International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7605 - 7616
Published: July 1, 2024
Corneal neovascularization (CNV) is a common eye disease that leads to blindness. New treatment strategies are urgently needed due the limitations of current methods.
Language: Английский
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Language: Английский
Citations
4
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)
Published: March 16, 2024
A low-generation lysine dendrimer, SPr-G2, responds to intracellular glutathione initiate bioorthogonal in situ polymerization, resulting the formation of large assemblies mouse breast cancer cells. The SPr-G2 can interact with lysosomes induce lysosome expansion and enhance lysosomal membrane permeabilization, leading major histocompatibility complex class I upregulation on tumor cell surfaces ultimately death. Moreover, use dendrimer conjugate chemotherapeutic drug, camptothecin (CPT), boost therapeutic potency CPT. Excellent antitumor effects vitro vivo are obtained from combinational treatment This effect also enhances immunity through promoting activation cytotoxic T cells tissues maturation dendritic study shed new light development peptide agents for therapy.
Language: Английский
Citations
8
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
The reprogramming of tumor metabolism presents a substantial challenge for effective immunotherapy, playing crucial role in developing an immunosuppressive microenvironment. In particular, the degradation amino acid L-tryptophan (Trp) to kynurenine (Kyn) by indoleamine-pyrrole 2,3-dioxygenase 1 (IDO1) is one most clinically validated pathways immune suppression. Thus, regulating Trp/Kyn IDO1 inhibition represents promising strategy enhancing immunotherapy. Herein, metabolism-regulated nanoparticles are prepared through metal coordination-driven assembly inhibitor (NLG919) and stimulator interferon genes (STING) agonist (MSA-2) enhanced After intravenous administration, assembled could efficiently accumulate tumors, bioavailability NLG919 down-regulating Trp Kyn remodel Meanwhile, released MSA-2 evoked potent STING pathway activation triggering response. antitumor immunity induced significantly inhibited development primary metastatic as well B16 melanoma. Overall, this study provided novel paradigm immunotherapy synergistic activation.
Language: Английский
Citations
8
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.
Language: Английский
Citations
1
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(12), P. 2993 - 3008
Published: Jan. 1, 2024
Peptides are a class of active substances composed variety amino acids with special physiological functions.
Language: Английский
Citations
5
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(19), P. 17243 - 17258
Published: Sept. 19, 2024
To effectively inhibit the growth and metastasis of non-small cell lung cancer (NSCLC) overcome its multidrug resistance (MDR), we designed synthesized a series rhodium (Rh, III) 2-benzoylpyridine thiosemicarbazone complexes. Through studying their structure-activity relationships, identified Rh(III) complex (Rh4) with excellent cytotoxicity against multidrug-resistant cells (A549/ADR cells). Additionally, successfully constructed an apoferritin (AFt) nanoparticle (NP) delivery system (AFt-Rh4 NPs). Importantly, AFt-Rh4 NPs not only exhibited antitumor antimetastatic capabilities NSCLC
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(29)
Published: May 1, 2024
Tumor cells harness Ca
Language: Английский
Citations
4
Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102471 - 102471
Published: Oct. 13, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1551 - 1551
Published: Feb. 12, 2025
Mitophagy plays a critical role in maintaining mitochondrial quality and cellular homeostasis. But the specific contribution of mitophagy-related E3 ubiquitin ligases to prognoses remains largely unexplored. In this study, we identified novel ligase prognostic signature using least absolute shrinkage selector operator (LASSO) multivariate Cox regression analyses breast cancer. Based on median risk scores, patients were divided into high-risk low-risk groups. Functional enrichment conducted explore biological differences between two Immune infiltration, drug sensitivity, mitochondrial-related phenotypes also analyzed evaluate clinical implications model. A four-gene (ARIH1, SIAH2, UBR5, WWP2) was identified, Kaplan-Meier analysis demonstrated that group had significantly worse overall survival (OS). The exhibited disrupted metabolism immune dysregulation with upregulated checkpoint molecules. Additionally, higher sensitivity several drugs targeting Akt/PI3K/mTORC1 signaling axis. Accompanying metabolic dysregulation, mtDNA stress elevated, contributing activation senescence-associated secretory phenotype (SASP) group. conclusion, provides robust tool for stratification offers insights interplay mitophagy, modulation, therapeutic responses
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161303 - 161303
Published: March 1, 2025
Language: Английский
Citations
0