Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158388 - 158388
Published: Dec. 9, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment numerous cancer indications.
Language: Английский
Citations
10
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
The development of high-performing photocatalysts with visible-light-absorbing and oxidative properties for the degradation organic contaminants in anaerobic microenvironments remains a challenge. Herein, Ru-complex decorated coumarin ([Ru(phen)2Cur]Cl2) molecules was created to achieve high absorption capacities photocatalytic activity. Taking advantage nanoparticulate structure, transformation [Ru(phen)2Cur]Cl2 into Ru(II) nanostructures (RuCur NPs) not only exhibited an extensive broad visible-light spectrum but also possessed enhanced intersystem crossing efficiency improved electron transfer. Consequently, these self-assembled nanocatalysts performed efficient photodegradation toward both antibiotics dyes, especially acidic environments. Mechanistically, photoactivated electrons holes on surface drive via direct redox reactions oxygen-independent manner. This result proposed fundamental insight developing photocatalysts.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) laccase-like functionalities. The POD-like activity enables sensitive glucose detection human serum, the capability facilitates simultaneous degradation of phenolic pollutants wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging intrinsic catalytic properties. findings elucidate photo-regulation mechanisms nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable biosensing environmental remediation. work advances development adaptive nanomaterials programmable features biomedical ecological applications.
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
The engineering of metal nanoclusters (NCs) that exhibit bright emissions and high sensing performance under physiological conditions is still a formidable challenge. In this study, we report novel design strategy for realizing excellent NC-based probes by leveraging both concerted proton-coupled electron transfer (PCET) photoinduced (PET) mechanisms, with terbium(III) (Tb3+) ions serving as key modulator. Our findings indicate the binding Tb3+ to 6-aza-2-thiothymidine (ATT) ligand effectively inhibits proton-transfer step in PCET pathway Au10(ATT)6 NCs, giving rise over 10-fold enhancement fluorescence quantum yield 7.2%. Moreover, capped on surface NCs can act bridge facilitate an efficient donor-linker-acceptor type PET reaction from quercetin (Que) excited Au10 core specifically interacting bare 3-OH group. These advancements enable Tb3+/Au10(ATT)6 probe achieve significantly lower limit detection Que, reduced nearly 3 orders magnitude 2.6 nM, while also addressing critical difficulty selectively detecting Que presence its glycosylated analogues. This work opens new opportunities precise control photoluminescence NC at molecular level, potentially promoting development next-generation technologies.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122919 - 122919
Published: Oct. 25, 2024
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Abstract This study presents a nanohybrid that simultaneously improves both photothermal (PT) and photodynamic (PD) effects for cancer therapy. The conjugated polymer nanoparticle (CPN) comprises of p‐type as photosensitizer, charge donor, PT agent, n‐type acceptor PD Au nanoparticles (NPs) agent. is assembled through film dispersion process using hydrophobically modified phospholipid, producing high yield uniform hybrid NPs in short timeframe, displays exceptional effects, when activated at single near‐infrared wavelength. Photophysical analysis indicates the inclusion enhances nonradiative exciton relaxation, while incorporation boosts photoinduced transfer potentially contributes to charge‐recombination mediated triplet‐state formation an enhanced generation reactive oxygen species. During phototherapy, demonstrates most effective suppression primary tumor growth significantly anti‐tumor immune responses owing its simultaneous effects. Furthermore, combined with checkpoint inhibitors, treatment minimizes sizes maximizing survival rates mice. Thus, represents promising nanoplatform combination phototherapy treatment.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158388 - 158388
Published: Dec. 9, 2024
Language: Английский
Citations
0