International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125508 - 125508
Published: March 1, 2025
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(47)
Published: Aug. 16, 2024
Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.
Language: Английский
Citations
23
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.
Language: Английский
Citations
17
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 659 - 677
Published: Oct. 28, 2024
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Abstract The continuous exploration of new analogs calixarenes and pillararenes unlocks infinite opportunities in supramolecular chemistry materials. In this work, we introduce a class macrocycle, phenyl‐extended resorcin[4]arenes ( ExR4 ), unique innovative design that incorporates unsubstituted phenylene moieties into the resorcin[4]arene scaffold. Single‐crystal analysis reveals chair‐like conformation for per‐methylated Me‐ExR4 ) twisted “Figure‐of‐eight” shaped per‐hydroxylated OH‐ExR4 ). Notably, demonstrates exceptional adsorption capability toward I 3 − ions an aqueous solution, with rapid kinetic rate 1.18×10 −2 g ⋅ mg −1 min . Furthermore, shows excellent recyclability potential as stationary phase column setups. discovery opens up avenues constructing macrocycles inspires further research functional materials water pollutant removal.
Language: Английский
Citations
11
Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12
Published: March 18, 2024
Introduction: Cancer, a significant global health concern, necessitates innovative treatments. The pivotal role of chronic inflammation in cancer development underscores the urgency for novel therapeutic strategies. Benzothiazole derivatives exhibit promise due to their distinctive structures and broad spectrum biological effects. This study aims explore new anti-tumor small molecule drugs that simultaneously anti-inflammatory anticancer based on advantages benzothiazole frameworks. Methods: compounds were characterized by nuclear magnetic resonance (NMR), liquid chromatograph-mass spectrometer (LC-MS) high performance chromatography (HPLC) structure as well purity other related physicochemical properties. effects proliferation human epidermoid carcinoma cell line (A431) non-small lung lines (A549, H1299) evaluated MTT method. effect expression levels inflammatory factors IL-6 TNF-α mouse monocyte macrophages (RAW264.7) was assessed using enzyme-linked immunosorbent assay (ELISA). apoptosis cycle A431 A549 cells flow cytometry. migration scratch wound healing assay. protein Western Blot parameters, pharmacokinetic properties, toxicity drug similarity active compound predicted Swiss ADME admetSAR web servers. Results: Twenty-five designed synthesized, with confirmed through spectrogram verification. 6-chloro- N -(4-nitrobenzyl) benzo[d] thiazol-2-amine (compound B7 ) screened series bioactivity assessments, which significantly inhibited A431, H1299 cells, decreased activity TNF-α, hindered migration. In addition, at concentrations 1, 2, 4 μM, exhibited apoptosis-promoting cycle-arresting similar those lead 7-chloro- -(2, 6-dichlorophenyl) thiazole-2-amine 4i ). blot analysis both AKT ERK signaling pathways cells. prediction results ADMET indicated had good Discussion: has innovatively developed derivatives, focus its notable dual activities. stands out ability reduce A549, lower cytokines TNF-α. These position promising candidate dual-action therapy. study’s mechanistic exploration, highlighting ’s simultaneous inhibition pathways, offers strategy addressing survival mechanisms tumor milieu facilitating progression.
Language: Английский
Citations
10
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
In this review, we summarize five different types of pillar[5]arene-based nanomaterials and their applications in chemotherapy, photodynamic therapy, photothermal multimodal synergistic therapy for tumors.
Language: Английский
Citations
2
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 428, P. 137263 - 137263
Published: Jan. 15, 2025
Language: Английский
Citations
1
ChemMedChem, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the efficiency and reduce toxicity normal tissues through host‐guest interactions. Among them, pillar[n]arenes, as emerging class of macrocyclic compounds, have attracted increasing attention drug delivery drug‐controlled release due their high biocompatibility, excellent chemistry, simplicity modification. In this review, we summarize research progress pillar[n]arene‐based nanodrug systems (SNDs) recent years field tumor therapy, including release, imaging diagnostics therapeutic modalities. Furthermore, opportunities major limitations SNDs for therapy are discussed.
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 503 - 523
Published: Feb. 11, 2025
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 801 - 816
Published: Feb. 17, 2025
Language: Английский
Citations
1