Neutrophil Function Conversion Driven by Immune Switchpoint Regulator against Diabetes‐Related Biofilm Infections

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Dec. 1, 2023

Abstract Reinforced biofilm structures and dysfunctional neutrophils induced by excessive oxidative stress contribute to the refractoriness of diabetes‐related infections (DRBIs). Herein, in contrast traditional antibacterial therapies, an immune switchpoint‐driven neutrophil function conversion strategy based on a deoxyribonuclease I loaded vanadium carbide MXene (DNase‐I@V 2 C) nanoregulator is proposed treat DRBIs via lysis redirecting functions from NETosis phagocytosis diabetes. Owing its intrinsic superoxide dismutase/catalase‐like activities, DNase‐I@V C effectively scavenges reactive oxygen species (ROS) high microenvironment maintain biological activity DNase‐I. By increasing depth penetration DNase‐I, thoroughly degrades extracellular DNA traps (NETs) polymeric substances, thus breaking physical barrier biofilms. More importantly, as switchpoint regulator, can skew toward intercepting ROS–NE/MPO–PAD4 activating ROS–PI3K–AKT–mTOR pathways diabetic microenvironment, thereby eliminating infections. Biofilm synergistic exert favorable therapeutic effects vitro vivo. This study serves proof‐of‐principle demonstration achieving with efficacy regulating reverse functions.

Language: Английский

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BioHJzyme-Armed Hydrogel for Infectious Wound Monitoring Through Enzyme-Mimetic Antibacterial Activities and Macrophage Regulation

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151005 - 151005

Published: April 4, 2024

Language: Английский

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Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

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Inorganic-Nanomaterial-Composited Hydrogel Dressings for Wound Healing

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(2), P. 46 - 46

Published: Jan. 26, 2024

Wound management heavily relies on the vital contribution of wound dressings, emphasizing significance finding an ideal dressing that can fulfill intricate requirements healing process with multiple functions. A promising strategy is combining several materials and therapies to create multifunctional dressings. Nanocomposite hydrogel dressings based nanomaterials, advantages nanomaterials hydrogels in treatment, significantly improve their respective performance compensate for shortcomings. variety nanocomposite diverse structures synergistic functions have been developed recent years, achieving results applications. In this review, functions, advantages, limitations as are first discussed. Additionally, application inorganic also elaborated on. Furthermore, we focused summarizing analyzing healing, which contain various including metals, metal oxides, sulfides, carbon-based silicon-based nanoparticles. Finally, prospects envisaged, providing insights further research management.

Language: Английский

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward

Language: Английский

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Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In recent years, the use of MXenes, a class two-dimensional materials composed transition metal carbides, nitrides, or carbonitrides, has shown significant promise in field skin wound healing. This review explores multifunctional properties focusing on their electrical conductivity, photothermal effects, and biocompatibility this field. MXenes have been utilized to develop advanced healing devices such as hydrogels, patches, smart bandages for examination. These offer enhanced antibacterial activity, promote tissue regeneration, provide real-time monitoring parameters. The highlights synthesis methods, chemical features, biological effects emphasizing role innovative repair strategies. Additionally, it discusses potential MXene-based sensors humidity, pH, temperature monitoring, which are crucial preventing infections complications integration into wearable represents advancement management, promising improved clinical outcomes quality life patients.

Language: Английский

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Electron Orbital Hybridization‐Enhanced Copper‐Nanocatalysis for Anti‐Infection

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Jan. 23, 2024

Abstract Recurrent bacterial infections, impenetrable microbial biofilms, and irremediable antibiotic resistance are the most perilous threats in orthopedic implant‐associated infections (IAIs). Recently, chemodynamic therapy (CDT) has been considered a promising therapy, while clinical practices for existing CDT agents limited by low therapeutic efficiency physiological circumstances. Herein, it is demonstrated that silica‐copper nanosheets (Si@Cu NSs) exhibit combined photothermal‐chemodynamic strategy IAIs treatment with superior capacity biocompatibility. This unique design endows nanostructure enhanced copper‐based Fenton‐like properties via p‐d orbital hybridization incorporating copper nanoclusters (Cu NCs) on silicene (Si matrix, integrating inherent photothermal performance of Si NSs specific catalytic anti‐infection Cu NCs against planktonic bacteria biofilms both vitro vivo. study not only reveals bio‐application prospects 2D nanocatalytic biomaterials but also demonstrates feasibility constructing novel IAIs.

Language: Английский

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Biomimetic multilayer scaffolds with prolonged retention of stem cells-recruiting and angiogenic peptides for promoting bladder regeneration

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 277, P. 111409 - 111409

Published: March 21, 2024

Language: Английский

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Low‐Intensity Ultrasound‐Activated Cavitation Effect Triggers Piezoelectric Catalysis Coordinating Respiratory Chain Interference Tactics Against Bacterial Infection

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Piezocatalytic therapy has aroused considerable attention in the treatment of bacterial infection due to its noninvasive and deep tissue penetration capabilities. The catalytic efficiency, however, is significantly constrained by insufficient piezoresponse sonosensitizers at low‐intensity ultrasound (LIU) accompanied poor separation efficiency charges, resulting unsatisfactory sterilization. To address dilemma, a piezocatalytic bio‐heterojunction (P‐bioHJ) consisting BiOI few‐layered Mxene constructed for rapid antibacterial. engineered P‐bioHJ not merely possesses relatively narrow‐bandgap responding sonoluminescence emitted sonocavitation effect, but rather induces interfacial polarization generation oxygen vacancies facilitate effective carriers, leading burst radicals Transcriptomic analysis reveals that instigates sterilization interfering with electron transport chain, disrupting both metabolism energy synthesis. In vitro experiments indicate excellent cytocompatibility P‐bioHJ. Furthermore, vivo assays demonstrate exhibits outstanding antimicrobial properties cutaneous model LIU, promotes angiogenesis osteogenesis an infectious bone defect decorating naringin. As envisaged, this work offers valuable insight augment harnessing advancing remediation infected regeneration.

Language: Английский

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Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Senescent bone tissue displays a pathological imbalance characterized by decreased angiogenesis, disrupted bioelectric signaling, ion dysregulation, and reduced stem cell differentiation. Once defects occur, this makes them difficult to repair. An innovative synergistic therapeutic strategy is utilized reverse these imbalances via conductive hydrogel doped with magnesium (Mg 2+ )‐modified black phosphorus (BP). The reprograms electrical signals, restores Mg homeostasis, reconstructs physiological promotes blood vessel regeneration in senile defects. synergistically both the chemical signals within microenvironment. This increases expression of vascular endothelial growth factor (VEGF) VEGF receptor‐2 (VEGFR2), activates PI3K‐AKT‐eNOS pathway, significantly angiogenic ability cells aged state. In addition, normalizes calcium (Ca ) influx, accumulation osteogenic transcription factors nucleus, differentiation senescent cells. treatment bone‐vascular coupling areas defects, achieves effective vascularized regeneration, has good potential for

Language: Английский

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