Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 13(3), P. 821 - 843
Published: Nov. 27, 2024
Nebulized inhalation is a non-invasive drug delivery method with fast onset, low dosage, and fewer side effects. This review covers its principles, devices, clinical applications, future trends in respiratory systemic diseases.
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
4
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5417 - 5436
Published: Aug. 28, 2024
There has been growing interest in polymeric systems that break down or undergo property changes response to stimuli. Such polymers can play important roles biological systems, where they be used control the release of therapeutics, modulate imaging signals, actuate movement, direct growth cells. In this Perspective, after discussing most stimuli relevant applications, we will present a selection recent exciting developments. The importance stimuli-responsive polysaccharides discussed, followed by variety for delivery small molecule drugs and nucleic acids. Switchable emerging area therapeutic measurement theranostics described. Then, diverse functions achieved using hydrogels cross-linked covalently, as well various dynamic approaches presented. Finally, discuss some challenges future perspectives field.
Language: Английский
Citations
13
Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122645 - 122645
Published: May 28, 2024
Language: Английский
Citations
12
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111032 - 111032
Published: March 1, 2025
Language: Английский
Citations
1
Materials Futures, Journal Year: 2024, Volume and Issue: 3(3), P. 032501 - 032501
Published: July 4, 2024
Abstract With the advent of internet things and artificial intelligence, flexible portable pressure sensors have shown great application potential in human-computer interaction, personalized medicine other fields. By comparison with traditional inorganic materials, polymeric materials conformable to human body are more suitable for fabrication wearable sensors. Given consumption a huge amount electronics near future, it is necessary turn their attention biodegradable polymers toward development requirement green sustainable electronics. In this paper, structure properties silk fibroin (SF) introduced, source research progress piezoelectric SF systematically discussed. addition, paper summarizes advance studies on SF-based capacitive, resistive, triboelectric, reported recent years, focuses methods applications. Finally, also puts forward future trend high-efficiency corresponding It offers new insights into design bioelectronics vitro vivo sensing
Language: Английский
Citations
6
International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(4)
Published: Feb. 21, 2024
Lung cancer represents a marked global public health concern. Despite existing treatment modalities, the average 5‑year survival rate for patients with lung is only ~20%. As there are numerous adverse effects of systemic administration routes, an urgent need to develop novel therapeutic strategy tailored specifically cancer. Non‑invasive aerosol inhalation, as route drug administration, holds unique advantages in context respiratory diseases. Nanoscale materials have extensive applications field biomedical research recent years. The present study provides comprehensive review classification, summarized according clinical modalities and challenges associated inhalable micron/nanoparticle delivery systems (DDSs) Achieving localized preclinical models through inhalation deemed feasible. However, further required substantiate efficacy long‑term safety DDSs management
Language: Английский
Citations
5
Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: unknown, P. 116449 - 116449
Published: March 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 143067 - 143067
Published: April 11, 2025
Language: Английский
Citations
0
Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
ABSTRACT Membraneless organelles (MLOs) are a type of subcellular compartment structure discovered in eukaryotes recent years. They mainly formed through the liquid–liquid phase separation (LLPS) and aggregation macromolecular substances such as proteins or nucleic acids cells. When cells stimulated, they initiate series stress responses including gene transcription, RNA metabolism, translation, protein modification signal transduction to maintain homeostasis. The dysregulation these cellular processes is key event occurrence development cancer. This article provides an overview function membraneless organelles, well mechanisms separation, summarise latest research progress on tumours. It focuses role molecular mechanism LLPS tumours, with aim providing new theoretical references for developing drug action targets innovative treatment strategies.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Enhanced bone healing within 1 week after post-titanium (Ti) dental implant surgery especially contributes to the subsequent long-term osseointegration, and commonly used drug-loaded TiO2 nanotubes (TNTs) can promote osteogenesis yet still face challenge of burst drug release that makes it difficult maintain effective concentrations good osseointegration. Here, we prepared a double loading/release system silk fibroin/mesoporous silica nanoparticles (SF/MSN) nanocomposite coating modified TNTs (TAMA) with AZD2858 (Wnt/β-catenin pathway agonist for promoting osteogenesis) as therapeutic drug, realizing stable better osteogenesis. The increased β-sheet content SF reduced degradation rate SF/MSN coating, thus avoiding release. adsorption MSN maintained concentration more than was critical early healing. Under protection TAMA showed well-organized spatial AZD2858, well enabling osteogenic differentiation mineralization at cellular level up 21 days. Animal experiments further demonstrated slow in effectively activated Wnt/β-catenin pathway, rapid stage implantation finally achieving best osseointegration efficacy. Thus, this study proposed an efficient strategy developing high-performance implants via construction biodegradable coating.
Language: Английский
Citations
0