Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 27, 2024

Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.

Language: Английский

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Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 25, 2024

Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based

Language: Английский

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Nanomedomics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

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A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR‐Light Triggered Hyperthermia

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 5, 2024

Abstract Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting high recurrence rates patients. Herein, a bioactive injectable hydrogel (BG‐Mn gel ) formed by crosslinking sodium alginate (SA) with manganese‐doped glass (BG‐Mn) is developed as versatile platform anti‐tumor immunotherapy postoperative The incorporation of Mn 2+ within (BG) can activate cGAS‐STING immune pathway to elicit robust response cancer immunotherapy. Furthermore, doping BG endows system excellent photothermal properties, hence facilitating STING activation reversing immune‐suppressive microenvironment. exhibits favorable angiogenic capacity tissue regenerative potential, promotes cell migration vitro. When combining BG‐Mn anti‐PD‐1 antibody (α‐PD‐1) melanoma, it shows enhanced long‐term memory response. Remarkably, upregulate expression genes related blood vessel formation promote skin regeneration when treating full‐thickness wounds. Overall, Gel serves an effective adjuvant therapy regulate

Language: Английский

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Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 470 - 485

Published: Feb. 2, 2024

Language: Английский

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Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd

Language: Английский

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Enhanced Antitumor Efficacy of STING Agonist MSA-2 by Lipid Nanoparticles Delivering Circular IL-23 mRNA and Platinum-Modified MSA-2 Combination

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101446 - 101446

Published: Jan. 5, 2025

A next-generation STING agonist MSA-2 is a promising tumor immunotherapy strategy. However, the methods for improving anti-tumor efficacy of are lot effort. We have demonstrated antitumor effect platinum-modified (MSA-2-Pt) was better than MSA-2. Here, we combined lipid nanoparticles delivering circular IL-23 mRNA (LNP@cIL-23) and MSA-2-Pt strategy, which showed good efficacy. Firstly, synthesized new series ionizable phospholipids formulated optimized an LNP36 mRNA. Then, combination LNP36@cIL-23 induced cell death immune activation in with single i.t. injection. Finally, significantly decreased melanoma B16F10 prolonged survival, demonstrating significant effects. This finding provides avenues strategies immunotherapy.

Language: Английский

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Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A Polyplatin with Hands‐Holding Near‐Infrared‐II Fluorophores and Prodrugs at a Precise Ratio for Tracking Drug Fate with Realtime Readout and Treatment Feedback

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 1, 2024

Abstract The in vivo fate of chemotherapeutic drugs plays a vital role understanding the therapeutic outcome, side effects, and mechanism. However, lack imaging abilities drugs, tedious labeling processes, premature leakage agents result loss fidelity between signals. Herein, an amphiphilic polymer is created by copolymerization near‐infrared‐II (NIR‐II) fluorophore tracer (T) anticancer Pt(IV) prodrug (D) cisplatin hand‐holding manner into one chain for first time. obtained Polyplatin DT capable delivering fluorophores concomitantly at precise D/T ratio, thereby resulting tracking platinum even readout them real‐time via NIR‐II imaging. can self‐assemble nanoparticles, referred to as Nanoplatin . Furthermore, caspase‐3 cleavable peptide that serves apoptosis reporter attached , DTR are simultaneously evaluating efficacy. Overall, it reported here design theranostic with drug tracers, efficacy reporters work concert provide insight mechanism action.

Language: Английский

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Silver incorporated SeTe nanoparticles with enhanced photothermal and photodynamic properties for synergistic effects on anti-bacterial activity and wound healing

RSC Advances, Journal Year: 2024, Volume and Issue: 14(27), P. 18871 - 18878

Published: Jan. 1, 2024

Synthesis of SeTe–Ag NPs with excellent photothermal and photodynamic properties for bacterial infection wound healing therapy.

Language: Английский

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