iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111602 - 111602
Published: Dec. 14, 2024
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763
Published: Aug. 17, 2024
Language: Английский
Citations
18
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 10, 2024
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) an innovative therapeutic approach that shows promise in elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer synthesized using Cu-doped carbon dots (Cu-CDs) sonodynamic treatment of GBM. Doping copper transforms into p-n type semiconductor having bandgap 1.58 eV, prolonged lifespan 10.7 µs, improved electron- hole-separation efficiency. The effect efficiency enhanced. Western blot analysis reveals Cu-CDs induces biological response leading to cell death, termed as cuproptosis. Specifically, upregulate dihydrosulfanyl transacetylase expression, thereby establishing synergistic against death when combined SDT. Furthermore, exhibit excellent permeability through blood-brain barrier potent anti-tumor activity. Importantly, effectively impede growth glioblastoma tumors prolong survival mice bearing these tumors. This study provides support application carbon-based nanomaterials therapy.
Language: Английский
Citations
15
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 12, 2024
Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cell-based vaccination is limited by interference from immunosuppressive senescence-associated secretory phenotype pro-tumorigenic capacity cells. Here, a nanovaccine strong immunogenicity favorable for immunotherapy reported. The biomimetic integrating cell membrane-coated nanoadjuvant outperforms living in enhancing dendritic (DCs) internalization, improving lymph node targeting, immune responses. In contrast nanovaccines generated death-induced tumor cells, facilitate DC maturation, eliciting superior protection therapeutic outcomes melanoma-challenged mice fewer side effects when combined αPD-1. study suggests versatile biomanufacturing approach maximize minimize adverse advances design immunotherapy.
Language: Английский
Citations
10
BMEMat, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Abstract Construction of drug carriers or prodrugs is a common approach to improve the pharmacokinetics molecular drugs and enhance tumor curative effect. Nanocarriers that can be activated by microenvironment including enzymes, pH, redox status, external stimuli such as ultraviolet, ultrasound, magnetism, are booming. As commonly used clinical theranostic with excellent spatiotemporal controllability deep tissue penetration, X‐ray has attracted much attention an stimulus in recent years. The rapid development nanomaterials radiosensitizers radioluminescents further accelerates construction X‐ray‐responsive nanocarriers. In this review, currently developed release systems cancer therapy summarized focus on controlled design.
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Abstract Despite the promise of activatable chemotherapy, development a spatiotemporally controllable strategy for prodrug activation in deep tissues remains challenging. Herein, proof‐of‐concept is proposed gold nanocluster‐based that utilizes X‐ray irradiation to trigger liberation platinum (Pt)‐based conjugates, thus enabling radiotherapy‐directed chemotherapy. Mechanistically, irradiated prodrugs achieved through direct photoelectron transfer from excited‐state nanoclusters Pt(IV) center, resulting release cytotoxic Pt(II) agents. Compared traditional combination chemotherapy and radiotherapy, this offers superior antitumor efficacy safety benefits spatiotemporal synergy at tumor site. Additionally, elicits robust immunogenic cell death yields profound outcomes combined immunotherapy breast cancer. This versatile ushering new era radiation‐mediated chemistry controlled drug delivery precise regulation biological processes.
Language: Английский
Citations
8
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114530 - 114530
Published: Jan. 20, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably undergoing spontaneous regeneration. Therefore, developed system named F10@MS@UV-HG integrated DUSP26-specific inhibitor into reactive oxygen species-responsive nanoparticles and embedded them photosensitive hydrogels. This effectively downregulated DUSP26 primary enhanced phosphorylation, ultimately promoting outgrowth. When transplanted mouse model, achieved sustained drug release, specifically targeting DUSP26/ERK/ELK1 pathway facilitating short-term Additionally, long-term repair effects─including improved myelination motor function─were evident mice F10@MS@UV-HG. The suggested activating signaling by modulating could promote functional recovery. Thus, exhibits enormous potential therapeutic approach for patients SCI.
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 136 - 136
Published: Jan. 30, 2025
(1) Background/Objectives: Primary and secondary brain tumours often hold devastating prognoses low survival rates despite the application of maximal neurosurgical resection, state-of-the-art radiotherapy chemotherapy. One limiting factor in their management is that several antineoplastic agents are unable to cross blood–brain barrier (BBB) reach tumour microenvironment. Nanomedicine could potential become an effective means drug delivery overcome previous hurdles towards neuro-oncological treatments. (2) Methods: A scoping review following PRISMA-ScR guidelines checklist was conducted using key terms input into PubMed find articles reflect emerging trends utilisation nanomedicine for primary tumours. (3) Results: The highlights various strategies by which different nanoparticles can be exploited bypass BBB; we provide a synthesis literature on ongoing contributions therapeutic protocols based chemotherapy, immunotherapy, focused ultrasound, radiotherapy/radiosurgery, radio-immunotherapy. (4) Conclusions: summarised this indicate encouraging advantageous properties as mechanisms; however, there still nanotoxicity issues largely remain addressed before translation these innovations from laboratory clinical practice.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which an inflammatory form programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting release various contents that intensify overall response within central nervous system. Therefore, targeting pyroptosis represents promising therapeutic strategy for treatment CIRI. Excessive generation reactive oxygen species (ROS) overactivated microglia considered to serve as signal molecule triggers NLRP3 inflammasome-mediated pyroptosis. However, current inhibitors solely focus on eliminating existing ROS or inhibiting inflammasome are not optimal. Here, coating nanothylakoids (NTs) coengineered with fibrin-binding peptide and MG1 onto dihydrotanshinone I (DT)-loaded nanocarriers, we have developed cascade-type inhibitor (MDN-MC) comprehensively regulates ROS/NLRP3/pyroptosis axis. The incorporation catalase surface MDN-MC, along DT, facilitated cascade inhibition scavenging suppressing expression NLRP3. In rat model transient middle artery occlusion, enhanced behavioral recovery neuronal repair were achieved through at lesion site implementation interventions inhibit pyroptosis, thereby demonstrating effects. Overall, this work emphasizes importance cascade-regulated reducing neuroinflammation, offering important mechanistic understanding possible approaches
Language: Английский
Citations
0