Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Language: Английский

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Cancer stem cells: advances in knowledge and implications for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 5, 2024

Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.

Language: Английский

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A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215600 - 215600

Published: Dec. 14, 2023

Language: Английский

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Peptide‐Based Supramolecular Therapeutics for Fighting Major Diseases

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)

Published: Feb. 21, 2024

Abstract Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines based on peptide or derivatives self‐assembly that are constructed in vitro vivo. Benefiting from the inherent advantages of peptides, such as good biocompatibility, high bioactivity, and flexible tunability, reported PST have shown excellent application prospects combating many major diseases including cancer, cardiovascular disease, infectious autoimmune metabolic so on. Through thoughtful design, can be fabricated various forms, self‐assembled precursor molecules, functional nano‐assemblies, macroscopic large‐scale hydrogels. The involved peptides play different roles, serving drug carriers for effective delivery, acting scaffold materials cell culture, functioning bioactive sequences treating diseases. In this review, a comprehensive overview traditional strategies is provided build emphasize their therapeutic applications fighting pose threat human life health. Moreover, main challenges systems application, clinical translation also briefly discussed. It hoped review arouse much more attention paid promote its practical biomedical field.

Language: Английский

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Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 24, 2025

The acidic tumor microenvironment, a hallmark of many solid tumors, is primarily induced by the high glycolytic rate cells. To avoid acidosis, cells ingeniously maintain an extracellular pH while keeping relatively alkaline intracellular pH. Overturning unique gradient has exhibited to be viable approach for cancer therapy. In this review, formation and regulatory mechanisms microenvironment in tumors will firstly outlined. Subsequently, we comprehensively summarize latest advancements anti-tumor therapy via using nanomedicines manipulate gradient, including acidifying environment alkalizing environment. Following this, discuss future potential strategies employing reverse gradient. This review aims foster research on therapeutic approaches targeting regulation holds optimistic outlook development field.

Language: Английский

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Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 819 - 846

Published: Aug. 23, 2023

Language: Английский

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Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(28)

Published: April 24, 2024

Abstract Self‐assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting‐hydrolysis‐transformation (THT) assembly of glycosylated peptides holistically resembling infection efficient cargo delivery combined tumor therapy. We design peptide via incorporating β‐galactose‐serine residue into bola‐amphiphilic sequences. Co‐assembling with two counterparts containing irinotecan (IRI) or ligand TSFAEYWNLLSP (PMI) results formation co‐assemblies SgVEIP , which target cancer β‐galactose‐galectin‐1 association undergo galactosidase‐induced morphological transformation. While GSH‐reduction causes release IRI co‐assemblies, PMI moieties p53 facilitate cell death binding protein MDM2. Cellular experiments show membrane targeting, endo‐/lysosome‐mediated internalization situ nanofibers cytoplasm . This THT process enables secreting Gal‐1 overexpressing β‐galactosidase. In vivo studies illustrate enhanced accumulation retention thereby suppressing growth. Our findings demonstrate an mimicking infection, thus providing new route therapy future.

Language: Английский

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Nanodelivery Systems as a Novel Strategy to Overcome Treatment Failure of Cancer

Small Methods, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 17, 2023

Abstract Despite the tremendous progress in cancer treatment recent decades, cancers often become resistant due to multiple mechanisms, such as intrinsic or acquired multidrug resistance, which leads unsatisfactory effects accompanying metastasis and recurrence, ultimately failure. With a deeper understanding of molecular mechanisms tumors, researchers have realized that designs targeting tumor resistance would be promising strategy break therapeutic deadlock. Nanodelivery systems excellent physicochemical properties, including highly efficient tissue‐specific delivery, substantial specific surface area, controllable chemistry, endow nanodelivery with capabilities precise targeting, deep penetration, responsive drug release, codelivery, multimodal synergy, are currently widely used biomedical researches bring new dawn for overcoming resistance. Based on this review summarizes research improve efficacy years offers prospects challenges application

Language: Английский

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Sequential Targeted Enzyme‐Instructed Self‐Assembly Supramolecular Nanofibers to Attenuate Intervertebral Disc Degeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Sept. 2, 2024

Abstract As an age‐related disease, intervertebral disc degeneration is closely related to inflammation and aging. Inflammatory cytokines cellular senescence collectively contribute the degradation of disc. Blocking this synergy reduces extracellular matrix damage caused by In study, drug‐loaded nanofibers with sequential targeting functions are constructed through intelligent response, hydrophilicity, in situ self‐assembly empowerment flurbiprofen. The peptide precursor responds cleavage overexpressed MMP‐2 degenerative microenvironment (intracellular extracellular), resulting formation self‐assembled that enable on‐demand release flurbiprofen COX‐2 response. vitro, Comp. 1 (Flurbiprofen‐GFFYPLGLAGEEEERGD) expression inflammation‐related genes proteins polarization M1 macrophages competitively inhibiting increases COL‐2 aggrecan. Additionally, it can reduce Senescence‐Associated Secretory Phenotype DNA aged nucleus pulposus cells promote recovery proliferation cell cycle. vivo, delay preventing accumulation senescent cells. Therefore, sequentially targeted blocking synergistic effect inflammatory senescence.

Language: Английский

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Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

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