BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 12, 2025
Abstract
Background
Osteosarcoma
is
a
rare
tumor
with
poor
clinical
outcomes.
New
therapeutic
targets
are
urgently
needed.
Previous
research
indicates
that
genes
abnormally
expressed
in
osteosarcoma
significantly
involved
the
arachidonic
acid
(AA)
metabolic
pathway.
However,
role
of
metabolism-related
(AAMRGs)
prognosis
remains
unknown.
Methods
samples
from
The
Cancer
Genome
Atlas
(TCGA)
and
Gene
Expression
Omnibus
(GEO)
databases
were
classified
into
high-score
low-score
groups
based
on
AAMRGs
scores
obtained
through
ssGSEA
analysis.
intersecting
identified
weighted
gene
co-expression
network
analysis
(WGCNA),
DEGs
(osteosarcoma
vs.
normal)
DE-AAMRGs
(high-
low-score).
An
AA
metabolism
predictive
model
five
established
by
Cox
regression
LASSO
algorithm.
Model
performance
was
evaluated
using
Kaplan-Meier
survival
receiver
operating
characteristic
(ROC)
curve
In
vitro
experiments
related
biomarkers
validated.
Results
Our
study
constructed
an
prognostic
signature
(CD36,
CLDN11,
STOM,
EPYC,
PANX3).
K-M
indicated
patients
low-risk
group
showed
superior
overall
to
high-risk
(
p
<0.05).
ROC
curves
all
AUC
values
exceeded
0.76.
By
ESTIMATE
algorithms,
we
discovered
had
lower
immune
score,
stromal
estimate
score.
Correlation
strongest
positive
correlation
between
STOM
natural
killer
cells,
highest
negative
association
PANX3
central
memory
CD8
T
cells.
for
prognosis.
Conclusion
suggested
high
level
might
serve
as
biomarker
offers
potential
explanation
cyclooxygenase
inhibitors
cancer.
PANX3,
STOM)
screened
construct
risk
value,
providing
new
reference
treatment
osteosarcoma.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: June 27, 2024
Cuproptosis
is
a
novel
copper-dependent
programmed
cell
death.
The
efficacy
of
cuproptosis
highly
dependent
on
intracellular
copper
accumulation
and
counteracted
by
high
level
glutathione
(GSH)
in
tumor
cells.
Here,
this
work
develops
self-amplified
nanoparticles
(Cel-Cu
NP)
using
celastrol
(Cel),
natural
product
isolated
from
medical
plant.
In
Cel-Cu
NP,
Cel
serves
as
versatile
ionophore,
exhibiting
an
ideal
coordination
capacity
toward
ions
without
compromising
the
induction.
Notably,
can
simultaneously
scavenge
GSH
content
to
amplify
cuproptosis.
Moreover,
further
activates
immunogenic
death
(ICD)
elicit
robust
immune
response.
Combining
with
checkpoint
blockade,
NP
effectively
eradicates
metastatic
tumors
mouse
lung
metastasis
model.
This
study
provides
efficient
nanomedicine
inducing
for
immunotherapy.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: Jan. 25, 2024
Abstract
Cuproptosis,
an
emerging
form
of
programmed
cell
death,
has
received
tremendous
attention
in
cancer
therapy.
However,
the
efficacy
cuproptosis
remains
limited
by
poor
delivery
efficiency
copper
ion
carriers.
Herein,
complex
nanoparticles
(denoted
as
Cu(I)
NP)
are
developed
that
can
efficiently
deliver
into
cells
to
induce
cuproptosis.
NP
demonstrate
stimulus‐responsive
release
complexes,
which
results
mitochondrial
dysfunction
and
promotes
aggregation
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
leading
Notably,
not
only
cuproptosis,
but
also
elicit
robust
immune
responses
suppress
tumor
growth.
Overall,
this
study
provides
a
promising
strategy
for
cuproptosis‐based
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 8, 2024
Pyroptosis,
an
immunogenic
programmed
cell
death,
could
efficiently
activate
tumor
immunogenicity
and
reprogram
immunosuppressive
microenvironment
for
boosting
cancer
immunotherapy.
