Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160576 - 160576
Published: Feb. 1, 2025
Language: Английский
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007
Published: April 29, 2024
Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.
Language: Английский
Citations
42
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 8, 2024
Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing development of dry eye disease (DED). The currently available drops DED treatment are palliative, short-lived and frequently administered due to short precorneal residence time. Here, we developed nanozyme-based exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) poly(vinyl alcohol) (PVA) overcome these problems. resultant formulation (PBnZ), which has dual-ROS scavenging abilities prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect alleviate DED. In vitro in vivo experiments revealed that PBnZ could eliminate ROS through both its multienzyme-like activity ROS-scavenging borate bonds. positively charged displayed longer time physical adhesion bonds phenyboronic acid PVA or o-diol with mucin. results showed These dual-function provide insights into novel strategies other ROS-mediated inflammatory diseases rationale application nanomaterials clinical settings. Graphical
Language: Английский
Citations
17
Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)
Published: July 3, 2024
Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe-LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) further modification on bioactive glass scaffold (BGS) obtain versatile platform (BGS@LDH/Se) for comprehensive osteosarcoma management. The uniform dispersion negatively charged SeNPs LDH surface restrains toxicity-inducing aggregation inactivation, thus enhancing superoxide dismutase (SOD) activation anion radical (·O
Language: Английский
Citations
17
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Language: Английский
Citations
16
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155383 - 155383
Published: Aug. 30, 2024
Language: Английский
Citations
15
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract Strategies of manipulating redox signaling molecules to inhibit or activate immune signals have revolutionized therapeutics involving reactive oxygen species (ROS). However, certain diseases with dual resistance barriers the attacks by both ROS and cells, such as bacterial biofilm infections medical implants, are difficult eradicate a single exogenous oxidative stimulus due diversity complexity involved. Here, this work demonstrates that metal‐organic framework (MOF) nanoparticles capable disrupting ROS‐defense system can dismantle induce potent antimicrobial responses in mouse model surgical implant infection simultaneously modulating homeostasis initiating neutrophil N1 polarization microenvironment. Mechanistically, piezoelectrically enhanced MOF triggers production tilting band structure acts synergistically aurintricarboxylic acid loaded within MOF, which inhibits activity cystathionine γ‐cleaving enzyme. This leads disruption antigen exposure through homeostatic imbalance synergistic activation signals. Thus, study provides an alternative but promising strategy for treatment antibiotic‐resistant infections.
Language: Английский
Citations
13
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 6, 2024
Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356) for synergistic SDT/immunotherapy. Specifically, a‐CoW‐LDH act as sonosensitizer generate abundant reactive oxygen species (ROS) under US irradiation. After loading a‐LDH@356 plus irradiation not only effectively induces ROS generation immunogenic death, but also inhibits elevation citrullinated histone H3 (H3cit) release NETs, enabling enhancement anti‐tumor metastasis effect. Using 4T1 model, it that combining YW3‐56 stimulates an by upregulating proportion immune‐activated cells inducing polarization M1 macrophages, escape downregulating expression PD‐1 on irradiation, which arrests primary progression inhibition rate 69.5% prevents least number lung nodules.
Language: Английский
Citations
10
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)
Published: May 28, 2024
Circularly polarized light (CPL) detection is of great significance in various applications such as drug identification, sensing and imaging. Atomically precise chiral metal nanoclusters with intense circular dichroism (CD) signals are promising candidates for CPL detection, which can further facilitate device miniaturization integration. Herein, we report the preparation a pair optically active silver [Ag
Language: Английский
Citations
10
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field
Language: Английский
Citations
2