Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Abstract
Polymicrobial
wound
infection
represents
a
significant
contributor
to
infectious
disease‐related
morbidity
and
mortality
globally.
Traditionally,
the
management
of
such
relies
heavily
on
high
doses
antibiotics,
often
resulting
in
systemic
side
effects
exacerbating
antibiotic
resistance.
Consequently,
there
is
an
urgent
need
develop
safe
effective
platform
for
antibiotic‐free
treatment
polymicrobial
infections.
In
this
study,
near‐infrared
(NIR)
light‐actuated
nanofibrous
membrane
incorporating
botanicals
nanozymes
presented
triple‐synergistic
therapy
against
The
integrates
berberine
hydrochloride
(BBH)‐loaded
hollow
zinc‐doped
carbon
nanocubes
into
polyvinyl
alcohol
(PVA)
membranes.
Upon
low‐intensity
808
nm
NIR
laser
irradiation
(0.3
W
cm
−2
),
achieved
controlled
release
BBH
enhanced
peroxidase‐like
(POD‐like)
enzyme
activity.
This
botanical/photothermal
(PTT)/chemodynamic
(CDT)
system
demonstrated
efficacy
eradicating
methicillin‐resistant
Staphylococcus
aureus
Pseudomonas
aeruginosa
both
vitro
vivo.
Furthermore,
it
mitigated
inflammation
promoted
healing
wounds,
highlighting
its
potential
as
promising
alternative
antibiotic‐based
therapies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(32)
Published: Jan. 21, 2024
Probiotics
with
diverse
and
crucial
properties
functions
have
attracted
broad
interest
from
many
researchers,
who
adopt
intestinal
delivery
of
probiotics
to
modulate
the
gut
microbiota.
However,
major
problems
faced
for
therapeutic
applications
are
viability
colonization
during
their
processing,
oral
intake,
subsequent
gut.
The
challenges
simple
(stability,
controllability,
targeting,
etc.)
greatly
limited
use
in
clinical
therapies.
Nanotechnology
can
endow
be
delivered
intestine
improved
survival
rate
increased
resistance
adverse
environment.
Additionally,
progress
synthetic
biology
has
created
new
opportunities
efficiently
purposefully
designing
manipulating
probiotics.
In
this
article,
a
brief
overview
types
delivery,
current
different
probiotic
encapsulation
strategies,
including
chemical,
physical,
genetic
strategies
combinations,
emerging
single-cell
using
nanocoating
methods,
is
presented.
action
mechanisms
that
responsible
eliciting
beneficial
effects
also
briefly
discussed.
Finally,
engineered
discussed,
future
trends
toward
developing
advanced
features
health
benefits
proposed.
Advanced Powder Materials,
Journal Year:
2024,
Volume and Issue:
3(4), P. 100191 - 100191
Published: March 18, 2024
Nanozymes,
a
category
of
nanomaterials
endowed
with
enzyme-mimicking
capabilities,
have
exhibited
considerable
potential
across
diverse
application
domains.
This
comprehensive
review
delves
into
the
intricacies
regulating
nanozymes
through
N
elements,
elucidating
mechanisms
governing
element
control
in
design
and
these
nanomaterials.
The
initial
sections
introduce
foundational
background
significance
nanozymes.
Subsequent
exploration
detailed
discussion
regulation
on
nanozymes,
encompassing
vacancies,
doping,
coordination,
nitride.
These
regulatory
pathways
play
an
instrumental
role
fine-tuning
catalytic
activity
specificity
further
scrutinizes
practical
applications
spanning
sensing
detection,
infection
therapy,
tumor
pollutant
degradation.
In
conclusion,
it
succinctly
summarizes
current
research
findings
proposes
future
directions
for
development.
thorough
investigation
by
elements
anticipates
precise
over
their
performance,
thereby
advancing
extensive
utilization
realms
biomedical
environmental
applications.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(38)
Published: July 26, 2024
Abstract
In
recent
years,
advancements
in
microbial
sequencing
technology
have
sparked
an
increasing
interest
the
bacteria
residing
within
solid
tumors
and
its
distribution
functions
various
tumors.
Intratumoral
critically
modulate
tumor
oncogenesis
development
through
DNA
damage
induction,
chronic
inflammation,
epigenetic
alterations,
metabolic
immune
regulation,
while
also
influencing
cancer
treatment
efficacy
by
affecting
drug
metabolism.
response
to
these
discoveries,
a
variety
of
anti‐cancer
therapies
targeting
microorganisms
emerged.
