Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 9, 2024
Immune
checkpoint
blockade
(ICB)
therapy
has
emerged
as
a
new
therapeutic
paradigm
for
variety
of
advanced
cancers,
but
wide
clinical
application
is
hindered
by
low
response
rate.
Here
we
use
peptide-based,
biomimetic,
self-assembly
strategy
to
generate
nanoparticle,
TPM1,
binding
PD-L1
on
tumour
cell
surface.
Upon
with
PD-L1,
TPM1
transforms
into
fibrillar
networks
in
situ
facilitate
the
aggregation
both
bound
and
unbound
thereby
resulting
PD-1/PD-L1
pathway.
Characterizations
manifest
prolonged
retention
(
>
7
days)
anti-cancer
effects
associated
reinvigorating
CD8
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(18)
Published: Feb. 19, 2024
The
cell
membrane
is
a
crucial
component
of
cells,
protecting
their
integrity
and
stability
while
facilitating
signal
transduction
information
exchange.
Therefore,
disrupting
its
structure
or
impairing
functions
can
potentially
cause
irreversible
damage.
Presently,
the
tumor
recognized
as
promising
therapeutic
target
for
various
treatment
methods.
Given
extensive
research
focused
on
membranes,
it
both
necessary
timely
to
discuss
these
developments,
from
materials
design
specific
biomedical
applications.
This
review
covers
treatments
based
functional
targeting
membrane,
ranging
well-known
membrane-anchoring
photodynamic
therapy
recent
lysosome-targeting
chimaeras
protein
degradation.
diverse
mechanisms
are
introduced
in
following
sections:
phototherapy,
self-assembly
situ
biosynthesis
degradation
proteins
by
chimeras.
In
each
section,
we
outline
conceptual
general
derived
numerous
studies,
emphasizing
representative
examples
understand
advancements
draw
inspiration.
Finally,
some
challenges
future
directions
membrane-targeted
our
perspective.
aims
engage
multidisciplinary
readers
encourage
researchers
related
fields
advance
fundamental
theories
practical
applications
membrane-targeting
agents.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(18)
Published: Feb. 19, 2024
Abstract
The
cell
membrane
is
a
crucial
component
of
cells,
protecting
their
integrity
and
stability
while
facilitating
signal
transduction
information
exchange.
Therefore,
disrupting
its
structure
or
impairing
functions
can
potentially
cause
irreversible
damage.
Presently,
the
tumor
recognized
as
promising
therapeutic
target
for
various
treatment
methods.
Given
extensive
research
focused
on
membranes,
it
both
necessary
timely
to
discuss
these
developments,
from
materials
design
specific
biomedical
applications.
This
review
covers
treatments
based
functional
targeting
membrane,
ranging
well‐known
membrane‐anchoring
photodynamic
therapy
recent
lysosome‐targeting
chimaeras
protein
degradation.
diverse
mechanisms
are
introduced
in
following
sections:
phototherapy,
self‐assembly
situ
biosynthesis
degradation
proteins
by
chimeras.
In
each
section,
we
outline
conceptual
general
derived
numerous
studies,
emphasizing
representative
examples
understand
advancements
draw
inspiration.
Finally,
some
challenges
future
directions
membrane‐targeted
our
perspective.
aims
engage
multidisciplinary
readers
encourage
researchers
related
fields
advance
fundamental
theories
practical
applications
membrane‐targeting
agents.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(45)
Published: July 24, 2024
Abstract
The
strategy
of
in
vivo
self‐assembly
has
been
developed
for
improved
enrichment
and
long‐term
retention
anticancer
drug
tumor
tissues.
However,
most
self‐assemblies
with
non‐covalent
bonding
interactions
are
susceptible
to
complex
physiological
environments,
leading
weak
stability
loss
biological
function.
Here,
we
develop
a
coupling‐induced
assembly
(CIA)
generate
covalently
crosslinked
nanofibers,
which
is
applied
situ
constructing
artificial
shell
on
mitochondria.
oxidation‐responsive
peptide‐porphyrin
conjugate
P1
synthesized,
self‐assemble
into
nanoparticles.
Under
the
oxidative
microenvironment
mitochondria,
coupling
thiols
causes
formation
dimers,
further
ordered
stacked
nanofibers.
As
result,
constructed
mitochondria
efficiently
through
multivalent
cooperative
due
increased
binding
sites.
ultrasound
(US)
irradiation,
porphyrin
molecules
produce
large
amount
reactive
oxygen
species
(ROS)
that
act
adjacent
mitochondrial
membrane,
exhibiting
~2‐fold
higher
antitumor
activity
than
nanoparticles
vitro
vivo.
Therefore,
mitochondria‐targeted
CIA
provides
novel
perspective
sonodynamic
therapy
(SDT)
shows
potential
applications
therapies.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 1, 2025
ABSTRACT
Cancer
remains
the
leading
cause
of
patient
death
worldwide
and
its
incidence
continues
to
rise.
