Diabetic Microenvironment‐Unlocked BioHJzyme with H2S Evolution for Robust Anti‐Pathogens and Hyperinflammatory Wound Regeneration Through TGF‐β/Smad Pathway DOI
Xiangyu Gao, Miaomiao He,

Wanxi Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: Sept. 30, 2024

Abstract Deferred diabetic skin healing is an ever‐growing complication owing to the hyperglycemic microenvironment, which accelerates generation of advanced glycated end products (AGEs) and provides a hotbed for pathogenic infection. Here, H 2 S‐evolving bio‐heterojunction enzyme (BioHJzyme), consisted by MXene/FeS glucose oxidase (GOx) devised. It presents glutathione peroxidase (GPx)‐ (POD)‐mimetic antibacterial activity anti‐pathogens wound regeneration AGEs depression. The GOx catalyzes glucose, resulting in reducing bacterial nutrient supplying O . POD‐mimetic BioHJzyme hydroxyl radical (•OH) with turnover number 4.45 × 10 −1 s , while GPx‐mimetic it consumes further •OH accumulation. can be enhanced near infrared laser (NIR) irradiation efficient separation electron‐hole pairs originated from heterostructure, NIR‐activatable 1 production. Moreover, evolves S acidic environment, acting as donor, protects cells around oxidative damage AGEs, rescues mitochondrial respiration, improves extracellular matrix deposition ameliorates dysfunction fibroblasts through TGF‐β/Smad pathway. work proof‐of‐concept bacteria‐invaded via BioHJzyme.

Language: Английский

Type‐Transformational BioHJzyme Enabled by Composition Modulation‐Mediated Energy Band Engineering for Diabetic Infectious Wound Healing DOI Open Access
Miaomiao He,

Zuyao Wang,

Dan Sun

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The dilemma of diabetic infectious wound healing lies in inhibiting the pathogenic colonization and regulating hyperglycemia. pivotal anti‐pathogenic efficiency is focused on confined gradually weaken reactive oxygen species (ROS) yield peculiar micromilieu owing to materials transformation/dissolution. There, type‐transformational bio‐heterojunction enzyme (BioHJzyme) with operando composition‐modulation proposed, which consisted by glucose oxidase (GOx) decorated type‐I FeSe 2 /Cu O heterojunction. It exhibits robust catalytic produce ROS. Followed, heterojunction can be transformed into dual Z‐scheme a composition /CuSe/Cu primed acid meliorative energy band. conducive NIR‐induced capabilities improve ROS yield. GOx consume H as an amplifier. combined followed enhanced powerfully remove colonization. On top that, sample downgrade Forkhead box (FoxO) signaling pathway regulate cell cycle, facilitate proliferation, further promote repairment. This work provides effective feasible antibacterial strategy way thinking for healing.

Language: Английский

Citations

2
A H₂S‐Evolving Alternately‐Catalytic Enzyme Bio‐Heterojunction with Antibacterial and Macrophage‐Reprogramming Activity for All‐Stage Infectious Wound Regeneration DOI
Miaomiao He,

Zuyao Wang,

Danni Xiang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 29, 2024

The disorder of the macrophage phenotype and hostile by-product lactate evoked by pathogenic infection in hypoxic deep wound inevitably lead to stagnant skin regeneration. In this study, hydrogen sulfide (H

Language: Английский

Citations

12
MXene-reinforced bioactive polymer hydrogels for biomedical applications DOI Creative Commons

Guanghui Gu,

Xue Chen, Gang Wei

et al.

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced

Language: Английский

Citations

4
Recent Advances in Biomedical Applications of MXene‐Integrated Electrospun Fibers: A Review DOI
Ali Hamzehlouy,

Sara Zarei,

Razhan Salah Othman

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The integration of MXenes into electrospun fibers represents a significant leap forward in advancing biomedical applications. This review delves the synergistic combination and fibers, highlighting their multifaceted capabilities tissue engineering, drug delivery, antimicrobial activity, cancer therapy, biosensing. Exceptional properties MXene, including electrical conductivity, hydrophilicity, mechanical robustness, surface tunability, offer unique advantages when incorporated nanofibrous scaffolds. By enhancing strength, promoting cellular interactions, enabling targeted therapeutic functions, MXene‐based demonstrate immense potential addressing critical challenges biomedicine. provides comprehensive overview recent advances MXene synthesis, incorporation matrices, applications, while also identifying future directions this emerging field.