These
approaches
encompass
oncolytic
therapy
utilizing
tumor‐associated
bacteria,
design
biomaterials
based
on
intratumoral
use
bacterial
components
for
delivery
systems,
comprehensive
strategies
aimed
at
eradication
tumor‐promoting
bacteria.
Herein,
this
review
article
summarizes
patterns
different
tumors,
examines
their
impact
evaluates
current
therapeutic
centered
Furthermore,
challenges
prospects
developing
drugs
that
target
communities
are
explored,
promising
new
directions
treatment.
Medicine in Microecology,
Journal Year:
2024,
Volume and Issue:
22, P. 100111 - 100111
Published: Aug. 25, 2024
Probiotics
are
microbes
associated
with
a
wide
range
of
health
benefits
and
modulate
gut
flora
by
releasing
effector
molecules.
The
efficacy
probiotics
at
various
stages
cancer
treatment
has
been
well
demonstrated.
can
increase
the
potency
cancer-based
immunotherapy,
which
be
administered
before,
during,
or
post-phase
therapy.
consumption
among
patients
minimize
detrimental
effects
chemotherapy
act
as
potential
tool
for
Genetically
engineered
express
specific
antigens
that
combat
deadly
pathogens.
These
essential
features
utilized
in
other
applications.
This
review
aims
to
provide
updated
information
on
mechanism
action
their
applications
Moreover,
few
significant
like;
antioxidative
therapy,
biotechnology-based
improvement,
developing
potent
probiotic
strains
effective
also
discussed.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Polyphenol-functionalized
nanoarchitectures
(cytoPNAs)
provide
a
modular
and
cell
independent
strategy
to
create
biohybrids
for
engineering,
with
improved
production
biomanufacturing
enhanced
efficacy
cell-based
therapies.
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(8), P. 3289 - 3315
Published: Feb. 18, 2025
Inflammatory
bowel
disease
(IBD)
is
a
chronic
condition
affecting
the
intestines,
marked
by
immune-mediated
inflammation.
This
known
for
its
recurrent
nature
and
challenges
it
presents
in
treatment.
Recently,
probiotic
have
gained
attention
as
promising
alternative
to
traditional
small
molecular
drugs
monoclonal
antibody
chemotherapies
IBD.
Probiotic,
recognized
"living"
therapeutic
agent,
offers
targeted
treatment
with
minimal
side
effects
flexibility
biological
modifications,
making
them
highly
effective
IBD
management.
comprehensive
review
latest
advancements
engineering
probiotic-based
materials,
ranging
from
basic
mechanisms
modification
techniques
used
It
delves
deep
into
how
produces
intestinal
environment
discusses
various
strategies
enhance
probiotic's
efficacy,
including
genetic
modifications
formulation
improvements.
Additionally,
addresses
challenges,
practical
application
conditions,
future
research
directions
of
therapies
treatment,
providing
insights
their
feasibility
potential
clinical
implications.
BMC Plant Biology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 11, 2025
Tobacco
is
an
important
economic
crop
and
a
model
plant
for
molecular
biology
research.
It
exists
in
various
cultivars
processed
using
different
curing
methods.
Fatty
acids
play
crucial
role
the
quality
flavor
of
tobacco
leaves.
However,
there
limited
information
on
fatty
acid
composition
across
cultivars,
developmental
stages,
This
study
employed
targeted
metabolomics
transcriptomics
to
investigate
related
pathway
genes
leaves
from
focused
four
cultivars:
K326,
Basma,
Samsun,
Cuba1,
investigated
differences
at
stages
(seedling,
transplanting,
budding,
topping)
under
two
methods
(air-curing
flue-curing).
K326
was
used
as
main
cultivar
comparison
with
other
three.
The
analysis
included
short-chain
(C2-C6),
free
(C8-C24),
gene
expression
differences.
metabolic
profile
tissue
types
budding
stage
also
examined.
results
showed
significant
content
among
tissues
stage,
highest
levels
found
flower
buds
upper
At
seedling
were
marked
variations
periods.
Three
key
Nta01g31980,
Nta08g22780,
Nta23g11140
identified
major
differential
acid-related
pathways
compared
three
during
this
stage.
Regarding
total
ranked
Basma
>
Samsun
Cuba1
before
topping,
but
order
reversed
after
topping.
35
pathway-related
similar
differing
Cuba1.
Among
methods,
air-curing
resulted
higher
than
flue-curing.
Under
air-curing,
more
downregulation
while
opposite
observed
expands
our
understanding
providing
basis
their
biosynthesis
metabolism.
