Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 426, P. 137085 - 137085
Published: Dec. 5, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Abstract Adenosine triphosphate (ATP), the primary energy currency in cells, is dynamically regulated across different subcellular compartments. The ATP interplay between mitochondria and endoplasmic reticulum (ER) underscores their coordinated roles various biochemical processes, highlighting necessity for precise profiling of dynamics. Here we present an exogenously endogenously dual‐regulated DNA nanodevice spatiotemporally selective, subcellular‐compartment specific signal amplification sensing. system allows exogenous NIR light‐controlled spatiotemporal localization activation aptamer sensor or ER, while a endogenous enzyme organelles further drives via consumption molecular beacon fuels, resulting significantly enhanced sensitivity spatial precision organelle interest. Furthermore, demonstrate application this robust monitoring fluctuations ER following drug interventions. This advancement provides powerful tool improving our understanding cellular energetics at level holds potential development targeted therapeutics.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149517 - 149517
Published: Feb. 10, 2024
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(36)
Published: June 14, 2024
Mitochondria, one of the most important organelles, represent a crucial subcellular target for fundamental research and biomedical applications. Despite significant advances in design DNA nanotechnologies variety bio-applications, dearth strategies that enable mitochondria targeting molecular imaging therapy remains an outstanding challenge this field. In Minireview, we summarize recent progresses on emerging application nanotechnology mitochondria-targeted tumor treatment. We first highlight engineering mitochondria-localized nanosensors situ detection diverse key molecules are essential to maintain mitochondrial functions, including microRNA, enzymes, small molecules, metal ions. Then, compile developments anti-tumor therapy, modularly designed nanodevices delivery therapeutic agents, programmed assembly interference. will place emphasis clarification chemical principles how nanobiotechnology can be various Finally, remaining challenges future directions field discussed, hoping inspire further development advanced toolkits both academic clinical regarding mitochondria.
Language: Английский
Citations
12
Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1350, P. 343794 - 343794
Published: Feb. 13, 2025
Language: Английский
Citations
1
Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract Adenosine triphosphate (ATP), the primary energy currency in cells, is dynamically regulated across different subcellular compartments. The ATP interplay between mitochondria and endoplasmic reticulum (ER) underscores their coordinated roles various biochemical processes, highlighting necessity for precise profiling of dynamics. Here we present an exogenously endogenously dual‐regulated DNA nanodevice spatiotemporally selective, subcellular‐compartment specific signal amplification sensing. system allows exogenous NIR light‐controlled spatiotemporal localization activation aptamer sensor or ER, while a endogenous enzyme organelles further drives via consumption molecular beacon fuels, resulting significantly enhanced sensitivity spatial precision organelle interest. Furthermore, demonstrate application this robust monitoring fluctuations ER following drug interventions. This advancement provides powerful tool improving our understanding cellular energetics at level holds potential development targeted therapeutics.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105911 - 105911
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116286 - 116286
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117404 - 117404
Published: March 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: April 27, 2025
The COVID-19 pandemic, caused by the virus SARS-CoV-2 infection, has underscored critical importance of rapid and accurate therapeutics. neutralization is paramount in controlling spread impact COVID-19. In this context, integration aptamers aptamer-related nanotherapeutics presents a valuable scientifically significant approach. Despite potential, current reviews area are often not comprehensive specific enough to encapsulate full scope therapeutic principles, strategies, advancements, challenges. This review aims fill that gap providing an in-depth examination role their related molecular medicine We first introduce unique properties, selection, recognition mechanism bind with high affinity various targets. Next, we delve into potential aptamers, focusing on ability inhibit viral entry replication, as well modulate host immune response. nucleic acid nanomedicine explored. Finally, address challenges future perspectives aptamer therapeutics, including issues stability, delivery, manufacturing scalability. conclude underscoring continued research development field meet ongoing posed pandemics. Our will be resource for researchers clinicians interested latest developments at intersection biology, nanotechnology, infectious disease management.
Language: Английский
Citations
0