Oral
diseases
such
as
gingivitis
and
periodontitis
represent
signi
cant
global
health
challenges,
a
ecting
substantial
portion
of
the
population.These
conditions,
driven
by
bacterial
bio
lms,
can
cause
severe
damage
to
tooth-supporting
tissues,
leading
tooth
loss
impacting
overall
well-being.Traditional
oral
antibiotics
face
limitations,
including
broad-spectrum
side
e
ects
insu
cient
concentration
at
infection
sites,
often
resulting
in
antimicrobial
resistance.This
mini-review
explores
potential
nanobots
for
targeted
drug
delivery
treating
infections.Nanobots,
ranging
from
1
100
nanometers,
navigate
cavity,
directly
targeting
lms
releasing
agents
controlled
manner.This
approach
enhances
reduces
systemic
ects,
minimizes
resistance
development.Various
types
nanobots,
dentifrobots
pharmacytes,
are
discussed
their
roles
healthcare.Recent
advancements
demonstrate
cacy
vitro
vivo,
highlighting
ability
eradicate
deliver
drugs
precisely.However,
challenges
biocompatibility,
stability,
regulatory
hurdles
must
be
addressed
clinical
application.Future
directions
include
integrating
multifunctional
capabilities
simultaneous
treatment
tissue
repair,
real-time
monitoring
through
advanced
imaging
biosensing,
personalized
therapies
tailored
individual
microbiomes.By
overcoming
these
have
revolutionize
healthcare,
o
ering
innovative
solutions
ectively
manage
treat
infections,
ultimately
improving
patient
outcomes
health.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
With
the
global
population
aging,
awareness
of
oral
health
is
rising.
Periodontitis,
a
widespread
bacterial
infectious
disease,
gaining
attention.
Current
novel
biomaterials
address
key
clinical
issues
like
infection,
gum
inflammation,
tooth
loosening,
and
loss,
focusing
on
antibacterial,
anti-inflammatory,
tissue
regeneration
properties.
However,
strategies
that
integrate
advantages
these
to
achieve
synergistic
therapeutic
effects
by
clearing
biofilms,
inhibiting
inflammation
activation,
restoring
periodontal
soft
hard
functions
remain
very
limited.
Recent
studies
highlight
link
between
periodontitis
systemic
diseases,
underscoring
complexity
disease.
There
an
urgent
need
find
comprehensive
treatment
plans
requirements.
Whether
integrating
new
enhance
existing
treatments
or
developing
approaches
replace
traditional
therapies,
efforts
will
drive
advancements
in
treatment.
Therefore,
this
review
compares
with
treatments.
It
highlights
design
concepts
mechanisms
functional
materials,
their
properties,
discusses
importance
strategies.
This
aims
provide
guidance
for
emerging
research
promote
development
precise
efficient
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: March 5, 2025
Periodontitis
is
a
chronic
inflammatory
disease
induced
by
the
microbiome,
leading
to
destruction
of
periodontal
structures
and
potentially
resulting
in
tooth
loss.
Using
local
drug
delivery
systems
as
an
adjunctive
therapy
scaling
root
planning
periodontitis
promising
strategy.
However,
this
administration
method's
effectiveness
constrained
complexity
environment.
Nanomaterials
have
demonstrated
significant
potential
antibacterial
treatment
periodontitis,
attributed
their
controllable
size,
shape,
surface
charge,
high
design
flexibility,
reactivity,
specific
area.
In
review,
we
summarize
complex
microenvironment
difficulties
explicitly
reviewing
application
strategies
nanomaterials
with
unique
properties
distinct
periodontitis.
Furthermore,
review
discusses
limitations
current
research,
proposes
feasible
solutions,
explores
prospects
for
using
context.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2025,
Volume and Issue:
24(3)
Published: April 22, 2025
Abstract
Biofilm
formation
on
dairy
equipment
is
a
persistent
challenge
in
the
industry,
contributing
to
product
contamination,
inefficiency,
and
economic
losses.
Traditional
methods
such
as
manual
cleaning
basic
chemical
sanitation
are
discussed
foundational
approaches,
followed
by
an
in‐depth
investigation
of
cutting‐edge
technologies,
including
clean‐in‐place
systems,
high‐pressure
cleaning,
foam
ultrasonic
electrochemical
dry
ice
blasting,
robotics,
nanotechnology‐based
agents,
enzymatic
cleaners,
oxidizing
agents.
Enhanced
techniques,
steam,
pulsed
light,
acidic
alkaline
electrolyzed
water,
hydrogen
peroxide
vapor,
microbubble
technology,
biodegradable
biocides,
highlighted
for
their
potential
achieve
superior
while
promoting
sustainability.
The
effectiveness,
feasibility,
limitations
these
evaluated,
emphasizing
role
maintaining
hygiene
reducing
biofilm‐associated
risks.
Additionally,
challenges,
compatibility,
cost,
regulatory
compliance,
addressed,
along
with
insights
into
future
directions
innovations,
automation,
smart
green
solutions.
This
review
provides
comprehensive
resource
researchers,
industry
professionals,
policymakers
aiming
tackle
biofilm
production
systems
enhance
food
safety,
operational
efficiency,
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 24, 2024
In
the
context
of
an
increasingly
escalating
antibiotics
crisis,
phototherapy
has
emerged
as
a
promising
therapeutic
approach
due
to
its
inherent
advantages,
including
high
selectivity,
noninvasiveness,
and
low
drug
resistance.
Photothermal
therapy
(PTT)
photodynamic
(PDT)
are
two
complementary
phototherapies
albeit
with
limitations,
noted
challenges
in
achieving
precise
heat
confinement
associated
risk
off-target
damage
for
PTT,
while
constraints
hypoxic
microenvironment
prevalent
biofilms
faced
by
PDT.
Herein,
we
have
designed
supramolecular
nanoformulation
that
leverages
complexation-induced
quenching
guanidinium-modified
calix[5]arene
grafted
fluorocarbon
chains
(GC5AF