Immunotherapy
is
rapidly
developing
due
significant
differences
in
mechanism
action
from
conventional
radiotherapy
targeted
antitumor
drugs.
In
past
decades,
many
biomaterials
have
been
designed
prepared
construct
therapeutic
platforms
that
modulate
immune
system
against
cancer.
Immunotherapeutic
utilizing
can
markedly
enhance
efficacy
by
optimizing
delivery
agents,
minimizing
drug
loss
during
circulation,
amplifying
immunomodulatory
effects.
The
intricate
physiological
barriers
tumors,
coupled
with
adverse
environments
such
as
inadequate
infiltration,
off‐target
effects,
immunosuppression,
emerged
obstacles
impeding
effectiveness
oncology
therapy.
However,
most
current
studies
are
devoted
development
complex
immunomodulators
exert
functions
loading
drugs
or
adjuvants,
ignoring
tumors.
Compared
biomaterials,
biomimetic
nanomaterials
based
on
peptide
situ
self‐assembly
excellent
functional
characteristics
biocompatibility,
biodegradability,
bioactivity
a
novel
effective
tool
for
cancer
immunotherapy.
This
article
presents
comprehensive
review
latest
research
findings
tumor
Initially,
we
categorize
structural
types
elucidate
their
intrinsic
driving
forces.
Subsequently,
delve
into
strategies
these
nanomaterials,
highlighting
advantages
Furthermore,
detail
applications
antigen
presentation
modulation
microenvironment.
conclusion,
encapsulate
challenges
prospective
developments
clinical
translation
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Increasing
evidence
has
demonstrated
the
critical
role
of
lysosomes
in
tumor
progression,
as
well
their
involvement
drug
resistance
during
cancer
treatment.
However,
exploitation
lysosome-targeting
agents
to
inhibit
malignant
cell
growth
is
still
high
demand.
Herein,
we
report
an
alkaline
phosphatase
(ALP)-responsive
peptide-based
precursor
(C1)
that
selectively
induced
lysosome
dysfunction
uveal
melanoma
cells
via
noncontact
light
manipulation.
We
C1
was
dephosphorylated
upon
close
contact
with
ALP-upregulated
cells,
endocytosed,
and
accumulated
lysosomes.
Further
irradiation
facilitated
generation
two
self-sorting
components
self-assembled
form
nanofibrils
nanorods,
respectively.
Mesoscale
interactions
between
these
nanostructures
triggered
formation
robust
double-network
assemblies
within
lysosomes,
resulting
lysosomal
membrane
permeabilization
death.
By
strategically
utilizing
ALP
activity,
responsiveness,
acidity
design
a
self-assembling
precursor,
have
developed
capable
disrupting
integrity
effectively
inhibiting
cells.
These
findings
provide
valuable
insights
for
advancement
therapeutic
agents.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7750 - 7750
Published: Nov. 24, 2023
Advances
in
nanotechnology
have
brought
innovations
to
cancer
therapy.
Nanoparticle-based
anticancer
drugs
achieved
great
success
from
bench
bedside.
However,
insufficient
therapy
efficacy
due
various
physiological
barriers
the
body
remains
a
key
challenge.
To
overcome
these
biological
and
improve
therapeutic
of
cancers,
multistage
self-assembled
nanomaterials
with
advantages
stimuli-responsiveness,
programmable
delivery,
immune
modulations
provide
opportunities.
In
this
review,
we
describe
typical
for
nanomedicines,
discuss
recent
achievements
stimuli-responsive
drug
highlighting
delivery
nanomaterials,
situ
transformable
immune-reprogramming
nanomaterials.
Ultimately,
perspective
future
opportunities
challenges
immunotherapy.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(7), P. 4347 - 4358
Published: June 6, 2024
In
order
to
improve
the
effectiveness
of
tumor
treatment
and
reduce
toxic
side
effects
drugs,
we
formed
carrier-free
multifunctional
nanoparticles
(BI
NPs)
by
noncovalent
interaction
berberine
hydrochloride
IR780.
BI
NPs
possessed
synergistic
promoting
apoptosis,
inhibiting
proliferation
metastasis
tumors,
phototherapeutic
treatment.
Dispersive
passive
targeting
ability
retention
(EPR)
on
sites
in
vivo
could
be
monitored
fluorescence
imaging.
addition,
exhibited
effective
reactive
oxygen
species
(ROS)
generation
photothermal
conversion
capabilities,
photodynamic
therapy
(PDT),
(PTT).
Importantly,
inhibit
suppression
through
AMPK/PI3K/AKT
signaling
pathway
metastasis.
not
only
have
efficient
multimodal
therapeutic
but
also
good
biosafety
potential
clinical
applications.
