Designing hydrogel for application in spinal surgery

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101536 - 101536

Published: Feb. 3, 2025

Language: Английский

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Harnessing Mn²⁺ Ions and Antitumor Peptides: A Robust Hydrogel for Enhanced Tumor Immunotherapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Immunotherapy has attracted widespread attention because of its durable and effective antitumor properties. However, systemic delivery strategies often result in immune-related off-target toxicity effects inadequate drug retention at the tumor site, which limits broader application. In this research, we designed a dual-functional peptide (N-Pep) that serves as both therapeutic agent metal ions (Mn2+) immunomodulator carrier. The rational self-assembles into hydrogel through coordination with Mn2+ (referred to N-Pep-Mn gel). multiporous network allows for efficient loading antiprogrammed death-1 antibody (αPD-1). served depot sustained release encapsulated αPD-1, effectively activating dendritic cells, polarizing tumor-associated macrophages enhancing effector T cell infiltration, thereby leading inhibition growth intratumoral immune responses. Additionally, induces robust memory, providing substantial protection against recurrence. These findings underscore potential ion-coordinated an advanced platform immunotherapy.

Language: Английский

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Continuous mechanical-gradient hydrogel with on-demand distributed Mn2+/Mg-doped hydroxyapatite@Fe3O4 for functional osteochondral regeneration

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 608 - 626

Published: March 29, 2025

Language: Английский

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Orally-Deliverable Liposome-Microgel Complexes Dynamically Remodel Intestinal Environment to Enhance Probiotic Ulcerative Colitis Therapy via TLR4 Inhibition and Tryptophan Metabolic Crosstalk

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123339 - 123339

Published: April 1, 2025

Language: Английский

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Current Utilization of Gel-Based Scaffolds and Templates in Foot and Ankle Surgery—A Review

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 316 - 316

Published: April 24, 2025

As tissue engineering and regenerative medicine (TERM) continues to revolutionize surgery, there is also growing interest in applying these advancements foot ankle surgery. The purpose of this article provide a comprehensive review the types gel scaffolds templates, their applications challenges with current utilization, future directions TERM With multiple compelling scaffold prospects across numerous natural, synthetic, hybrid polymers currently utilized TERM, promising results have been described treatment osteoarthritis (OA) osteochondral lesions (OCLs). However, concerns material biocompatibility, structural integrity, feasibility during degradation still exist limit extent utilization. researchers continue develop enhanced formulations that address issues, are many opportunities increase

Language: Английский

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Engineering Hydrogel-Based Composites for Photoluminescent Biomaterials

Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 231 - 257

Published: Jan. 1, 2025

Language: Английский

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Advanced Hydrogels in Breast Cancer Therapy

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 479 - 479

Published: July 19, 2024

Breast cancer is the most common malignancy among women and second leading cause of cancer-related death for women. Depending on tumor grade stage, breast primarily treated with surgery antineoplastic therapy. Direct or indirect side effects, emotional trauma, unpredictable outcomes accompany these traditional therapies, calling therapies that could improve overall treatment recovery experiences patients. Hydrogels, biomimetic materials 3D network structures, have shown great promise augmenting Hydrogel implants can be made adipogenic angiogenic properties tissue integration. organoids malignant tumors grown in hydrogels retain physical genetic characteristics native tumors, allowing post-surgery recapitulation diseased tissues precision medicine assessment responsiveness patient-specific cancers to treatment. Hydrogels also used as carrier matrices delivering chemotherapeutics immunotherapeutics prosthetic scaffolds. The hydrogel delivery systems achieve localized controlled medication release targeting site, enhancing efficacy minimizing adverse effects therapeutic agents delivered by procedures. This review aims summarize recent advancements utilization reconstruction, modeling, therapy discuss their limitations clinical translation.

Language: Английский

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An immunotherapeutic hydrogel booster inhibits tumor recurrence and promotes wound healing for postoperative management of melanoma

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 178 - 193

Published: Aug. 31, 2024

Low tumor immunogenicity, immunosuppressive microenvironment, and bacterial infections have emerged as significant challenges in postsurgical immunotherapy skin regeneration for preventing melanoma recurrence. Herein, an immunotherapeutic hydrogel booster (GelMA-CJCNPs) was developed to prevent postoperative recurrence promote wound healing by incorporating ternary carrier-free nanoparticles (CJCNPs) containing chlorine e6 (Ce6), a BRD4 inhibitor (JQ1), glutaminase (C968) into methacrylic anhydride-modified gelatin (GelMA) dressings. GelMA-CJCNPs reduced glutathione production inhibiting glutamine metabolism, thereby the destruction of reactive oxygen species generated photodynamic therapy, which could amplify oxidative stress induce severe cell death enhance immunogenic death. In addition, M2-type tumor-associated macrophage polarization blocking metabolism reverse recruiting more tumor-infiltrating T lymphocytes. also downregulated IFN-γ-induced expression programmed ligand 1 mitigate acquired immune resistance. Benefiting from amplified systemic antitumor immunity, markedly inhibited growth both primary distant tumors. Moreover, demonstrated satisfactory antibacterial effects against

Language: Английский

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Integration of two-dimensional MXene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent Advances and Future Prospects

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113512 - 113512

Published: Oct. 1, 2024

Language: Английский

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Hybrid Hydrogel with Photothermal Stimulation Elicits Immunomodulation‐Mediated Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract It is of paramount importance to maintain the thermal environment wounds in order facilitate optimal tissue repair and regeneration. Nevertheless, their potential as a hyperthermia regenerative therapy remains be fully elucidated. In this study, photothermal hybrid hydrogel constructed through simple “one‐step” activation process that elicits mild stimulation presented, thereby providing stable cycling capability activating immune response, accelerating restoration redox homeostasis, ultimately promoting wound healing. The results demonstrate application HGBM an impaired healing model, which exhibited elevated levels reactive oxygen species, enhanced responses, promotion macrophage polarization M2/M1, inducing pro‐regenerative response. RNA‐sequencing data at 45 °C enhances response respiratory burst process, regulating microenvironment injured tissues. Furthermore, transition from inflammatory state anti‐inflammatory pro‐healing state, promoted by production factors such interleukin‐10 interleukin‐4. This work therefore provides effective strategy for context skin

Language: Английский

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