Crosslink‐Enhanced Emission‐Dominated Design Strategy for Constructing Self‐Protective Carbonized Polymer Dots with Near‐Infrared Room‐Temperature Phosphorescence

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(44)

Published: Aug. 7, 2024

Abstract Self‐protective carbonized polymer dots (CPDs) with advantageous crosslinked nano‐structures have attracted considerable attention in metal‐free room temperature phosphorescence (RTP) materials, whereas their RTP emissions are still limited to short wavelength. Expanding Near‐Infrared (NIR) range is attractive but suffers from the difficulties constructing narrow energy levels and inhibiting intense non‐radiative decay. Herein, a crosslink‐enhanced emission (CEE)‐dominated construction strategy was proposed, achieving desired NIR (710 nm) self‐protective CPDs for first time. Structural factors, i.e., crosslinking (covalent‐bond CEE), conjugation (conjugated amine bridging N−H C=C group), steric hindrance (confined‐domain were confirmed indispensable triggering CPDs. Contrast experiments theoretical calculations further revealed rationality of design originating CEE terms promoting level triplet excitons quenching. This work not only firstly achieves also helps understand origin guide synthesis diverse efficient long‐wavelength emission.

Language: Английский

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Use of Quantum Dots as Nanotheranostic Agents: Emerging Applications in Rare Genetic Diseases

Small, Journal Year: 2025, Volume and Issue: 21(9)

Published: Jan. 19, 2025

Abstract Rare genetic diseases (RGDs) affect a small percentage of the global population but collectively have substantial impact due to their diverse manifestations. Although precise reasons behind these remain unclear, roughly 80% cases are genetically linked. Recent efforts focus on understanding pathology and developing new diagnostic therapeutic approaches for RGDs. However, there persists gap between fundamental research clinical approaches, where advancements in nanotechnology offer promising improvements. In this context, nanosized light‐emitting quantum dots (QDs), ranging from 2–10 nm, materials applications. Their size‐tunable light emission, high yield, photostability allow tracking cargo. Additionally, QDs can be functionalized with agents, antibodies, or peptides target specific cellular pathways, enhancing treatment efficacy while minimizing side effects. By combining capabilities single platform, thus versatile powerful approach tackle rare disorders. Despite several reviews various applications QDs, utilization domain RGDs is not well documented. This review highlight QDs’ potential diagnosing treating certain addresses challenges limiting application.

Language: Английский

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Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 291 - 339

Published: March 13, 2025

Language: Английский

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Revolutionary carbon quantum dots and their applications: A theoretical computations perspective

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113392 - 113392

Published: March 1, 2025

Language: Английский

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Scalable Synthesis of Self-Assembling Monodisperse Phosphorescent Nanospheres Enabling Multi-Mode Angle-Dependent and Thermal-Responsive Photonic Gels

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Developing room-temperature phosphorescent (RTP) materials with microscale periodic structures presents a promising prospect for future optical applications but remains extremely challenging due to the complex integration of luminescent and structural components. Herein, we present an emerging strategy mass-producing monodisperse RTP silica nanospheres (RTP SiO₂ NPs) using modified Stöber method, where organic molecules are embedded in networks undergone situ carbonization, aggregation crystallization form carbon dots under high temperature calcination. These NPs can self-assemble into photonic crystal (PC) structures, enabling straightforward color, fluorescence (FL) achieve multimodal properties. The angle-dependent bandgap (PBG) generated by physical structure modulates light propagation PC gel, creating unique FL chromatic responses. Temperature-induced refractive index changes between liquid matrix further enable dynamic control scattering states, significantly altering transmittance emission intensities RTP. This successful fusion chemical luminescence offers new approach constructing advanced devices.

Language: Английский

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Amino acid-like “Edge” and nanozyme “Core” structured CDs for overcoming cellular uptake barrier and enhancing tumor penetration

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 512, P. 162712 - 162712

Published: April 16, 2025

Language: Английский

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2D-network of boron-functionalized N-doped graphene quantum dots for electrochemical sensing of dopamine

Diamond and Related Materials, Journal Year: 2024, Volume and Issue: 146, P. 111259 - 111259

Published: June 1, 2024

Language: Английский

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Photocatalytic activities of graphene quantum dots constructed from four different nitropyrenes on water redox reaction and organic pollutant degradation

FlatChem, Journal Year: 2024, Volume and Issue: 47, P. 100735 - 100735

Published: Sept. 1, 2024

Language: Английский

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Phosphor doped carbon dots with high photoluminescence and stability towards pH and Cr(VI) sensors

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112046 - 112046

Published: Oct. 1, 2024

Language: Английский

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Modified Oxygen Metabolism Toward “Sunlight‐Friendly” Photodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Phototoxicity poses a substantial challenge in photodynamic therapy, resulting intolerable skin damage, visual impairment, and reduced quality of life. Current coping strategies, primarily focus on avoiding inappropriate photoactivation developing targeted photosensitizers, have not effectively addressed this problem. Hence, study aims to develop “sunlight‐friendly” therapy strategy. Here, 1‐methoxyphenazine methosulfate (MPMS) is innovatively identified as key substance achieving modified oxygen metabolism. MPMS demonstrates efficient catalytic shuttling under abnormal intracellular H 2 O levels, introducing novel protective approach for metabolism numerous life processes. By controlling administration, the switch photosensitizer states between “ON” (killing tumor cells) “OFF” (safeguarding normal can be achieved. This mitigated phototoxicity holds potential widespread clinical application.

Language: Английский

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