Nanotherapeutics to cure inflammation-induced cancer DOI Open Access
Rajiv Kumar

Current Cancer Reports, Journal Year: 2024, Volume and Issue: 6(1), P. 193 - 204

Published: July 2, 2024

Aims: Nanotherapeutics are being explored as a potential solution to treat inflammation-induced cancer. enhance innate immune cells' immunity, enabling them fight tumors effectively. These cells secrete specific chemicals like cytokines, allowing replicate quickly and respond future threats, making suitable for immunotherapy.Methods: Nanotechnology can significantly improve human health by enhancing infection detection, prevention, treatment. Nanomedicines, composed of restorative imaging compounds in submicrometer-sized materials, aim deliver effective treatments limit inflammation healthy body areas. Combining nanotechnology clinical sciences, nanoparticles gene therapy have been developed treating various diseases, including cancer, cardiovascular, diabetes, pulmonary, inflammatory diseases.Results: Neutrophils their offspring, films extracellular vehicles, crucial drug transporters enhanced growth therapy. Tumor microenvironment inputs modify tumor-associated neutrophils (TANs), which essential tumor healing. Human intratumor heterogeneity is Nanomedicines shown targeted delivery, toxicity reduction, therapeutic effectiveness enhancement. However, relevance efficacy remain inadequate due lack understanding the interaction between nanomaterials, nanomedicine, biology. The diverse biological milieu impacts dynamic bioidentity nanoformulations, interactions function or cellular absorption.Conclusion: holds great promise improving detecting, preventing, infections. fusion sciences nanotechnology, use transporter materials delivery reducing contamination. Nanoparticles' small size high surface-to-volume ratio benefit Research has led wide range nanomedicine products globally.

Language: Английский

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease DOI Creative Commons

Weifeng He,

Lingfeng Yan,

Dongxue Hu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Jan. 21, 2025

Abstract Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity plasticity, challenging traditional view of neutrophils a homogeneous population with limited functional repertoire. Advances single‐cell technologies assays revealed distinct neutrophil subsets diverse phenotypes functions ability to adapt microenvironmental cues. This review provides comprehensive overview multidimensional landscape heterogeneity, discussing various axes along which diversity manifests, including maturation state, density, surface marker expression, polarization. We highlight molecular mechanisms underpinning focusing on complex interplay signaling pathways, transcriptional regulators, epigenetic modifications that shape responses. Furthermore, we explore implications plasticity physiological processes pathological conditions, host defense, inflammation, tissue repair, cancer. By integrating insights from cutting‐edge research, this aims provide framework for understanding multifaceted roles potential therapeutic targets wide range diseases.

Language: Английский

Citations

3
Bidirectional role of neutrophils in tumor development DOI Creative Commons

Haoxin Luyang,

Feng Zeng, Lei Yan

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 16, 2025

Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable research interest due to their dual roles in both promoting and inhibiting tumor progression. This paper seeks clarify specific mechanisms by which neutrophils play a bidirectional role immunity factors that influence these roles. By conducting comprehensive analysis synthesis vast array relevant literature, it has become evident can development invasive migration through various mechanisms, thereby exerting anti-tumor effects. Conversely, they also facilitate tumorigenesis proliferation, well affect normal physiological functions other cells, thus pro-tumor Moreover, are influenced cells unique microenvironment, turn affects heterogeneity plasticity. Neutrophils interact with regulate aspects life activities precisely. identifies unresolved issues concerning development, offering new opportunities challenges for advancing our understanding. This, turn, aid proper application insights clinical treatment strategies.

Language: Английский

Citations

2
Adaptations of neutrophils in cancer DOI
Melissa Ng, Daniela Cerezo‐Wallis, Lai Guan Ng

et al.

Immunity, Journal Year: 2025, Volume and Issue: 58(1), P. 40 - 58

Published: Jan. 1, 2025

Language: Английский

Citations

1
Neutrophil Engulfment in Cancer: Friend or Foe? DOI Open Access

Tong Lu,

Wei Li

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 384 - 384

Published: Jan. 24, 2025

Neutrophils, the most abundant circulating white blood cells, are essential for initial immune response to infection and injury. Emerging research reveals a dualistic function of neutrophils in cancer, where they can promote or inhibit tumor progression. This dichotomy is influenced by microenvironment, with capable remodeling extracellular matrix, promoting angiogenesis, alternatively inducing cancer cell death enhancing responses. An intriguing yet poorly understood aspect neutrophil–cancer interactions phenomenon neutrophil engulfment which has been observed across various cancers. process, potentially mediated LC3-associated phagocytosis (LAP), raises questions about whether it serves as mechanism evasion contributes through pathways like ferroptosis. review examines current knowledge on development, their roles mechanisms LAP cells. We discuss how manipulating impacts progression may represent therapeutic strategy. also explore neutrophils’ potential delivery vehicles agents. Understanding complex functions tumor-associated (TANs) molecular underlying open new avenues effective interventions mitigate risks.