Language: Английский

Citations

0
A sustained H2S-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing DOI

Shuhan Zhao,

Wei Zhao, Nan Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123424 - 123424

Published: Feb. 20, 2025

Language: Английский

Citations

0
ROS‐Modulating Bio‐Heterojunction Nanosheets for Infected Wound Healing via Nanozyme Activity DOI

Fei-Hu Cui,

Wenjun Fu, Qing Chang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Reactive oxygen species (ROS) play a pivotal role in wound healing due to their ability eradicate bacterial infections. However, excessive ROS can induce oxidative stress and prolonged inflammation, which significantly hinder the wound‐healing process. To address this challenge, Ti 3 C 2 T x ‐Se NPs (TS) heterojunction nanosheets, are developed enhance electron transfer under near‐infrared (NIR) laser irradiation confirmed by ultraviolet photoelectron spectroscopy (UPS) analysis. Compared , TS exhibits superior antibacterial activity against S. aureus E. coli through synergistic mechanisms of chemical dynamic therapy (CDT) photothermal (PTT). In absence treatment, demonstrates “ROS modulating effect”, effectively scavenging catalase (CAT) superoxide dismutase (SOD) activities. efficiently eliminated hydroxyl radicals (90.87%), anion (76.33%), hydrogen peroxide (95.72%) at low concentration, thereby minimizing damage. vivo studies further reveal that reduces damage, clears infections, promotes angiogenesis, accelerating healing. offers precise regulation while leveraging effects PTT CDT. This material not only potent properties but also alleviates accumulation, mitigates fosters tissue regeneration, making it promising candidate for treatment infectious wounds.

Language: Английский

Citations

0
Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection DOI
Miaomiao He,

Xuyang Yang,

Danni Xiang

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Abundant ·OH, 1O2, and ·O2- provide an efficient methodology for rapid tumor bacteria killing, whereas a limitation focuses on the catalytic efficiency. Thus, Jahn-Teller-driven electronic modulation of bioheterojunction (bioHJ) platform is developed remedy in diabetic infectious wound regeneration after postoperative resection. The bioHJ composed MoTe2/MnO2 glucose oxidase (GOx). GOx depletes to H2O2, which intercepts their metabolism. H2O2 can be further converted into highly lethal ·OH owing peroxidase-mimetic activity via Jahn-Teller effect, while GSH consumed due its GPx-mimetic activity. Both amplified upon NIR irradiation as NIR-activatable enzyme-mimetic activities. In vivo studies subcutaneous model authenticate ability kill tumor, defeat bacterial infection, accelerate regeneration. This work enlightens powerful resection using engineered bioHJ.

Language: Английский

Citations

0
Diabetic Microenvironment‐Unlocked BioHJzyme with H2S Evolution for Robust Anti‐Pathogens and Hyperinflammatory Wound Regeneration Through TGF‐β/Smad Pathway DOI
Xiangyu Gao, Miaomiao He,

Wanxi Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: Sept. 30, 2024

Abstract Deferred diabetic skin healing is an ever‐growing complication owing to the hyperglycemic microenvironment, which accelerates generation of advanced glycated end products (AGEs) and provides a hotbed for pathogenic infection. Here, H 2 S‐evolving bio‐heterojunction enzyme (BioHJzyme), consisted by MXene/FeS glucose oxidase (GOx) devised. It presents glutathione peroxidase (GPx)‐ (POD)‐mimetic antibacterial activity anti‐pathogens wound regeneration AGEs depression. The GOx catalyzes glucose, resulting in reducing bacterial nutrient supplying O . POD‐mimetic BioHJzyme hydroxyl radical (•OH) with turnover number 4.45 × 10 −1 s , while GPx‐mimetic it consumes further •OH accumulation. can be enhanced near infrared laser (NIR) irradiation efficient separation electron‐hole pairs originated from heterostructure, NIR‐activatable 1 production. Moreover, evolves S acidic environment, acting as donor, protects cells around oxidative damage AGEs, rescues mitochondrial respiration, improves extracellular matrix deposition ameliorates dysfunction fibroblasts through TGF‐β/Smad pathway. work proof‐of‐concept bacteria‐invaded via BioHJzyme.

Language: Английский

Citations

3