingjie Hu,

Ni‐Yuan Zhang,

Da‐Yong Hou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(45)

Published: July 18, 2023

Anti-PD-L1 monoclonal antibody has achieved substantial success in tumor immunotherapy by T-cells activation. However, the excessive accumulation of extracellular matrix components induced unsatisfactory infiltration and poor penetration antibodies make it challenging to realize efficient immunotherapy. Herein, a peptide-based bispecific nanoblocker (BNB) strategy is reported for situ construction CXCR4/PD-L1 targeted nanoclusters on surface cells that are capable boosting through CXCR4 blockage enhancing activation PD-L1 occupancy, ultimately realizing high-performance Briefly, BNB selectively recognizes bonds with deep penetration, which rapidly self-assembles into cells. Compared traditional antibody, exhibits an intriguing metabolic behavior, is, elimination half-life (t1/2 ) 69.3 h ≈50 times longer than plasma (1.4 h). The higher rapid systemic clearance overcome potential side effects. Moreover, solid stress generated substantially reduced 44%, promotes efficacy. Finally, these findings strengthen extend clinical applications PD-1/PD-L1

Language: Английский

Citations

14
Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment DOI Creative Commons
Qiang Luo, Jie Luo, Zhaohui Luan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

In an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current very challenging to manage in large-diameter or deep lesions highly prone rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) reported, consisting of self-assembly sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for treatment without recurring concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β-sheet nanofiber solvent-induced form HPH gel. networks induced ultrafast coagulation enveloping blood cells activating platelets factors even coagulopathy. Besides its remarkable performance artery liver injury models, achieves instant management porcine NVUGIB models within 60 s preventing This work demonstrates extraordinary agent intervention BLE first time, broadening potential application scenarios, including patients coagulopathy promising clinical prospects.

Language: Английский

Citations

6
Emerging breakthroughs in biomaterials for orthopedic applications: A comprehensive review DOI
Md. Zobair Al Mahmud, Md Hosne Mobarak, Nayem Hossain

et al.

Bioprinting, Journal Year: 2023, Volume and Issue: 36, P. e00323 - e00323

Published: Nov. 10, 2023

Language: Английский

Citations

13