Carbon, Journal Year: 2025, Volume and Issue: 234, P. 119980 - 119980
Published: Jan. 4, 2025
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 6, 2024
Abstract Carbon quantum dots (CQDs) have versatile applications in luminescence, whereas identifying optimal synthesis conditions has been challenging due to numerous parameters and multiple desired outcomes, creating an enormous search space. In this study, we present a novel multi-objective optimization strategy utilizing machine learning (ML) algorithm intelligently guide the hydrothermal of CQDs. Our closed-loop approach learns from limited sparse data, greatly reducing research cycle surpassing traditional trial-and-error methods. Moreover, it also reveals intricate links between target properties unifies objective function optimize like full-color photoluminescence (PL) wavelength high PL yields (PLQY). With only 63 experiments, achieve fluorescent CQDs with PLQY exceeding 60% across all colors. study represents significant advancement ML-guided synthesis, setting stage for developing new materials properties.
Language: Английский
Citations
52
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)
Published: May 1, 2024
Abstract The precision treatment of tumors with minimal side effects is associated improved human health and quality life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, effects. Carbon dots (CDs) are considered promising reagents because their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric photothermal conversion properties, outstanding biocompatibility. This review summarizes advancements photo‐responsive CDs for photodynamic the emerging photocatalytic tumors. Finally, article discusses main challenges development oncology therapeutics strategies overcome these challenges.
Language: Английский
Citations
50
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)
Published: March 4, 2024
Abstract Carbon dots (CDs) are a burgeoning star of luminescent carbon‐based nanomaterials with emerging interest for various applications. Luminescence from the sp 2 ‐conjugated domains in carbon cores is considered to be intrinsic bandgap emission CDs, whereas relationship between them remains poorly understood. Simultaneously, solvent relaxation water molecules will quench fluorescence thus, obtaining strong luminescence CDs aqueous solutions great challenge. Herein, facile one‐step spatial‐confined cross‐condensation method that uses heat‐induced self‐foaming process ambient pressure has been developed synthesize highly unprecedented photoluminescence quantum yield (PLQY) over 97.2% water. The unique precursor‐derived cross‐arranged perylene skeleton hinders π–π stacking, while hydrophobicity conjugated units mitigates by molecules, resulting near‐unity PLQY solutions, enabling this demonstrate first optically pumped green lasing solution. Moreover, biomaterial‐based white light emitting diode fabricated using CDs‐stained silks as conversion cover realize high luminous efficiency 60.7 lm W −1 CIE color coordinate (0.33, 0.35).
Language: Английский
Citations
34
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 12, 2024
Abstract Carbon dots (CDs) are highly desired in biological applications. However, achieving a balance between photoluminescence (PL) efficiency and photothermal conversion (PTCE) is challenging. In this study, an unprecedent combination of efficient red fluorescence high PTCE the second near‐infrared (NIR‐II) window sodium‐doped CDs system reported. Upon 808 nm laser irradiation, photo‐induced oxidation–reduction reactions happened on surface sodium cation‐functionalized (Na‐CDs), leading to partial reduction surface‐functionalized (Na) ions. The photo‐reduced Na atoms coordinated with sp 2 C domains core, resulting Na‐doped (ir‐Na‐CDs) enhanced absorption band NIR‐II 43% under 1064 irradiation (1 W cm −2 ). Composing ir‐Na‐CDs bovine serum albumin (BSA) PLQY emission 31% water without diminishing region. Transient spectra revealed that no energy transfer occurred center band, revealing novel independent Janus photophysical processes. Moreover, ir‐Na‐CDs@BSA exhibited negligible low cytotoxicity demonstrated tumor accumulation capacity after intravenous injection, enabling effective therapy
Language: Английский
Citations
24
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Abstract Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cells, due to their highly immunogenic properties, present a promising avenue the development of WCCV. However, successful WCCV based on pyroptotic cells yet be accomplished. Here, facile strategy that utilized photocatalytic carbon dots (CDs) induce pyroptosis fabricating reported. Photocatalytic CDs are capable generating substantial amounts hydroxyl radicals can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers through reactive oxygen species (ROS)‐mitochondria‐caspase 3‐gasdermin E pathway proton motive force‐driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these CDs‐induced (PCIP) hyperactivate macrophage (M0–M1) upregulation major histocompatibility complex class II expression. In vivo, PCIP induced specific immune‐preventive effects melanoma breast mouse models anticancer immune memory, demonstrating effective work provides novel insights inducing bridges gap fabrication cells.
Language: Английский
Citations
21
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)
Published: May 20, 2024
Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.
Language: Английский
Citations
20
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)
Published: Nov. 2, 2023
Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic noninvasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits clinical outcomes. Although several metabolic interventions have been devoted ameliorate immunosuppression, intracellular residual LA still remains a potential energy source for oncocyte proliferation. Herein, an immunomodulatory nanoadjuvant based on yolk-shell CoP/NiCoP (CNCP) heterostructure loaded with the monocarboxylate transporter 4 inhibitor fluvastatin sodium (Flu) is constructed concurrently relieve immunosuppression elicit robust antitumor immunity. Under NIR irradiation, CNCP heterojunctions exhibit superior photothermal performance photocatalytic production of reactive oxygen species hydrogen. The continuous heat then facilitates Flu release restrain exudation from tumor cells, whereas cumulative can be depleted as hole scavenger improve efficiency. Subsequently, potentiated therapy not only initiate systematic immunoreaction, but also provoke severe mitochondrial dysfunction disrupt supply shock protein synthesis, in turn realizing mild therapy. Consequently, remodeling endows intensive cascade treatment optimal safety profile effectually suppress proliferation metastasis, which offers new paradigm development metabolism-regulated immunotherapy.
Language: Английский
Citations
25
Nano Letters, Journal Year: 2024, Volume and Issue: 24(10), P. 3028 - 3035
Published: Feb. 27, 2024
Multicolor afterglow patterns with transparent and traceless features are important for the exploration of new functionalities applications. Herein, we report a direct in situ patterning technique fabricating carbon dots (CDs) based on laser writing (LDW) first time. We explore facile step-scanning method that reduces heat-affected zone avoids uneven heating, thus producing fine-resolution CD pattern minimum line width 80 μm. Unlike previous LDW-induced luminescence patterns, patterned films transparent, which is mainly attributed to uniform heat distribution gentle temperature rise process. Interestingly, by regulating parameters precursors, an increased carbonization oxidation degree CDs could be obtained, enabling time-dependent, tunable colors from blue red. In addition, demonstrate their potential applications fabrication flexible stretchable optoelectronics.
Language: Английский
Citations
11
Journal of Alloys and Compounds, Journal Year: 2024, Volume and Issue: 983, P. 173944 - 173944
Published: Feb. 22, 2024
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160311 - 160311
Published: Feb. 1, 2025
Language: Английский
Citations
1