Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Platelet‐rich
plasma
(PRP)
is
characterized
by
elevated
concentrations
of
growth
factors
that
facilitate
bone
repair.
Nonetheless,
the
effective
integration
PRP
with
implants
and
sustained
release
its
active
constituents
pose
significant
challenges.
In
this
study,
thrombin
grafted
onto
surface
polyetheretherketone
(PEEK)
via
an
N,N'‐Disuccinimidyl
Carbonate
(DSC)
linker
retained
enzymatic
activity
enables
controlled
activation
self‐assembly,
resulting
in
formation
a
functional
bio‐gel
layer.
The
optimal
concentration
to
be
100
U/
mL
−1
determined,
at
which
point
both
grafting
amount
reaches
their
peak,
no
further
increases
observed
higher
concentrations.
solutions
varying
platelet
enrichment
ratios
are
subsequently
activated
on
thrombin‐grafted
PEEK
surface,
yielding
self‐assembled
bio‐gels
capable
factor
for
up
16
days.
thrombin‐activated
not
only
enhances
vitro
cell
adhesion,
proliferation,
osteogenic
differentiation,
vascularization
specific
polarization
macrophages,
but
also
effectively
facilitates
vivo
angiogenesis,
immunomodulation
dose‐dependent
manner.
Consequently,
gel
presents
promising
strategy
biological
functionalization
orthopedic
applications.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: March 25, 2024
Abstract
Deep
burns
lead
to
extensive
damage
the
dermal
layer,
necessitating
a
longer
treatment
duration
than
typical
skin
injuries.
Such
burn
wounds
become
more
susceptible
drug‐resistant
bacterial
infections,
thereby
complicating
and
prolonging
therapeutic
process.
In
this
study,
unique
spray
composed
of
covalent
metal
hybrid‐linked
organic
frameworks
(HLOF)
material
is
developed
that
effectively
eradicates
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
within
20
min
by
disrupting
MRSA's
surface
electrons,
destroying
its
cell
membrane
structure,
ultimately
causing
demise
with
an
impressive
antibacterial
rate
96.7%.
This
HLOF
exhibited
exceptional
biological
activity
stability.
During
wound
recovery
procedure,
promoted
expression
Vascular
endothelial
growthfactor(VEGF)
stimulate
angiogenesis
while
inhibiting
proinflammatory
factor
Tumor
necrosis
alpha
(TNF‐α)
eliminate
inflammation
further
enhance
repair.
study
presents
innovative
approach
for
achieving
outstanding
properties
improved
biocompatibility
through
modifications
made
common
(MOFs),
thus
expanding
their
potential
applications.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 9, 2024
Since
wound
healing
is
one
of
the
most
important
medical
challenges
and
common
dressings
have
not
been
able
to
manage
this
challenge
well
today,
efforts
increased
achieve
an
advanced
dressing.
Mesenchymal
stem
cells
exosomes
derived
from
them
shown
high
potential
in
regenerating
wounds
due
their
immunomodulatory,
anti-inflammatory,
immunosuppressive,
regenerative
capacities.
However,
such
as
short
life
these
cells,
low
durability
area,
stability
resulted
limitations
use
for
healing.
Nowadays,
different
scaffolds
are
considered
suitable
biomaterials
These
made
natural
or
synthetic
polymers
promising
ideal
dressing
that
does
disadvantages
dressings.
One
strategies
has
attracted
much
attention
today
using
seeding
delivering
MSCs
exosomes.
This
combined
strategy
a
enhancing
shelf
increasing
In
review,
combination
with
comprehensively
discussed.
FASEB BioAdvances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 18, 2025
Abstract
Transplanted
adipose
stem
cells
(ASC)
have
a
low
survival
rate
in
the
body,
and
there
are
not
many
ASC
that
can
be
effectively
used,
which
weakens
their
tissue
repair
function.
Based
on
this
status
quo,
new
type
of
copper‐based
metal–organic
network
(Cu‐MON)
was
used
to
pretreat
regulate
cell
activity
order
improve
efficacy
therapy
or
reduce
number
thus
reducing
cost
clinical
treatment.
Gene
expression
changes
before
after
Cu‐MON
treatment
normal
donor
(ND‐ASC)
2
diabetes
mellitus
(T2DM‐ASC)
were
evaluated
through
RNA
sequencing,
KEGG
GO
enrichment
analysis.
The
results
showed
improved
quality
by
regulating
immune
response
promoting
paracrine
secretion.
IL‐17
signaling
pathway
IL‐6,
CXCL8,
MMP‐9
key
pathways
necessary
genes
affected
ability
cells.
In
addition,
also
antiviral
Type
I
interferon
pathway.
Our
research
had
response,
secretion,
improving
capabilities.
This
approach
biomaterial
pretreatment
is
fast,
convenient,
relatively
safe,
provides
strategies
for
efficiency
therapies.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Platelet‐rich
plasma
(PRP)
is
characterized
by
elevated
concentrations
of
growth
factors
that
facilitate
bone
repair.
Nonetheless,
the
effective
integration
PRP
with
implants
and
sustained
release
its
active
constituents
pose
significant
challenges.
In
this
study,
thrombin
grafted
onto
surface
polyetheretherketone
(PEEK)
via
an
N,N'‐Disuccinimidyl
Carbonate
(DSC)
linker
retained
enzymatic
activity
enables
controlled
activation
self‐assembly,
resulting
in
formation
a
functional
bio‐gel
layer.
The
optimal
concentration
to
be
100
U/
mL
−1
determined,
at
which
point
both
grafting
amount
reaches
their
peak,
no
further
increases
observed
higher
concentrations.
solutions
varying
platelet
enrichment
ratios
are
subsequently
activated
on
thrombin‐grafted
PEEK
surface,
yielding
self‐assembled
bio‐gels
capable
factor
for
up
16
days.
thrombin‐activated
not
only
enhances
vitro
cell
adhesion,
proliferation,
osteogenic
differentiation,
vascularization
specific
polarization
macrophages,
but
also
effectively
facilitates
vivo
angiogenesis,
immunomodulation
dose‐dependent
manner.
Consequently,
gel
presents
promising
strategy
biological
functionalization
orthopedic
applications.