Language: Английский

Citations

1
Distinct Immunophenotypic Profiles and Neutrophil Heterogeneity in Colorectal Cancer DOI

Minghua Bai,

Yuzhao Jin,

Zihao Jin

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 616, P. 217570 - 217570

Published: Feb. 22, 2025

Language: Английский

Citations

1
Are monocytes a preferable option to develop myeloid cell-based therapies for solid tumors? DOI Creative Commons

Daisy Bhatia,

Riccardo Dolcetti, Roberta Mazzieri

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: March 15, 2025

Abstract In the last two decades, novel and promising cell-based therapies have populated treatment landscape for haematological tumors. However, commonly exploited T NK show limited applicability to solid This is mainly given by impaired tumor trafficking capability effector activity of these cells within a highly immunosuppressive microenvironment. Myeloid spontaneously home tumors can thus be reprogrammed and/or engineered directly attack or locally selectively deliver therapeutically relevant payloads that may improve efficacy immunotherapy against difficult-to-access context myeloid therapies, adoptive transfer monocytes has often been overshadowed infusion differentiated macrophages hematopoietic stem cell transplantation despite their therapeutic potential. Here, we summarize recent improvements benefits using tumors, current clinical applications challenges use as well some possible strategies overcome them.

Language: Английский

Citations

1
Turning cold into hot: emerging strategies to fire up the tumor microenvironment DOI
Kejing Ma, Lin Wang, Wenhui Li

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

5
Controlled Inflammation Drives Neutrophil‐Mediated Precision Drug Delivery in Heterogeneous Tumors DOI Creative Commons
Yunfei Guo, Yiming Li, Jianmin Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Tumor heterogeneity remains a formidable obstacle in targeted cancer therapy, often leading to suboptimal treatment outcomes. This study presents an innovative approach that harnesses controlled inflammation guide neutrophil‐mediated drug delivery, effectively overcoming the limitations imposed by tumor heterogeneity. By inducing localized within tumors using lipopolysaccharide, it significantly amplify recruitment of drug‐laden neutrophils sites, irrespective specific markers. strategy not only enhances delivery but also triggers release neutrophil extracellular traps, further potentiating anti‐tumor effect. Crucially, this demonstrates potential systemic inflammatory responses can be mitigated through transfusion, ensuring safety and clinical viability approach. In murine breast model, method impedes growth compared conventional treatments. work offers versatile for precise across diverse types. The findings pave way more effective broadly applicable treatments, potentially addressing long‐standing challenge

Language: Английский

Citations

0
A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy DOI Open Access
Garima Sharma,

Kwanjira Wangpimool,

Jomon George Joy

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Immune cells show enormous potential for targeted nanoparticle delivery due to their intrinsic tumor-homing skills. However, the immune can internalize nanoparticles, leading cellular functional impairments, degradation of and delayed release drugs from cells. To address these issues, this study introduces an approach synthesis freshly derived neutrophils (NUs)-based nanocarriers system where NUs are surfaced by dialdehyde alginate-coated self-assembled micelles loaded with mitoxantrone (MIT) indocyanine green (ICG) (i.e., dA(MI@IPM)s) stimuli-responsive tumor-targeted therapy. Here, dA(MI@IPM)s not internalized NUs, but they anchored on membrane via distearoylphosphatidylethanolamine-polyethylene glycol-polyethylenimine anchors. Owing natural recruitment ability tumor microenvironment, NUs-anchored accumulation is higher at site than free dA(MI@IPM)s, readily detach get in The disassembles inside cancer upon near-infrared irradiation photosensitizing effect ICG, releasing MIT significantly inhibiting growth. This simple fast prepare, opening up exciting possibilities personalized treatment using patient's autologous NUs.

Language: Английский

Citations

0