Advanced Biomaterials Derived from Functional Polyphosphoesters: Synthesis, Properties, and Biomedical Applications DOI
Jintao Li, Ying Hao, Hairong Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Polyphosphoesters (PPEs) represent an innovative class of biodegradable polymers, with the phosphate ester serving as core repeating unit their polymeric backbone. Recently, biomaterials derived from functionalized PPEs have garnered significant interest in biomedical applications because commendable biocompatibility, biodegradability, and capacity for functional modification. This review commences a brief overview synthesis methodologies distinctive properties PPEs, including thermoresponsiveness, degradability, stealth effect, biocompatibility. Subsequently, delves into latest PPEs-based nanocarriers drug or gene delivery prodrugs scaffolds field, presenting several illustrative examples each application. By encapsulating advancements recent years, this aims to offer enhanced understanding serve reference PPEs.

Language: Английский

Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy DOI
Sheng Lü, Yifan Li, Yingjie Yu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 27, 2024

Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.

Language: Английский

Citations

42
Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment DOI Creative Commons

Chaoxiong Wu,

Qingyu Yu,

Chenlu Huang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

Citations

18
Biodegradable Piezoelectric‐Conductive Integrated Hydrogel Scaffold for Repair of Osteochondral Defects DOI
Dingge Liu, Xinyu Wang, Chenyuan Gao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 13, 2024

Abstract Osteochondral injury is a prevalent condition for which no specific treatment currently available. This study presents piezoelectric‐conductive scaffold composed of piezoelectric cartilage‐decellularized extracellular matrix (dECM) and modified gelatin (Gel‐PC). The piezoelectricity the achieved through modification diphenylalanine (FF) assembly on pore surface, while conductive properties are by incorporating poly(3,4‐ethylenedioxythiophene). In vitro experiments demonstrate that bone marrow mesenchymal stem cells (BMSCs) undergo biphasic division during differentiation. vivo studies using Parma pig model osteochondral defects exhibits superior reparative efficacy. Notably, generation electrical stimulation linked to joint movement. During activity, mechanical forces compress scaffold, leading deformation subsequent an electric potential difference. positive charges accumulated upper layer attract BMSCs, promoting their migration chondrogenic Meanwhile, negative in lower induce osteogenic differentiation BMSCs. Overall, this piezoelectric‐conducive provides promising platform effective repair defects.

Language: Английский

Citations

14
NIR‐II Fluorescent Nanotheranostics with a Switchable Irradiation Mode for Immunogenic Sonodynamic Therapy DOI

Minhui Cui,

Dongsheng Tang, Hanchen Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Nanotheranostics, which integrate diagnostic and therapeutic functionalities, offer significant potential for tumor treatment. However, current nanotheranostic systems typically involve multiple molecules, each providing a singular or function, leading to challenges such as complex structural composition, poor targeting efficiency, lack of spatiotemporal control, dependence on single modality. This study introduces NP RBOXA , nanoparticle functionalized with surface‐bound cRGD targeted delivery α v β 3 /α 5 receptors cells, achieving theranostic integration by sequentially switching its irradiation modes. Under 808 nm laser irradiation, emits NIR‐II fluorescence, aids in identifying the nanoparticle's location fluorescence intensity, thereby determining optimal treatment window. Following this, mode switches ultrasound at Ultrasound induces generate reactive oxygen species, promoting reduction OXA‐IV OXA‐II, turn triggers immunogenic cell death. mechanism enables combination sonodynamic therapy, chemotherapy, immunotherapy The versatile design holds promise advancing precision oncology through enhanced efficacy real‐time imaging guidance.

Language: Английский

Citations

8
Activating the cGAS-STING Pathway by Manganese-Based Nanoparticles Combined with Platinum-Based Nanoparticles for Enhanced Ovarian Cancer Immunotherapy DOI

Xiangling Zhang,

Dongsheng Tang, Haihua Xiao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Recent research has demonstrated that activating the cGAS-STING pathway can enhance interferon production and activation of T cells. A manganese complex, called TPA-Mn, was developed in this context. The reactive oxygen species (ROS)-sensitive nanoparticles (NPMn) loaded with TPA-Mn are developed. NPMn activates via cGAS (i.e., 1.6-fold enhancement P-STING), which turn increases secretion pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-2). This promotes dendritic cell maturation, enhances infiltration cytotoxic lymphocytes, reduces percentage immunosuppressive regulatory In addition, it is crucial to emphasize cisplatin-induced DNA damage potentially trigger pathway. NPMn, combination low-dose NPPt, a carrier Cis(IV) prodrug capable causing damage, augments significantly tumor immune microenvironment (TIME). Furthermore, combined anti-PD-1 antibody, NPPt+NPMn shows synergistic efficacy both ovarian cancer peritoneal metastases recurrence models. It not only effectively eliminates tumors but also induces strong memory response, providing promising strategy for clinical management cancer. work offers design manganese-based immunotherapy.

Language: Английский

Citations

1
Sonodynamic Activated Nanoparticles with Glut1 Inhibitor and Cystine-containing Polymer Stimulate Disulfidptosis for Improved Immunotherapy in Bladder Cancer DOI Creative Commons
Ke Wang, Li Li,

Ganghao Liang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123178 - 123178

Published: Feb. 8, 2025

Language: Английский

Citations

1
Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy DOI Open Access

Minhui Cui,

Mengmeng Zhu, Dongsheng Tang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Language: Английский

Citations

1
Dual‐Gradient Silk‐Based Hydrogel for Spatially Targeted Delivery and Osteochondral Regeneration DOI Open Access
Yushu Wang, Xiao‐Yan Qin,

Yunhao Feng

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery reduced load‐bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical cues in native osteochondral tissues, a silk‐based hydrogel that facilitates spontaneous dual‐gradient formation, including mechanical growth factor gradients, tissue regeneration, is presented. Driven an electrical field, transitions from stiff to soft along anode‐to‐cathode direction, mimicking anisotropic structure natural tissues. Simultaneously, incorporated factors encapsulated charged monomers migrate cathode region, creating another parallel gradient enables sustained release. This design maintains bioactivity enhances programmable concentration defect environment. In rabbit model full‐thickness defects, demonstrates significant potential promoting offering promising tool translation.

Language: Английский

Citations

1
Facile One-Pot Synthesis of Ir(III) Bodipy Polymeric Gemini Nanoparticles for Tumor Selective NIR Photoactivated Anticancer Therapy DOI

Ganghao Liang,

Nicolás Montesdeoca, Dongsheng Tang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122618 - 122618

Published: May 21, 2024

Language: Английский

Citations

7
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment DOI
Yutang Li, Yandong Wang, Zhao Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

Citations

7