Nano-armor modification of bacteria through supramolecular interactions for disease treatment DOI
Xinran Cao,

Yi Wang,

Qirui Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216165 - 216165

Published: Aug. 22, 2024

Language: Английский

Metal-Organic Frameworks in Biosensors DOI
Hilmiye Deniz Ertuğrul Uygun, Zihni Onur Uygun

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 287 - 314

Published: March 5, 2024

Biosensors have emerged as powerful analytical tools with applications wide range from healthcare diagnosis to environment detection. Metal-organic frameworks (MOFs) biosensing platforms has garnered significant attention for their superior specialties, such increased surface area, adaptable porosity, and excellent chemical thermal stability. This book chapter provides an overview of the recent advances in synthesis, characterization, MOFs biosensors. The also discusses challenges associated MOF integration, biocompatibility compatibility biological matrices, presents strategies overcome these hurdles. It delves into importance structural morphological analysis, functionalization, stability assessment optimize performance longevity MOF-based Moreover, it advanced techniques, spectroscopy, microscopy, electrochemical monitoring, used interaction biomolecules analyte highlights utilization biosensors analysis quantification biomarkers, toxins, heavy metals, pathogens, other analytes interest. Overall, this serves a comprehensive resource researchers, engineers, practitioners study/work on who seek explore potential advancing sensitivity, selectivity, versatility platforms. valuable insights design principles, fabrication characterization methods, biosensors, paving way development next-generation enhanced broad societal impact.

Language: Английский

Citations

2

Engineered Living Structures with Shape-Morphing Capability Enabled by 4D Printing with Functional Bacteria DOI
Shan Liu,

Muxuan Yang,

Cade Smarr

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 3247 - 3257

Published: April 22, 2024

Engineered living structures with the incorporation of functional bacteria have been explored extensively in recent years and shown promising potential applications biosensing, environmental remediation, biomedicine. However, it is still rare challenging to achieve multifunctional capabilities such as material production, shape transformation, sensing a single-engineered structure. In this study, we demonstrate bifunctional by synergistically integrating cellulose-generating pH-responsive hydrogels, entire can be precisely fabricated three-dimensional (3D) printing. Such 3D-printed produce cellulose nanofibers ambient conditions reversible controlled shape-morphing properties (usually referred four-dimensional printing). Those functionalities make them biomimetic versions silkworms sense that both generate body motion. We systematically investigate processing-structure-property relationship structures. The on-demand separation 3D from hydrogel template nature after processing transformation are also demonstrated.

Language: Английский

Citations

2

Lipid-Encapsulated Engineered Bacterial Living Materials Inhibit Cyclooxygenase II to Enhance Doxorubicin Toxicity DOI Creative Commons

Ning Jiang,

Wanqing Ding,

Xiaojuan Zhu

et al.

BioDesign Research, Journal Year: 2024, Volume and Issue: 6

Published: Jan. 1, 2024

Recently, there has been increasing interest in the use of bacteria for cancer therapy due to their ability selectively target tumor sites and inhibit growth. However, complexity interaction between cells evokes unpredictable therapeutic risk, which induces inflammation, stimulates up-regulation cyclooxygenase II (COX-2) protein, downstream antiapoptotic gene expression microenvironment reduce antitumor efficacy chemotherapy immunotherapy. In this study, we encapsulated celecoxib (CXB), a specific COX-2 inhibitor, liposomes anchored surface

Language: Английский

Citations

2

Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications DOI Creative Commons
Xia Lin, Rong Jiao, Haowen Cui

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 12, 2024

With the comprehensive understanding of microorganisms and rapid advances physiochemical engineering bioengineering technologies, scientists are advancing rationally-engineered bacteria as emerging drugs for treating various diseases in clinical disease management. Engineered specifically refer to advanced or genetic technologies combination with cutting edge nanotechnology physical which have been validated play significant roles lysing tumors, regulating immunity, influencing metabolic pathways, etc. However, there has no specific reviews that concurrently cover physiochemically- genetically-engineered their derivatives yet, let alone distinctive design principles functions applications. Herein, applications physiochemically bacteria, classify discuss breakthroughs an emphasis on methods objective different uses beyond cancer is described. The combined strategies developing vivo biotherapeutic agents based these bacterial derivatives, elucidated how they repress other also underlined. Additionally, challenges faced by translation future development directions discussed. This review expected provide overall impression enlighten more researchers.

Language: Английский

Citations

2

Nano-armor modification of bacteria through supramolecular interactions for disease treatment DOI
Xinran Cao,

Yi Wang,

Qirui Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216165 - 216165

Published: Aug. 22, 2024

Language: Английский

Citations

2