However,
the
overexpression
of
SLC7A11
promotes
glutathione
biosynthesis
maintaining
redox
balance
countering
pyroptosis.
Herein,
we
develop
intermetallics
modified
with
glucose
oxidase
(GOx)
soybean
phospholipid
(SP)
as
pyroptosis
promoters
(Pd
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 5, 2024
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 1, 2024
Abstract
The
in
vivo
fate
of
chemotherapeutic
drugs
plays
a
vital
role
understanding
the
therapeutic
outcome,
side
effects,
and
mechanism.
However,
lack
imaging
abilities
drugs,
tedious
labeling
processes,
premature
leakage
agents
result
loss
fidelity
between
signals.
Herein,
an
amphiphilic
polymer
is
created
by
copolymerization
near‐infrared‐II
(NIR‐II)
fluorophore
tracer
(T)
anticancer
Pt(IV)
prodrug
(D)
cisplatin
hand‐holding
manner
into
one
chain
for
first
time.
obtained
Polyplatin
DT
capable
delivering
fluorophores
concomitantly
at
precise
D/T
ratio,
thereby
resulting
tracking
platinum
even
readout
them
real‐time
via
NIR‐II
imaging.
can
self‐assemble
nanoparticles,
referred
to
as
Nanoplatin
.
Furthermore,
caspase‐3
cleavable
peptide
that
serves
apoptosis
reporter
attached
,
DTR
are
simultaneously
evaluating
efficacy.
Overall,
it
reported
here
design
theranostic
with
drug
tracers,
efficacy
reporters
work
concert
provide
insight
mechanism
action.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101446 - 101446
Published: Jan. 5, 2025
A
next-generation
STING
agonist
MSA-2
is
a
promising
tumor
immunotherapy
strategy.
However,
the
methods
for
improving
anti-tumor
efficacy
of
are
lot
effort.
We
have
demonstrated
antitumor
effect
platinum-modified
(MSA-2-Pt)
was
better
than
MSA-2.
Here,
we
combined
lipid
nanoparticles
delivering
circular
IL-23
mRNA
(LNP@cIL-23)
and
MSA-2-Pt
strategy,
which
showed
good
efficacy.
Firstly,
synthesized
new
series
ionizable
phospholipids
formulated
optimized
an
LNP36
mRNA.
Then,
combination
LNP36@cIL-23
induced
cell
death
immune
activation
in
with
single
i.t.
injection.
Finally,
significantly
decreased
melanoma
B16F10
prolonged
survival,
demonstrating
significant
effects.
This
finding
provides
avenues
strategies
immunotherapy.
Colorectal
cancer
continues
to
be
a
major
that
affects
patients
in
terms
of
morbidity
and
mortality.
Chemotherapy
using
cisplatin,
oxaliplatin
among
others
based
with
platinum
have
remained
the
mainstay
treatment
diverse
including
colorectal
cancer.
However,
these
treatments
are
not
very
effective
because
drug
resistance,
systemic
toxicity,
low
selectivity.
The
advances
nanotechnology
past
years
presented
nanoparticles
as
potential
delivery
systems
which
provide
sharp
targeting,
minimum
toxicity
better
therapeutic
efficacy.
This
review
aims
at
discussing
how
platinum-based
drugs
can
complement
nanoparticles,
for
example
liposomes,
dendrimers
gold
treatment.
review,
discussed
improve
effectiveness
drugs;
present
sample
findings
from
preclinical
clinical
research;
analyze
perspectives
such
combinations
current
therapy
shortcomings
overcoming.
Furthermore,
authors
looked
prospects
challenges
this
relatively
young
branch
research
discuss
opportunities
lie
personalized
medicine
concepts,
well
further
evolution
nanoparticles.
purpose
is
enhance
knowledge
platinum-nanoparticle
outline
its
future
directions
