Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158386 - 158386
Published: Dec. 9, 2024
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract Type 1 conventional dendritic cells (cDC1s) are key antigen‐presenting that efficiently activate CD8 + T cells, driving strong anti‐tumor immunity. cDC1s migration to the lymph node is a pivotal component. Previous studies often focused on enhancing (DCs) via CC chemokine receptor (CCR) 7 – ligand (CCL) 19/21 pathway, while simultaneously increasing tumor cell metastasis. In this study, new strategy provided accelerate DCs’ movement out of by reprograming their glutamine metabolism without causing metastasis cells. cDC1s‐targeting peptide‐modified liposomes used precisely deliver uptake SLC38A2 messenger RNA (mRNA) cDC1s, which increased need for and strengthens trophic gradient tendency toward nodes. addition, with overexpression showed higher levels maturation activation. vivo experiments demonstrate significant activation inhibition growth when systematic administration such nanomedicine in mouse models colorectal carcinoma. The results insight into regulating DCs behavior, especially migration,
Language: Английский
Citations
0
Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102691 - 102691
Published: Feb. 25, 2025
Citations
0
Nature Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Language: Английский
Citations
0
The Cancer Journal, Journal Year: 2025, Volume and Issue: 31(2)
Published: March 1, 2025
mRNA vaccines consist of antigen-encoding mRNA, which produces the antigenic protein upon translation. Coupling antigen production with innate immune activation can generate a potent, antigen-specific T-cell response. Clinical reports have demonstrated ability to elicit an anticancer response against various tumor types. Here, we discuss strategies enhance potency vaccines. We provide overview existing knowledge regarding and trafficking mechanisms share optimization boost mRNA-mediated production. In addition, address methods target dendritic cells lymph nodes, key initiators Finally, review for enhancing using adjuvants compatible offer unique advantages that be utilized oncology applications. However, significant work is needed understand their underlying develop technologies improve effectiveness.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113667 - 113667
Published: March 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Since the emergence of COVID-19 pandemic, mRNA vaccines have garnered significant attention. Delivery systems affect effectiveness vaccines, yet there remains a scarcity vectors that can achieve safe and efficient delivery mRNA. We took advantage self-assembled glycopeptides (SAPs) to develop vector named Man-MPm, which was coupled with mannose manganese ions lymph node targeting STING pathway activation. The Man-MPm-based vaccine exhibited high biosafety across various administration routes, eliciting robust antigen-specific immune responses within nodes. Due elevated antitumor immunity, Man-MPm significantly suppressed tumor growth extended survival period mice in melanoma prevention treatment models as well colon cancer model. Our findings show addresses challenges safety associated by incorporating node-targeting ligand agonist onto highly biocompatible SAP, holds great potential for developing vaccines.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Glioblastoma multiforme (GBM) is the most prevalent brain tumor that remains incurable up to now. The rapid advancement of immunotherapy makes vaccines a promising therapeutic approach for GBM. However, current vaccine platforms, such as peptides, dendritic cells, mRNA, and viral vectors, are subject limitations inadequate antigen loading, insufficient immune system activation, ineffective vector delivery, complicated fabrication process, complex formulation. Here, we developed GBM cell derived homologous exosomal nanovaccine does not need carry any additional antigens leads activation antigen-presenting cells (APCs) in lymph nodes, increasing proportion (matured cytotoxic T memory cells) turn promoting expression cytokines (TNF-α, IL-6, IFN-γ), which effectively stimulates innate immunity trigger durable protective against insult. Our platform possesses efficient dual-targeting capability nodes brain. More importantly, nanovaccines protected 100% treated mice by inducing sustained strong GL261-luc resulting mouse survival (8/8) 5 months. also induced antitumor responses immunosuppressed CT2A-luc model with greatly improved compared control mice. Exosomal demonstrated effectiveness preventing metastasis B16F10-luc melanoma malignant model, showed notably rates. simple potent exosomes offer versatile clinical translation individualized therapy.
Language: Английский
Citations
0
Journal of Liposome Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10
Published: July 15, 2024
Diabetic wound is one of the most challenge in healthcare, requiring innovative approaches to promote efficient healing. In recent years, lipid nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing diabetic repair by stimulating angiogenesis. These nanoparticles offer unique advantages, including improved stability, targeted delivery, and controlled release, making them formation new blood vessels. this review, we summarize emerging advances utilization deliver angiogenic agents angiogenesis wounds. Furthermore, provide an in-depth exploration key aspects, intricate design fabrication nanoparticles, their underlying mechanisms action, comprehensive overview preclinical studies. Moreover, address crucial considerations pertaining safety translation these into clinical practice. By synthesizing analyzing available knowledge, our review offers valuable insights future prospects challenges associated with utilizing potential promoting robust process
Language: Английский
Citations
2
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216165 - 216165
Published: Aug. 22, 2024
Language: Английский
Citations
2