Polymeric Nanoparticles Simultaneously Delivering Paclitaxel Prodrug and Combretastatin A4 with Exceptionally High Drug Loading for Cancer Combination Therapy

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Nanomedicines capable of delivering multiple drugs have become essential in combination therapy. However, the challenges low drug loading capacity (DLC) and difficulties administering dosages between different significantly limit antitumor efficacy. In this study, a nanomedicine constructed through rational prodrug nanocarrier design was reported for cancer Initially, phenylborate ester (PBE) group-modified paclitaxel (PTX) (PTX-PBE) synthesized could self-assemble water. Subsequently, combretastatin A4 (CA4) polymer conjugates, mPEG-PCA4 (PCA4), were as nanocarriers to facilitate exceptionally high PTX-PBE precisely controlled manner. Both vitro vivo experiments demonstrated that PCA4 nanoparticles (PCA4/PTX-PBE NPs) exhibited potent efficacy favorable biocompatibility. Our approach provides straightforward, efficient, controllable strategy co-delivery pharmaceuticals clinical

Language: Английский

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Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Mussel-inspired Integrated functional 3D printed scaffolds with molybdenum disulfide nanoflowers for tumor therapy and bone reconstruction

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161399 - 161399

Published: March 1, 2025

Language: Английский

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Prodrug-designed nanocarrier co-delivering chemotherapeutic and vascular disrupting agents with exceptionally high drug loading capacity

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113628 - 113628

Published: March 1, 2025

Language: Английский

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Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Biopolymer-based bone scaffold for controlled Pt (IV) prodrug release and synergistic photothermal-chemotherapy and immunotherapy in osteosarcoma

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 9, 2025

Achieving bone defect repair while preventing tumor recurrence after osteosarcoma surgery has consistently posed a clinical challenge. Local treatment with 3D-printed scaffolds loaded chemotherapeutic drugs can exert certain effects in inhibition and regeneration. However, the non-specific activation of leads to high local toxic side formation an immunosuppressive microenvironment, thereby limiting their application therapeutic efficacy. To address this, we designed Pt (IV) prodrug low toxicity minimal effects, which releases (II) response glutathione. This was grafted onto polydopamine (PDA) through amidation reaction, resulting composite nanomaterial (PDA@Pt) that possesses both photothermal synergistic chemotherapy immuno-oncological properties. Subsequently, innovatively employed selective laser sintering technology incorporate PDA@Pt into poly (L-lactic acid)/bioactive glass matrix, successfully constructing scaffold dual anti-tumor capabilities. The study revealed significantly inhibited growth cells activated cGAS-STING pathway by inducing DNA damage, ultimately converting 'cold tumor' 'hot tumor.' Additionally, could induce osteogenic differentiation marrow mesenchymal stem exhibited excellent capabilities vivo.

Language: Английский

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Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125640 - 125640

Published: April 1, 2025

Multiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, outcome regimens remains impaired by drugs' weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered development nanomaterials encapsulate deliver anticancer drugs. In fact, loading drugs into nanoparticles can overcome most solubility concerns. However, ability systemically administered drug-loaded reach site has vastly overestimated, limiting their clinical translation. The nanomaterials' administration issues propelled hydrogels capable performing direct/local delivery site. use these macroscale systems mediate a tumor-confined drugs/drugs-loaded grants an improved therapeutic efficacy and, simultaneously, reduction side effects. manufacture requires careful selection tailoring specific polymers/materials as well choice appropriate physical and/or chemical crosslinking interactions. Depending on route assembling process, matrices be classified injectable in situ forming hydrogels, shear-thinning/self-healing implantable each type bringing plethora advantages for intended biomedical application. This review provides reader with insight application nanomaterials.

Language: Английский

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m⁶A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract The transmembrane and coiled‐coil domains 3 (TMCO3) are highly expressed in many tumors. However, the underlying mechanisms governing way which TMCO3 affects progression of hepatocellular carcinoma (HCC) remain unclear. This study screens out molecule with high N6‐methyladenosine (m 6 A) modification level tumor samples compared to adjacent non‐cancerous tissues three pairs HCC patients through Methylated RNA Immunoprecipitation Sequencing (MeRIP‐seq) sequencing (RNA‐seq). Subsequently, oncogenic effect is verified vivo vitro experiments. AlkB Homolog 5 (ALKBH5), an m A demethylase then screened out. following experiments demonstrate that can activate AKT directly Phosphatidylinositol‐3–Kinase (PI3K) pathway, thus promoting HCC. Meanwhile, phosphorylation site on TMCO3: 85 th amino acid‐serine, mutation this impair activity membrane translocation found. Finally, carcinogenic further elucidated orthotopic treatment model hydrodynamic tail vein injection model. findings provide a potential target for targeted verify possible prognostic marker

Language: Английский

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Hypoxia-responsive albumin nanoparticles co-delivering banoxantrone and STING agonist enhance immunotherapy of high-intensity focused ultrasound

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113789 - 113789

Published: May 1, 2025

Language: Английский

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Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651

Published: Dec. 1, 2024

Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.

Language: Английский

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